Research Advances in Cancer Nanomedicine

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 2370

Special Issue Editor

Special Issue Information

Dear Colleagues,

Cancer is considered the evil of the Century, since it is the main cause of millions of deaths for the human species. Several issues related to heterogeneities of tumors, multidrug resistance and genetic factors are among major factors faced by (most of) targeted therapies and early diagnoses recently developed in cancer medicine. Cancer Nanomedicine, that is Nanotechnology applied to Cancer Theragnostic (e.g. Therapy plus Diagnosis) could shed a new starlight into the darkness of Neoplasia world. In this respect, several type of nanocarriers (“nanometric” entities like nanoparticles)-bringing reduced concentrations of antineoplastic drugs in their interior- can be driven to a target tumor by “Targeted Nano-Drug Delivery”, reducing unwanted side effects from therapeutic side, and on the other hand Lab-on-Chip Technologies have been also developed, being able to detect and quantify infinitesimal concentration of cancer biomarkers in order to enhance\speed up diagnosis, thus avoiding unpleasant biopsies. With this idea in mind, this Special issue is thought to bring together recent progresses and developments in the area of nanomedicine devoted to cancer therapy and diagnosis. For example, CAR-T Nano-technology and Nano-immunotherapy are among novel areas, attracting important financial resources and increasing interests in the stakeholders.

Prof. Dr. Stefano Leporatti
Guest Editor

Manuscript Submission Information

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Keywords

  • cancer
  • nanotechnology
  • nanomedicine
  • drug delivery
  • biosensors
  • lab-on-chip
  • nanomechanics
  • nano-immuno therapy
  • CAR-T nano-technology

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Published Papers (1 paper)

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Review

32 pages, 4970 KiB  
Review
Atomic Force Microscopy: A Versatile Tool in Cancer Research
by Francesca Persano, Alessandro Parodi, Tatiana Pallaeva, Ekaterina Kolesova, Andrey A. Zamyatnin, Jr., Vadim S. Pokrovsky, Valeria De Matteis, Stefano Leporatti and Mariafrancesca Cascione
Cancers 2025, 17(5), 858; https://doi.org/10.3390/cancers17050858 - 2 Mar 2025
Viewed by 1706
Abstract
The implementation of novel analytic methodologies in cancer and biomedical research has enabled the quantification of parameters that were previously disregarded only a few decades ago. A notable example of this paradigm shift is the widespread integration of atomic force microscopy (AFM) into [...] Read more.
The implementation of novel analytic methodologies in cancer and biomedical research has enabled the quantification of parameters that were previously disregarded only a few decades ago. A notable example of this paradigm shift is the widespread integration of atomic force microscopy (AFM) into biomedical laboratories, significantly advancing our understanding of cancer cell biology and treatment response. AFM allows for the meticulous monitoring of different parameters at the molecular and nanoscale levels, encompassing critical aspects such as cell morphology, roughness, adhesion, stiffness, and elasticity. These parameters can be systematically investigated in correlation with specific cell treatment, providing important insights into morpho-mechanical properties during normal and treated conditions. The resolution of this system holds the potential for its systematic adoption in clinics; its application could produce useful diagnostic information regarding the aggressiveness of cancer and the efficacy of treatment. This review endeavors to analyze the current literature, underscoring the pivotal role of AFM in biomedical research, especially in cancer cases, while also contemplating its prospective application in a clinical context. Full article
(This article belongs to the Special Issue Research Advances in Cancer Nanomedicine)
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