Advances in Brain Circuits and Sensory Information: Chronic Visceral Pain
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Systems Neuroscience".
Deadline for manuscript submissions: closed (16 June 2022) | Viewed by 4753
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chronic pain involving internal viscera is a significant and complex problem worldwide. Chronic visceral pain is mediated by hypersensitivity occurring within sensory pathways as a consequence of pathologies occurring in the brain–gut axis, such as those related to stress and those related to peripheral sensitisation related to dietary or bacterial inflammation. Regardless of the origin, altered signalling within the spinal cord and brain is a key factor in facilitating the chronicity of visceral pain. Central changes also facilitate cross-organ sensitization that underlies debilitating pain and autonomic co-morbidities that are often associated with chronic visceral pain syndromes that are difficult to manage clinically.
The Special Issue aims to gather contemporary findings on molecular mechanisms and circuit disruptions occurring within the spinal cord and brain, at a cellular and systems level, involved in chronic visceral pain. The issue will bring together reviews and original research articles on peripheral and central pathology affecting visceral pain signalling within brain circuits in humans and in models of chronic visceral pain, their role in facilitating visceral cross-sensitisation and autonomic dysfunction, and mechanisms that pose as potential therapeutic strategies.
Dr. Andrea Harrington
Guest Editor
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Keywords
- chronic visceral pain
- spinal cord
- neuropharmacology
- cross-organ sensitization
- brain–gut axis
- central sensitization
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