Special Issue "HIV-Associated Neurocognitive Disorders (HAND)"
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (28 February 2017).
Interests: HIV; cognitive impairment; HIV and aging
Special Issues and Collections in MDPI journals
Effective combination antiretroviral therapy (cART) has lead to a significant reduction in the prevalence and incidence of central nervous system (CNS) HIV-associated brain disease, particularly, CNS opportunistic infections and HIV encephalitis. Despite this, cognitive deficits in people living with HIV (PLWH) have become more apparent in recent years. The term HAND (HIV associated neurocognitive impairment) has been defined as cognitive impairment associated exclusively with HIV infection. However, defining if cognitive disorders in PLWH are due to HAND or other causes can be cumbersome on an individual basis. Several clinical risk factors that contribute towards cognitive impairment in PLWH, but are not specific to HIV infection per se, have been suggested, and include ageing, greater use of recreational drugs, increase rates of depression and anxiety, and high prevalence other comorbidities (cerebrovascular disease), and co-infections (hepatitis C and syphilis) that are known to affect the CNS. The development of HAND has been associated with antiretroviral therapy (poor drug concentration vs. neurotoxicity) and low-level CNS HIV replication, but more recently the role of brain immuneactivation in the development of HAND is taking central stage and could pave the wave for the development of new anti-inflammatory therapeutics for the management of HAND. As a result of a combination of successful viral control and enhanced survival with modern antiretroviral therapies, the global HIV-positive cohort is aging. There are concerns that an aging HIV population will be more prone to develop HAND, and therefore, novel strategies to treat and identify those individuals that are at most risk to develop HAND are urgently needed.
This Special Issue aims to describe factors associated with the development of HAND and other cognitive deficits affecting PLWH on effective cART, as well as describing novel strategies for the management of PLWH with cognitive difficulties.
Dr. Jaime Vera Rojas
Manuscript Submission Information
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