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Review

Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years

Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Yamaguchi 756-0884, Japan
Academic Editor: Csaba Szabo
Biomolecules 2021, 11(6), 896; https://doi.org/10.3390/biom11060896
Received: 20 May 2021 / Revised: 14 June 2021 / Accepted: 14 June 2021 / Published: 16 June 2021
Since the first description of hydrogen sulfide (H2S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H2S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H2S in the brain, suggesting that H2S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H2S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H2S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H2S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H2S have been subsequently demonstrated. Two additional pathways for the production of H2S with 3-mercaptopyruvate sulfurtransferase (3MST) from l- and d-cysteine have been identified. We also discovered that hydrogen polysulfides (H2Sn, n ≥ 2) are potential signaling molecules produced by 3MST. H2Sn regulate the activity of ion channels and enzymes, as well as even the growth of tumors. S-Sulfuration (S-sulfhydration) proposed by Snyder is the main mechanism for H2S/H2Sn underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H2S/H2Sn signaling during the first 25 years. View Full-Text
Keywords: hydrogen sulfide; polysulfides; S-sulfuration; nitric oxide; hydrogen peroxide; S-nitrosylation; S-sulfenylation; 3MST hydrogen sulfide; polysulfides; S-sulfuration; nitric oxide; hydrogen peroxide; S-nitrosylation; S-sulfenylation; 3MST
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MDPI and ACS Style

Kimura, H. Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years. Biomolecules 2021, 11, 896. https://doi.org/10.3390/biom11060896

AMA Style

Kimura H. Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years. Biomolecules. 2021; 11(6):896. https://doi.org/10.3390/biom11060896

Chicago/Turabian Style

Kimura, Hideo. 2021. "Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years" Biomolecules 11, no. 6: 896. https://doi.org/10.3390/biom11060896

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