Clinical Pharmacology in Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 2697

Special Issue Editor


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Guest Editor
Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN 55905, USA
Interests: pharmacology of anti-cancer therapies; personalized medicine in cancer; colorectal cancer development, progression, and therapies; epigenetics and gene regulation; preclinical models; drug toxicity

Special Issue Information

Dear Colleagues,

Cancer therapeutic options are rapidly evolving and include the development of new advanced therapies that target vulnerabilities specific to cancer cells and the optimization of existing therapies to increase the efficacy and/or reduce occurrence of treatment-related adverse events. It is an exciting time for cancer pharmacology, with rapid advances improving treatment options for many cancer types at an unprecedented pace.

The purpose of this Special Issue is to highlight cutting-edge research in cancer pharmacology, including (1) the identification of new therapeutic targets in cancer and/or the development of new or refined targeted therapeutics, (2) improved methods for individualized anti-cancer therapies based on novel predictive biomarkers of the therapeutic response or toxicity, and (3) therapeutic resistance mechanisms and means to overcome resistance. Original research articles using preclinical or clinical models, as well as comprehensive reviews, are welcome for this Special Issue.

Dr. Steven Offer
Guest Editor

Manuscript Submission Information

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Keywords

  • pharmacology
  • personalized medicine
  • pharmacogenomics/pharmacogenetics
  • cancer
  • chemotherapy
  • targeted therapy
  • clinical trials
  • preclinical models
  • therapeutic toxicity
  • therapeutic efficacy
  • therapeutic resistance

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Published Papers (1 paper)

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Research

24 pages, 1312 KiB  
Article
Drug Interactions between Androgen Receptor Axis-Targeted Therapies and Antithrombotic Therapies in Prostate Cancer: Delphi Consensus
by Kori Leblanc, Scott J. Edwards, George Dranitsaris, Darryl P. Leong, Marc Carrier, Shawn Malone, Ricardo A. Rendon, Alison M. Bond, Troy D. Sitland, Pawel Zalewski, Michelle Wang and Urban Emmenegger
Cancers 2024, 16(19), 3336; https://doi.org/10.3390/cancers16193336 - 29 Sep 2024
Viewed by 2175
Abstract
Background/Objectives: Abiraterone acetate, apalutamide, darolutamide, and enzalutamide, which make up the androgen receptor axis-targeted therapies (ARATs) drug class, are commonly used in the management of prostate cancer. Many patients on ARATs also receive oral antithrombotic therapy (i.e., anticoagulants or antiplatelets). The concomitant [...] Read more.
Background/Objectives: Abiraterone acetate, apalutamide, darolutamide, and enzalutamide, which make up the androgen receptor axis-targeted therapies (ARATs) drug class, are commonly used in the management of prostate cancer. Many patients on ARATs also receive oral antithrombotic therapy (i.e., anticoagulants or antiplatelets). The concomitant use of ARATs and antithrombotic therapies creates the potential for clinically relevant drug–drug interactions, but the literature regarding the actual consequences of these interactions, and guidance for co-prescribing, is limited. We assembled a multidisciplinary panel of experts and provided them with clinical information derived from a comprehensive literature review regarding the drug–drug interactions between ARATs and antithrombotic therapies. Methods: A three-stage modified electronic Delphi process was used to gather and consolidate opinions from the panel. Each stage consisted of up to three rounds of voting to achieve consensus on which ARAT/antithrombotic therapy drug pairs warrant attention, the possible clinical consequences of drug–drug interactions, and suggested actions for management. Results: The panel achieved consensus to avoid 11 ARAT/antithrombotic therapy drug pairs and modify therapy for eight pairs. Assessments relied heavily on pharmacokinetic data and extrapolation from drug–drug interaction studies of similarly metabolized drugs. Conclusions: This e-Delphi process highlights the need for further research into the clinical impact of ARAT/antithrombotic drug interactions. Nonetheless, the suggested actions aim to provide clinicians with a practical framework for therapeutic decision making. Full article
(This article belongs to the Special Issue Clinical Pharmacology in Cancer)
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