Application of Artificial Intelligence in Breast Cancer Diagnosis, Prognosis, and Assessing Responses to Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: closed (15 February 2025) | Viewed by 3790

Special Issue Editors


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Guest Editor
Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal
Interests: machine learning; nuclear imaging; cancer

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Guest Editor
1. Coimbra Hospital and Universitary Centre, Gynecology Service, University of Coimbra, Coimbra, Portugal
2. Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra Institute for Clinical and Biomedical Research (iCBR), Coimbra, Portugal
Interests: clinical and translational research on gynecology

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Guest Editor
Champalimaud Foundation, Lisbon, Portugal
Interests: medical image processing; machine learning; brain imaging; cancer imaging

Special Issue Information

Dear Colleagues,

Breast cancer continues to present significant challenges due to its multifaceted nature, which is shaped by various factors such as clinical parameters, genetic predispositions, and environmental influences. Despite advancements in screening modalities and therapeutic interventions, early detection remains pivotal in enhancing patients’ prognoses. In this regard, the integration of genetic, histological, and imaging-based biomarkers into artificial intelligence (AI) models has shown great potential to enhance breast cancer diagnosis, patient stratification, predictions of responses to treatment, and assessments of early treatment response.

We are pleased to invite you to contribute to this Special Issue. We aim to delve into the intricate interplay between different AI models and biomarkers from diverse data sources.

This Special Issue has the following aims: 

  1. To shed light on the utility of AI algorithms in harnessing varied datasets—encompassing clinical records, genetic markers, and imaging biomarkers, among others—in order to refine risk prediction models for breast cancer. Such endeavors may facilitate initiatives with the ultimate goal of early detection.
  2. To explore the application of AI-driven analyses in deciphering the complexities of tumor microenvironments and molecular signatures, thereby enabling tailored treatment selection and prognostication of a given treatment’s efficacy.
  3. To address persistent challenges presented by factors like breast tissue density and false positives in screening programs; this will be achieved by exploring how AI methodologies can mitigate these challenges, thereby enhancing screening accuracy and resource optimization.
  4. To assess responses to therapy using AI as soon as possible, enabling faster and more effective personalization of treatment.

We encourage the submission of original research articles and reviews related to breast cancer to this Special Issue. Research areas may include (but are not limited to) the following:

  • Pioneering and validating novel AI algorithms for breast cancer risk assessment;
  • Harmonizing AI with multi-source data ecosystems;
  • Unveiling the enigmatic tumor microenvironment through AI-driven analyses;
  • Predicting responses to tailored therapies through AI;
  • Embracing the dawn of explainable AI (XAI) in breast cancer diagnosis;
  • Quantitative medical imaging and radiomics;
  • AI-based image enhancement technologies for breast cancer imaging.

We look forward to receiving your contributions.

Dr. Francisco Caramelo
Dr. Maria João Carvalho
Dr. Francisco P. M. Oliveira
Guest Editors

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Keywords

  • breast cancer
  • artificial intelligence
  • image processing
  • diagnosis
  • risk stratification
  • prognosis
  • treatment response assessment
  • personalized medicine
  • early detection

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Published Papers (1 paper)

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Review

28 pages, 1348 KiB  
Review
Harnessing Artificial Intelligence to Enhance Global Breast Cancer Care: A Scoping Review of Applications, Outcomes, and Challenges
by Jolene Li Ling Chia, George Shiyao He, Kee Yuen Ngiam, Mikael Hartman, Qin Xiang Ng and Serene Si Ning Goh
Cancers 2025, 17(2), 197; https://doi.org/10.3390/cancers17020197 - 9 Jan 2025
Cited by 1 | Viewed by 3185
Abstract
Background: In recent years, Artificial Intelligence (AI) has shown transformative potential in advancing breast cancer care globally. This scoping review seeks to provide a comprehensive overview of AI applications in breast cancer care, examining how they could reshape diagnosis, treatment, and management on [...] Read more.
Background: In recent years, Artificial Intelligence (AI) has shown transformative potential in advancing breast cancer care globally. This scoping review seeks to provide a comprehensive overview of AI applications in breast cancer care, examining how they could reshape diagnosis, treatment, and management on a worldwide scale and discussing both the benefits and challenges associated with their adoption. Methods: In accordance with PRISMA-ScR and ensuing guidelines on scoping reviews, PubMed, Web of Science, Cochrane Library, and Embase were systematically searched from inception to end of May 2024. Keywords included “Artificial Intelligence” and “Breast Cancer”. Original studies were included based on their focus on AI applications in breast cancer care and narrative synthesis was employed for data extraction and interpretation, with the findings organized into coherent themes. Results: Finally, 84 articles were included. The majority were conducted in developed countries (n = 54). The majority of publications were in the last 10 years (n = 83). The six main themes for AI applications were AI for breast cancer screening (n = 32), AI for image detection of nodal status (n = 7), AI-assisted histopathology (n = 8), AI in assessing post-neoadjuvant chemotherapy (NACT) response (n = 23), AI in breast cancer margin assessment (n = 5), and AI as a clinical decision support tool (n = 9). AI has been used as clinical decision support tools to augment treatment decisions for breast cancer and in multidisciplinary tumor board settings. Overall, AI applications demonstrated improved accuracy and efficiency; however, most articles did not report patient-centric clinical outcomes. Conclusions: AI applications in breast cancer care show promise in enhancing diagnostic accuracy and treatment planning. However, persistent challenges in AI adoption, such as data quality, algorithm transparency, and resource disparities, must be addressed to advance the field. Full article
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