Mechanisms, Biology and Regulation of Proteasomes—in Memory of Professor Alfred L. Goldberg (1942–2023)
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 445
Special Issue Editors
Interests: biochemistry of proteasome function, regulation, and pathology; instruction in biochemistry and cell biology
Special Issue Information
Dear Colleagues,
As you are well aware, the study of proteasomes and how they mediate protein degradation has given us tremendous insights into multiple aspects of cell biology, physiology, and medicine. Fred Goldberg shaped and cheered on much of that work.
The publishers of Biomolecules have asked us to compile original research articles and reviews on the mechanisms, biology, and regulation of proteasomes to honor Goldberg’s memory and showcase how the study of proteasomes continues to shape many diverse fields.
Fred Goldberg’s insatiable curiosity and erudition led to his work shaping multiple aspects of the protein degradation machinery, especially the mechanisms, cell biology, and pharmacological targeting of the 26S proteasome. In this Special Issue, we will collect reviews and new articles that both reflect the influence of Goldberg’s work in these areas and promise to build on these areas in the future.
Thus, this Special Issue will focus on the structure and biochemical mechanisms of proteasomes, their role in cell biology, and the means of inhibiting or activating proteasomes using small-drug compounds. That said, we will limit the focus to proteasomes themselves and ignore Goldberg’s important work with bacterial proteases, except, perhaps, for a discussion of new avenues of research regarding Mycobacterial and Archaeal proteasomes.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Structure of the 26S proteasome;
- Proteasome-associated Dubs;
- Shuttling factors;
- Regulatory particles
- Immunoproteasomes;
- ATP consumption;
- Threonine active sites;
- Recognition of ubiquitin chains
- Mycobacterial and/or Archaeal proteasomes;
- Proteasomes and muscle atrophy;
- Proteasomes and antigen presentation;
- Proteasomes and NFκB signaling;
- Proteasomes and protein aggregates;
- Proteasomes and cell differentiation;
- Proteasomes and ER-associated degradation;
- Mutations of proteasomes in human disease;
- Proteasomes and synaptic plasticity;
- The proteasome bounce-back stress response;
- Proteasome inhibitors;
- Activation of proteasomes by phosphorylation;
- DUb inhibitors and proteasome flux.
We look forward to receiving your contributions.
Dr. Galen A. Collins
Dr. Alexander John Dear
Guest Editors
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Keywords
- proteasomes
- ubiquitin
- protease mechanisms
- protease inhibitors
- ATPases
- muscle atrophy
- antigen presentation
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