Keratinocyte Carcinomas: Biology and Evolving Non-Invasive Management Paradigms
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 52151
Special Issue Editors
Interests: skin; photoprotection; skin cancer; inflammation; natural products; confocal microscopy
Special Issues, Collections and Topics in MDPI journals
Interests: dermatopathology, skin cancer; non-invasive diagnoses; confocal microscopy
Interests: photocarcinogenesis; non-melanoma skin cancer; photodynamic therapy; in vitro and in vivo models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Keratinocyte carcinomas (KCs) are the most prevalent form of cancer in the human population, and their rates are rising dramatically. Among the types of KCs, basal cell carcinoma (BCC) has the highest incidence, and squamous cell carcinoma (SCC) is less common, although it can metastasize, accounting for the majority of KC-related deaths. In the context of an aging population, we can expect an even greater burden on the healthcare system in the future. High-risk KCs that present on the face can cause morbidity and mortality and incur significant costs associated with treatment. Non-invasive diagnostic tools, such as dermoscopy, confocal microscopy, optical coherence tomography, and high-frequency ultrasound, have been introduced into clinical practice to facilitate better management of KCs. Non-surgical treatment options, such as photodynamic therapy (PDT) and topical imiquimod, have also been established, which have additional advantages providing both field treatment and optimal aesthetic results. However, a minority of KCs are resistant or recur after treatment, occasionally appearing more aggressive. In this sense, the possibility of combining therapies with different mechanisms of action may prove a better strategy to improve results and overcome current limitations. Furthermore, incorporating non-invasive diagnostic tools to confirm tumor clearance and monitor for recurrence may also be essential.
This Special Issue of Cancers is focused on KCs´ biology in addition to recent advances in non-invasive diagnosis, management, and treatment, with a special focus on PDT and imiquimod. The issue will include original articles on aspects related to the molecular mechanisms behind the development of these treatments. Translational work describing the value of these therapies, alone or in combination with other treatment modalities, will also be included, in addition to research focused on novel aspects of non-invasive diagnosis and monitoring.
Prof. Dr. Salvador GonzálezDr. Melissa Gill
Prof. Dr. Ángeles Juarranz
Guest Editors
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Keywords
- non-melanoma skin cancer
- non-invasive treatment
- PDT
- imiquimod
- non-invasive diagnoses
- RCM
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