Epidermal Growth Factor Receptor (EGFR) Signaling in Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 7893
Special Issue Editors
Interests: EGFR transactivation; TGF-β signaling; gene regulation; tumor progression; fibroproliferative disease; EMT; skin cancer; cell motility; PAI-1
Special Issues, Collections and Topics in MDPI journals
Interests: Hippo signaling; renal fibrosis; kidney cancer; EGFR transactivation; Non-SMAD TGF-β pathway; tumor suppressor deregulation in fibrosis
Special Issues, Collections and Topics in MDPI journals
Interests: prostate cancer, cell migration and invasion; 3D cell models; tumor microenvironment; prostate carcinoma-associated fibroblasts; cell cycle, androgen receptor non-genomic actions; growth factor receptors; signal transduction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The epidermal growth factor receptor (EGFR) is a major contributor to tumor development and progression as well as an important therapeutic target. The EGFR and its ligands are often over-expressed in human carcinomas. Amplification of the EGFR gene, mutations within the EGFR tyrosine kinase domain and aberrant signaling are common in human epithelial malignancies where they impact tumor cell proliferation, plasticity, survival, localized tissue invasion and metastasis. The EGF/EGFR axis is also involved in drug resistance and pathologic cross-talk with other growth factor signaling pathways to promote inflammatory, angiogenic, fibrotic and mechanical changes in the tumor microenvironment, facilitating oncogenic behavior. EGFR transactivation by various cytokines and growth factors further underscore the complexity of engaged networks that dictate tumor cell phenotype and may shed light on the basis for the limited clinical utility of available EGFR inhibitors in halting cancer progression. The purpose of this Special Issue is to explore the expanding diversity of mechanisms that regulate EGFR activation and signaling in human neoplasms that may provide new opportunities for personalized anti-cancer therapy. We welcome submission of both review and original research articles for inclusion in this Special Issue by September 15, 2022
Dr. Paul J. Higgins
Dr. Rohan Samarakoon
Dr. Marzia Di Donato
Guest Editors
Manuscript Submission Information
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Keywords
- GFR in human cancer
- EGFR in tumor progression
- EGF/EGFR signaling
- EGFR mutations
- EGFR pathway cross talk
- EGFR transactivation
- EGFR inhibitors
- drug resistance
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