Functions and Mechanisms of Protective Biomolecules in Metabolic Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 20 July 2026 | Viewed by 1333
Special Issue Editors
Interests: trefoil family peptides (Tffs); gut-liver-brain axis; animal model of Tff3 deficiency; metabolism
Special Issues, Collections and Topics in MDPI journals
Interests: mass spectrometry; proteomics; metabolomics; omics data integration; metabolism
Special Issues, Collections and Topics in MDPI journals
Interests: chemotherapy; chemoresistance; cancer biology; colon cancer; cell signaling; proteomics; lipidomics; sphingolipids; biomarkers; personalised medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic diseases pose a major and escalating burden on global public health. Besides diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis, recent data underline cancer as a metabolic mitochondrial disease, urging a reconsideration of treatment options.
Systemic metabolic homeostasis begins with proper nourishment and function of the gastrointestinal tract (GI). Dysregulation of GI function leads to a vicious cycle of disruptions in cellular and systemic metabolic homeostasis, resulting in severe complications and increased morbidity.
In recent years, research has increasingly focused on the role of endogenous protective biomolecules—including adipokines, hepatokines, myokines, and various bioactive lipids and peptides—that can counteract metabolic stress, inflammation, and cellular damage.
Understanding the precise functions and underlying mechanisms of these molecules, such as their involvement in insulin sensitisation, lipid metabolism, and mitochondrial function, opens promising avenues for therapeutic intervention.
This Special Issue invites original research articles, reviews, and perspectives that explore the identification, regulation, and mechanistic actions of protective biomolecules in different metabolic diseases. Contributions highlighting novel signalling pathways, their roles in inter-organ communication, or translational potential as biomarkers or therapeutic targets are particularly encouraged.
Dr. Mirela Baus Lončar
Dr. Anita Horvatić
Dr. Mirela Sedić
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protective biomolecules
- metabolic homeostasis
- insulin resistance
- cancer metabolism
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