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Brain Sciences
Special Issues
Non-invasive Neuromodulation for Brain Function: Past, Present and Promise
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Non-invasive Neuromodulation for Brain Function: Past, Present and Promise

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotechnology and Neuroimaging".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 1779

Special Issue Editor

Dr. Jiajia Yang

E-Mail Website
Guest Editor
1. School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300372, China
2. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300372, China
Interests: neurological disorders; dementia; depression; neuromodulation; neuroplasticity

Special Issue Information

Dear Colleagues,

Neuromodulation is an expanding technique integrating medicine, biology and engineering, including non-invasive and invasive methods. Among them, the former has the advantage of being efficient and safe and is applied in neuropsychiatry therapy. Non-invasive neuromodulation can regulate the neural activity of the brain to affect brain functions including cognition, emotion, social behavior, and so on. The main intervention types include transcranial electrical stimulation, transcranial magnetic stimulation, transcranial ultrasound stimulation, etc. Over the past twenty years, non-invasive neuromodulation has played an increasingly important role in the treatment of many neuropsychiatric diseases, such as depression, Parkinson's disease, Alzheimer's disease, schizophrenia and vascular dementia.

This Special Issue entitled Non-invasive Neuromodulation for Brain Function: Past, Present and Promise aims to present a collection of studies detailing the most recent advancements in the field of non-invasive neuromodulation for brain function. We welcome original research papers, theoretical and methodology papers, and review papers describing the generation, use, and knowledge translation of non-invasive neuromodulation.

Dr. Jiajia Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Review

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14 pages, 784 KiB  
Review
Advances in Non-Invasive Neuromodulation Techniques for Improving Cognitive Function: A Review
by Ruijuan Chen, Lengjie Huang, Rui Wang, Jieying Fei, Huiquan Wang and Jinhai Wang
Brain Sci. 2024, 14(4), 354; https://doi.org/10.3390/brainsci14040354 - 1 Apr 2024
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Abstract
Non-invasive neuromodulation techniques are widely utilized to study and improve cognitive function, with the aim of modulating different cognitive processes. For workers performing high-intensity mental and physical tasks, extreme fatigue may not only affect their working efficiency but may also lead to cognitive [...] Read more.
Non-invasive neuromodulation techniques are widely utilized to study and improve cognitive function, with the aim of modulating different cognitive processes. For workers performing high-intensity mental and physical tasks, extreme fatigue may not only affect their working efficiency but may also lead to cognitive decline or cognitive impairment, which, in turn, poses a serious threat to their physical health. The use of non-invasive neuromodulation techniques has important research value for improving and enhancing cognitive function. In this paper, we review the research status, existing problems, and future prospects of transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial magnetic stimulation (TMS), and transcutaneous acupoint stimulation (TAS), which are the most studied physical methods in non-invasive neuromodulation techniques to improve and enhance cognition. The findings presented in this paper will be of great reference value for the in-depth study of non-invasive neuromodulation techniques in the field of cognition. Full article
(This article belongs to the Special Issue Non-invasive Neuromodulation for Brain Function: Past, Present and Promise)
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8 pages, 1214 KiB  
Brief Report
Neuronavigated Right Orbitofrontal 20 Hz Theta Burst Transcranial Magnetic Stimulation Augmentation for Obsessive–Compulsive Disorder with Comorbid Depression and Anxiety Disorders: An Open-Label Study
by William F. Stubbeman, Jennifer Yang, Julianne Converse, Melodi Gencosmanoglu, Daisy Morales Ortega, Jordyn Morris, Andrew Sobocinski, Vicky Li, Gabriella Gunawardane, Yana Edelen, Raya Khairkhah and Jillian Perez
Brain Sci. 2024, 14(5), 483; https://doi.org/10.3390/brainsci14050483 - 10 May 2024
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Abstract
Background: Despite the availability of pharmacotherapy and psychotherapy for treating obsessive–compulsive disorder (OCD), alternative approaches need to be explored due to the high likelihood of treatment resistance. Neuronavigated 20 Hz theta burst stimulation (TBS-20 Hz), targeting the bilateral dorsolateral prefrontal cortex (DLPFC) augmented [...] Read more.
Background: Despite the availability of pharmacotherapy and psychotherapy for treating obsessive–compulsive disorder (OCD), alternative approaches need to be explored due to the high likelihood of treatment resistance. Neuronavigated 20 Hz theta burst stimulation (TBS-20 Hz), targeting the bilateral dorsolateral prefrontal cortex (DLPFC) augmented with the right orbitofrontal cortex (ROFC), was tested for treating OCD comorbid with depression and anxiety disorders. Methods: A retrospective chart review was performed on fourteen patients treated for moderate-to-severe OCD in a private outpatient clinic. Twelve patients had comorbid major depressive disorder (MDD), and thirteen patients had either generalized anxiety disorder (GAD) or panic disorder (PD). Patients completed the Y-BOCS-SR, BDI-II, and BAI rating scales weekly, which were used to measure the changes in OCD, depression, and anxiety symptoms, respectively. Results: Neuronavigated TBS-20 Hz was sequentially applied to the right DLPFC (RDLPFC), left DLPFC (LDLPFC), and ROFC. A total of 64% (9/14) of patients achieved remission from OCD (Y-BOCS-SR ≤ 14) in an average of 6.1 weeks of treatment (SD = 4.0). A total of 58% (7/12) of patients remitted from MDD (BDI < 13) in an average of 4.1 weeks (SD = 2.8), and 62% (8/13) of patients remitted from GAD/PD (BAI < 8) in an average of 4.3 weeks (SD = 2.5). Conclusions: The neuronavigated TBS-20 Hz sequential stimulation of RDLPFC and LDLPFC, followed by ROFC, significantly reduced OCD, MDD, and GAD/PD symptoms. Randomized sham controls are warranted to validate these results. Full article
(This article belongs to the Special Issue Non-invasive Neuromodulation for Brain Function: Past, Present and Promise)
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