Interconnectivity of Cell Death Pathways in Cancer

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5712

Special Issue Editor


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Guest Editor
Hormel Institute, Masonic Cancer Center, University of Minnesota, Austin, MN 55912-3679, USA
Interests: cell death; ovarian cancer; cancer stem cells; cell programmed necrosis (necroptosis); chemoresistance
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Special Issue Information

Dear Colleagues,

Programmed cell death research has encountered major developments over the last two decades. In the past, apoptosis was considered the only mechanistic pathway for regulated cell death, but recently various regulated cell death pathways (i.e., necroptosis, pyroptosis, ferroptosis) have emerged as playing a major role in both normal and pathological conditions. Today, we understand that many cell death pathways are interconnected and this fact may be critical to overcome bacterial resistance or chemoresistance.

This Special Issue plans to give an overview of the most recent advances in the field of programmed cell death and to bring into attention the interconnectivity of cell death pathways. This Special Issue is aimed at stressing the role of different cellular organelles in the cellular decision to succumb or survive upon receiving cell death signal.

Potential topics include, but are not limited to:

  • programmed cell death;
  • necroptosis;
  • apoptosis;
  • pyroptosis;
  • ferroptosis;
  • cell organelles and cell death;
  • reversibility of cell death

Dr. Ilana Chefetz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • programmed cell death
  • necroptosis
  • apoptosis, pyroptosis
  • ferroptosis
  • cell organelles and cell death
  • reversibility of cell death

Published Papers (1 paper)

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Review

13 pages, 1421 KiB  
Review
The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future
by Hung-Yu Lin, Hui-Wen Ho, Yen-Hsiang Chang, Chun-Jui Wei and Pei-Yi Chu
Cancers 2021, 13(18), 4576; https://doi.org/10.3390/cancers13184576 - 12 Sep 2021
Cited by 17 | Viewed by 4507
Abstract
Breast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid [...] Read more.
Breast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been implicated in the development and therapeutic responses of BC. Intriguingly, the induction of ferroptosis acts to suppress conventional therapy-resistant cells, and to potentiate the effects of immunotherapy. As such, pharmacological or genetic modulation targeting ferroptosis holds great potential for the treatment of drug-resistant cancers. In this review, we present a critical analysis of the current understanding of the molecular mechanisms and regulatory networks involved in ferroptosis, the potential physiological functions of ferroptosis in tumor suppression, its potential in therapeutic targeting, and explore recent advances in the development of therapeutic strategies for BC. Full article
(This article belongs to the Special Issue Interconnectivity of Cell Death Pathways in Cancer)
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