Esophageal Squamous Cell Carcinoma

Dear colleagues, 

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive squamous cell carcinomas, requiring a multidisciplinary approach. Chemoradiotherapy has supplemented surgery as standard treatment of locally advanced ESCC. Local failure can be alternatively salvaged via photodynamic therapy. Cancer vaccines and immune checkpoint inhibitors are employed at present. Endoscopic resection is the preferred modality for early disease confined to the mucosa not involving the muscularis mucosa. Image-enhanced endoscopy with/without (ultra) magnification has merits for accurate predilection of ESCC invasion depth, substituting conventional iodine-staining or exceeding endoscopic ultrasound sonography. Artificial intelligence allows evolutions in the ESCC diagnostic field. State-of-art molecular–biologic technologies such as comprehensive genome-wide sequencing offer insights into the extent of genetic mutations in the epithelial tissue even from healthy esophagus, and how this relates to processes that drive ESCC development. The Special Issue will open doors to more recent advances gained from basic and clinical research.

Prof. Hajime Isomoto
Guest Editor

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