Hydrogen Sulfide and Polysulfides, Endogenous Mammalian Transmitters——Honorary Special Issue Commemorating the Work of Prof. Hideo Kimura
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (1 April 2022) | Viewed by 52701
Special Issue Editor
Interests: nitric oxide; peroxynitrite; poly(ADP-ribose) polymerase; reactive oxygen species; mitochondria; hydrogen sulfide; cell death; cancer; circulatory shock; acute lung injury; inflammation; reperfusion injury; down syndrome; bioenergetics
Special Issue Information
Dear Colleagues,
This year marks the 25th anniversary of the publication of Professor Hideo Kimura’s paper (J Neurosci, 16:1066, 1996), where he proposed that hydrogen sulfide (H2S) biosynthesis in the brain may serve as an endogenous neuromodulator. This paper stimulated the interest of many scientists to explore the biological roles of H2S, which, in previous centuries, was almost exclusively viewed strictly as an environmental toxin. In the past 25 years, intensive scientific work began to explore the biosynthesis and functional roles of H2S as an endogenous mammalian enzymatic product in health and disease. Professor Kimura remained on the forefront of these efforts, and pioneered, among others, some of the neurobiological and neuropathological roles of H2S, as well as the biological role of polysulfides, a group of related endogenous reactive regulatory species.
This Special Issue is focused on the role of H2S and polysulfides in the regulation of the various mammalian cells and tissues in health and disease. These roles include various transmitter and modulator roles in the nervous system, various regulatory roles in the cardiovascular system (modulation of vascular tone, angiogenesis, and cardiac function), in cellular metabolism, and in many other conditions in health and disease. The Special Issue begins with a short review of Professor Kimura’s contributions to the field, followed by original research articles and reviews on all aspects of the molecular mechanisms and functional action of H2S and polysulfides in health and disease.
Prof. Csaba Szabo
Guest Editor
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Keywords
- gaseous transmitters
- hydrogen sulfide
- polysulfides
- nervous system
- cardiovascular system
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