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Pharmaceuticals
Special Issues
Therapeutic Targets and Therapies in Graft versus Host Disease (GVHD)
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Therapeutic Targets and Therapies in Graft versus Host Disease (GVHD)

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 969

Special Issue Editors

Dr. Ioanna Sakellari

E-Mail Website
Guest Editor
George Papanicolaou General Hospital, Thessaloniki, Greece
Interests: hematopoietic cell transplantation; cellular therapy; gene therapy; CAR-T; allogeneic; autologous; graft-versus-host disease; toxicity
Special Issues, Collections and Topics in MDPI journals
Dr. Eleni Gavriilaki

E-Mail Website
Guest Editor
Second Propedeutic Department of Internal Medicine, Hippocration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
Interests: hematologic malignancies; thrombosis; complement; cellular therapy; lymphoma; myeloma; COVID-19
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hematopoietic cell transplantation remains the only curative approach for various malignant and non-malignant disorders. Over the past couple of decades, transplant modalities continue to evolve, expanding the donor and patient population and allowing for better the prevention and management of transplant complications. Nevertheless, acute and chronic graft-versus-host-disease (GVHD) remain major causes of morbidity and mortality in these patients. To this end, therapeutic targets and therapies are constantly expanding in GVHD, with potential benefits from additional combinations.

Our Special Issue “Therapeutic Targets and Therapies in Graft versus Host Disease (GVHD)” focuses on advances in understanding the current landscape in GVHD. This Special Issue welcomes basic, translational, and clinical research in the field, gathering both original research and review articles contributing to improving and understanding our knowledge in GVHD.

Dr. Ioanna Sakellari
Dr. Eleni Gavriilaki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • malignant disorders
  • hematopoietic cell transplantation
  • graft-versus-host disease (GVHD)
  • therapeutic targets
  • bone marrow transplant
  • stem cell transplant

Published Papers (1 paper)

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Review

15 pages, 824 KiB  
Review
Graft-Versus-Host Disease: Can Biomarkers Assist in Differential Diagnosis, Prognosis, and Therapeutic Strategy?
by Vaia-Aikaterini Alexoudi, Eleni Gavriilaki, Angeliki Cheva, Ioanna Sakellari, Stavroula Papadopoulou, Konstantinos Paraskevopoulos and Konstantinos Vahtsevanos
Pharmaceuticals 2024, 17(3), 298; https://doi.org/10.3390/ph17030298 - 26 Feb 2024
Viewed by 668
Abstract
A crucial complication after allogeneic hematopoietic cell transplantation (alloHCT), namely, acute graft-versus-host disease (aGVHD), occurs in about 50% of transplant recipients, leading to high morbidity and mortality. Thus far, the diagnosis of GVHD has been mainly established through clinical features and histologic or [...] Read more.
A crucial complication after allogeneic hematopoietic cell transplantation (alloHCT), namely, acute graft-versus-host disease (aGVHD), occurs in about 50% of transplant recipients, leading to high morbidity and mortality. Thus far, the diagnosis of GVHD has been mainly established through clinical features and histologic or laboratory evidence of periductal lymphocyte infiltration, fibroplasia, and mixed lymphocytic and plasmocytic inflammation. Intensive research is focused on identifying biomarkers for the early diagnosis, prediction of disease, response to treatment, prognosis, and risk stratification of patients. The serum biomolecules that have been investigated are reported and summarized. Moreover, oral tissue involvement in GVHD is described, and other biomarkers that have been proposed, such as saliva, are analyzed. Future research is highlighted as a necessity in order for these biomarkers to be validated and quantified for use in clinical practice. Full article
(This article belongs to the Special Issue Therapeutic Targets and Therapies in Graft versus Host Disease (GVHD))
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