Special Issue "New Insights on Translational Machinery in Protein Synthesis and Beyond"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules".

Deadline for manuscript submissions: 15 March 2020.

Special Issue Editor

Dr. Byung Woo Han
E-Mail Website
Guest Editor
College of Pharmacy, Seoul National University, Seoul, Korea
Interests: Translational machinery in health and disease; Non-translational functions of translational machinery; Aminoacyl-tRNA synthetase biology; Structural Biology

Special Issue Information

Dear Colleagues,

Translation machinery is vital for all living organisms. Basically, translation machinery is composed of mRNA, tRNA, aminoacyl-tRNA synthetase, ribosomes, and their related components for biosynthesis and processing. Although prokaryotic and eukaryotic translation machinery shares fundamental mechanisms for protein biosynthesis, the detailed modes of action for each aspect of the translation machinery are quite diverse, which provides niches to characterize their identities and to discriminate one from another. This characteristic allowed for the development of antibiotics. In addition, eukaryotic translation machinery often contains domains not only for translational purposes but for additional/auxiliary/non-translational functions with unexpected physiological effects. In particular, aminoacyl-tRNA synthetases have been well known to play crucial roles in diverse cellular processes, such as cancer development, the immune system, and metabolism. For this Special Issue we are calling for research articles focusing on new insights of translation machinery in protein biosynthesis and beyond. This topic includes but is not limited to mRNA processing, tRNA processing, aminoacyl-tRNA synthetase, and ribosome biology.

Dr. Byung Woo Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Translation machinery in health and disease
  • Non-translational functions of translational machinery
  • Structure determination of translation machinery components
  • Complex structure determination of translation machinery components
  • mRNA processing
  • tRNA processing
  • Aminoacyl-tRNA synthetase biology
  • Ribosome biology

Published Papers (1 paper)

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Review

Open AccessReview
Cell Fate Control by Translation: mRNA Translation Initiation as a Therapeutic Target for Cancer Development and Stem Cell Fate Control
Biomolecules 2019, 9(11), 665; https://doi.org/10.3390/biom9110665 - 29 Oct 2019
Abstract
Translation of mRNA is an important process that controls cell behavior and gene regulation because proteins are the functional molecules that determine cell types and function. Cancer develops as a result of genetic mutations, which lead to the production of abnormal proteins and [...] Read more.
Translation of mRNA is an important process that controls cell behavior and gene regulation because proteins are the functional molecules that determine cell types and function. Cancer develops as a result of genetic mutations, which lead to the production of abnormal proteins and the dysregulation of translation, which in turn, leads to aberrant protein synthesis. In addition, the machinery that is involved in protein synthesis plays critical roles in stem cell fate determination. In the current review, recent advances in the understanding of translational control, especially translational initiation in cancer development and stem cell fate control, are described. Therapeutic targets of mRNA translation such as eIF4E, 4EBP, and eIF2, for cancer treatment or stem cell fate regulation are reviewed. Upstream signaling pathways that regulate and affect translation initiation were introduced. It is important to regulate the expression of protein for normal cell behavior and development. mRNA translation initiation is a key step to regulate protein synthesis, therefore, identifying and targeting molecules that are critical for protein synthesis is necessary and beneficial to develop cancer therapeutics and stem cells fate regulation. Full article
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