Special Issue "Hydrogen Sulfide and Polysulfides, Endogenous Mammalian Transmitters——Honorary Special Issue Commemorating the Work of Prof. Hideo Kimura"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 1 September 2021.

Special Issue Editor

Prof. Csaba Szabo
grade Website
Guest Editor
Section of Science and Medicine, University of Fribourg, Fribourg, Switzerlan
Interests: pharmacology; molecular medicine; hydrogen sulfide biology; poly(ADP-ribose) polymerase; nitric oxide; peroxynitrite; critical illness; mitochondria; bioenergetics; cancer; Down syndrome; inflammation; reperfusion injury; vascular biology

Special Issue Information

Dear Colleagues,

This year marks the 25th anniversary of the publication of Professor Hideo Kimura’s paper (J Neurosci, 16:1066, 1996), where he proposed that hydrogen sulfide (H2S) biosynthesis in the brain may serve as an endogenous neuromodulator. This paper stimulated the interest of many scientists to explore the biological roles of H2S, which, in previous centuries, was almost exclusively viewed strictly as an environmental toxin. In the past 25 years, intensive scientific work began to explore the biosynthesis and functional roles of H2S as an endogenous mammalian enzymatic product in health and disease. Professor Kimura remained on the forefront of these efforts, and pioneered, among others, some of the neurobiological and neuropathological roles of H2S, as well as the biological role of polysulfides, a group of related endogenous reactive regulatory species.

This Special Issue is focused on the role of H2S and polysulfides in the regulation of the various mammalian cells and tissues in health and disease. These roles include various transmitter and modulator roles in the nervous system, various regulatory roles in the cardiovascular system (modulation of vascular tone, angiogenesis, and cardiac function), in cellular metabolism, and in many other conditions in health and disease. The Special Issue begins with a short review of Professor Kimura’s contributions to the field, followed by original research articles and reviews on all aspects of the molecular mechanisms and functional action of H2S and polysulfides in health and disease.

Prof. Csaba Szabo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). The Special Issue Editor has the option to invite Feature Articles and reduce or waive this fee. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gaseous transmitters
  • hydrogen sulfide
  • polysulfides
  • nervous system
  • cardiovascular system

Published Papers

This special issue is now open for submission.
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