Insights on Mechanisms of Cell Death in Cancer Cells

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: 10 July 2024 | Viewed by 2286

Special Issue Editor


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Guest Editor
Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
Interests: epigenetics; DNA methylation; transcriptional control; gene regulation; drug repurposing; neural stem cells; neurodevelopmental disorders; medulloblastoma brain tumor
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Special Issue Information

Dear Collogues,

The balance between cell survival and cell death are controlled through a cascade of cellular events that must be tightly regulated in a normal cell. The impaired regulation of such balance may cause human diseases that could extensively vary from degenerative diseases that are associated with increased cell death to cellular escape from cell death that may cause different types of human cancer. As such, aberrant cell death and deregulation of the correlated processes are commonly detected in cancer cells. In this Special Issue, we welcome review and original research papers that provide mechanistic insights into different types of cell death in cancer cells. This includes (but is not limited to) the cell-death-associated processes that occur in cancer cells; drug repurposing studies that affect cell survival and cell death in cancer cells; molecular mechanisms of programmed cell death such as apoptosis, as well as autophagy and necrosis; and studies that address tumor suppressor genes and oncogenes. All manuscripts that highlight regulatory mechanisms at different levels of transcription/translation, post-transcription/post-translation, cellular metabolism, and protein homeostasis using different, molecular, cellular, and multi-omics approaches are welcome for submission. 

Prof. Dr. Mojgan Rastegar
Guest Editor

Manuscript Submission Information

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Published Papers (1 paper)

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Review

16 pages, 1147 KiB  
Review
Apoptosis as a Barrier against CIN and Aneuploidy
by Johannes G. Weiss, Filip Gallob, Patricia Rieder and Andreas Villunger
Cancers 2023, 15(1), 30; https://doi.org/10.3390/cancers15010030 - 21 Dec 2022
Cited by 2 | Viewed by 2071
Abstract
Aneuploidy is the gain or loss of entire chromosomes, chromosome arms or fragments. Over 100 years ago, aneuploidy was described to be a feature of cancer and is now known to be present in 68–90% of malignancies. Aneuploidy promotes cancer growth, reduces therapy [...] Read more.
Aneuploidy is the gain or loss of entire chromosomes, chromosome arms or fragments. Over 100 years ago, aneuploidy was described to be a feature of cancer and is now known to be present in 68–90% of malignancies. Aneuploidy promotes cancer growth, reduces therapy response and frequently worsens prognosis. Chromosomal instability (CIN) is recognized as the main cause of aneuploidy. CIN itself is a dynamic but stochastic process consisting of different DNA content-altering events. These can include impaired replication fidelity and insufficient clearance of DNA damage as well as chromosomal mis-segregation, micronuclei formation, chromothripsis or cytokinesis failure. All these events can disembogue in segmental, structural and numerical chromosome alterations. While low levels of CIN can foster malignant disease, high levels frequently trigger cell death, which supports the “aneuploidy paradox” that refers to the intrinsically negative impact of a highly aberrant karyotype on cellular fitness. Here, we review how the cellular response to CIN and aneuploidy can drive the clearance of karyotypically unstable cells through the induction of apoptosis. Furthermore, we discuss the different modes of p53 activation triggered in response to mitotic perturbations that can potentially trigger CIN and/or aneuploidy. Full article
(This article belongs to the Special Issue Insights on Mechanisms of Cell Death in Cancer Cells)
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