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Clinical and Translational Research in Head and Neck Cancer—2nd Edition

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 25 June 2026 | Viewed by 956

Special Issue Editor


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Guest Editor
Chair Oncology, Global Development Scientific Council, Regeneron Pharmaceuticals, New York, NY, USA
Interests: cancer immunology; tumor microenvironment; immune oncology

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of a previous Special Issue entitled “Clinical and Translational Research in Head and Neck Cancer”.

Head and neck cancer encompasses multiple histologic tumors that can represent the breadth of most human cancers, and these cancers’ unique occurrences in the face/scalp and the upper digestive tracts, including the sinonasal tracts, oral cavity, oropharynx, larynx, and cervical esophagus, provide unique challenges for scientists and clinicians. Although there are now new approved drugs for many of these tumor types, there are still important clinical concerns for weighing up oncologic cures and functional preservation. Hence, the incorporation of new modalities, such as immunotherapy and targeted biologics, will require basic, clinical, and translational research for optimal patient care that incorporates locoregional recurrence, overall survival, and quality of life maintenance. This Special Issue presents some of these recent advances in oncologic therapeutics in head and neck cancer patients to promote future translational and clinical studies.

Dr. Young J. Kim
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck cancer
  • immunotherapy
  • translation
  • combinatorial clinical trials
  • oncologic therapeutics

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Published Papers (1 paper)

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Research

13 pages, 554 KB  
Article
Post-Radiation PET Shows Higher Diagnostic Accuracy in HPV-Negative Head and Neck Cancers
by Kornél Dános, Angéla Horváth, Emese Kristóf, Imre Uri, Benedek Besenczi, Peter Prekopp, László Tamás, Gábor Polony and Tamás Györke
Cancers 2026, 18(8), 1237; https://doi.org/10.3390/cancers18081237 - 14 Apr 2026
Viewed by 661
Abstract
Background: Post-treatment evaluation of residual neck disease in head and neck squamous cell carcinoma (HNSCC) is challenging because of treatment-related changes and biological differences between HPV-positive and HPV-negative tumors. Methods: We performed a prospective single-center study of 58 node-positive HNSCC patients treated with [...] Read more.
Background: Post-treatment evaluation of residual neck disease in head and neck squamous cell carcinoma (HNSCC) is challenging because of treatment-related changes and biological differences between HPV-positive and HPV-negative tumors. Methods: We performed a prospective single-center study of 58 node-positive HNSCC patients treated with definitive chemoradiotherapy (CRT) followed by 18F-FDG PET/CT. PET-positive patients underwent neck dissection, while PET-negative patients were followed clinically for at least two years. Diagnostic performance was analyzed by p16 status. Results: PET/CT showed high overall accuracy (sensitivity 94%, specificity 83%, PPV 70%, NPV 97%). In p16-negative cases, sensitivity was 93%, specificity 80%, PPV 81%, and NPV 92%. In p16-positive cases, sensitivity and NPV reached 100%, but PPV was only 43%, indicating frequent false positives. Residual disease requiring neck dissection was associated with significantly worse survival (p = 0.008). Conclusions: PET/CT is reliable for post-treatment assessment, especially in p16-negative HNSCC. In p16-positive cases, careful interpretation and standardized PET/CT criteria are needed to reduce false positives and avoid unnecessary surgery. Full article
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