Neural Circuits for Pain Modulation

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Sensory and Motor Neuroscience".

Deadline for manuscript submissions: closed (1 November 2024) | Viewed by 2758

Special Issue Editor

Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX 75246, USA
Interests: neurobiology of pain; chronic pain; orofacial pain; neuropathic pain; inflammatory pain; oral cancer pain; opioid-induced hyperalgesia
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Special Issue Information

Dear Colleagues,

In recent years, an increasing amount of evidence has demonstrated that neural circuit mechanisms are critical for modulating different types of pain. Meanwhile, some cutting-edge techniques, such as optogenetic stimulation, chemogenetic manipulation, and in vivo calcium imaging, have been developed to unravel pain-related neural circuits in the central nervous system. In this Special Issue, we will solicit papers on basic, translational, and clinical pain research, focusing on dissecting the brain or spinal cord neural circuits that underlie pain modulation in different pain conditions.

The manuscripts can include, but are not limited to, the following:

  • Central mechanisms and neural circuits for chronic pain;
  • The single-cell sequencing analysis of pain-related neural circuits;
  • The multi-channel recording of real-time neuronal activity in freely behaving animals with chronic pain;
  • The simultaneous monitoring of presynaptic neurotransmitter release and postsynaptic neuronal activity in pain-related neural circuits, while measuring pain;
  • Neural circuits-targeted neuromodulation therapy for refractory pain.

Dr. Feng Tao
Guest Editor

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Keywords

  • chronic pain
  • neural circuits
  • neuromodulation
  • optogenetics
  • chemogenetics
  • multi-channel recording
  • miniature microscopy

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Published Papers (1 paper)

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Review

18 pages, 1133 KiB  
Review
Mechanisms Underlying Sex Differences in Temporomandibular Disorders and Their Comorbidity with Migraine
by Adnan Khan, Sufang Liu and Feng Tao
Brain Sci. 2024, 14(7), 707; https://doi.org/10.3390/brainsci14070707 - 15 Jul 2024
Cited by 4 | Viewed by 2439
Abstract
Sexual dimorphism in temporomandibular disorders (TMDs) and their comorbidity with migraine are important phenomena observed in clinics. TMDs are the most prevalent orofacial pain conditions with jaw joint and masseter muscle dysfunction. Migraine is the predominant headache commonly associated with TMDs. Women much [...] Read more.
Sexual dimorphism in temporomandibular disorders (TMDs) and their comorbidity with migraine are important phenomena observed in clinics. TMDs are the most prevalent orofacial pain conditions with jaw joint and masseter muscle dysfunction. Migraine is the predominant headache commonly associated with TMDs. Women much more often suffer from this orofacial pain than men. However, currently, there is no gender-specific therapy for such pain conditions. Understanding the pathophysiological mechanisms behind sex differences in TMDs as well as their comorbidity with migraines is essential for developing novel approaches for gender-specific treatment of TMDs and related orofacial pain comorbidity. In this review, we summarize recent research progress regarding sex differences in TMDs, focusing on the underlying mechanisms including craniofacial anatomy, hormonal regulation, and roles of opioids, transient receptor potential channels, and endocannabinoid systems. We also discuss the mechanisms of comorbid TMDs and migraine. The information covered in this review will provide mechanistic insights into sex differences in TMDs and their comorbidity with migraine, which could aid in developing effective treatment strategies for the overlapping orofacial pain condition. Full article
(This article belongs to the Special Issue Neural Circuits for Pain Modulation)
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