Dear Colleagues,

Key immune evasion mechanisms in established tumors have been well characterized, culminating with the clinical approval of several drugs targeting T cell immune checkpoints (ICP). By contrast, while the concept of tumor immune surveillance is well accepted, the very early events that permit immune sensing of pre-neoplastic cells remain poorly understood. The objective of this Special Issue is to gather original studies and reviews addressing immune sensing mechanisms of early cell transformation. The Special Issue is expected to assemble studies analyzing interactions between cells undergoing transformation and innate immune cells based on in vitro and/or in vivo models. Studies on conventional T/B cells are out of the scope of this Special Issue. Of specific interest are studies deciphering the role in the detection of early cell transformation of specific immune cell types, such as dendritic cells, macrophages, neutrophils, and other myeloid cells, and of innate lymphoid cells, including unconventional T cells (NKT, gdT cells) and NK cells. Further, studies deciphering tumor intrinsic molecular mechanisms (i.e., senescence, cellular stresses such as the UPR, Genomic stress) or intracellular sensors (Sting, RIG-I, etc.) leading to early immune alert are welcome.

Dr. Christophe Caux
Guest Editor

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• tumor immune surveillance
• Innate immune sensing
• dendritic cells
• myeloid cells
• innate lymphoid cells
• cellular stresses