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Potential Effects of Natural H2S-Donors in Hypertension Management

1
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
2
Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield S1 1WB, UK
3
Interdepartmental Research Centre “Nutraceuticals and Food for Health (NUTRAFOOD)”, University of Pisa, 56126 Pisa, Italy
4
Interdepartmental Research Centre of Ageing, Biology and Pathology, University of Pisa, 56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Csaba Szabo
Biomolecules 2022, 12(4), 581; https://doi.org/10.3390/biom12040581
Received: 10 March 2022 / Revised: 1 April 2022 / Accepted: 12 April 2022 / Published: 14 April 2022
After the discovery of hydrogen sulfide (H2S) in the central nervous system by Abe and Kimura in 1996, the physiopathological role of H2S has been widely investigated in several systems such as the cardiovascular. In particular, H2S plays a pivotal role in the control of vascular tone, exhibiting mechanisms of action able to induce vasodilation: for instance, activation of potassium channels (KATP and Kv7) and inhibition of 5-phosphodiesterase (5-PDE). These findings paved the way for the research of natural and synthetic exogenous H2S-donors (i.e., molecules able to release H2S) in order to have new tools for the management of hypertension. In this scenario, some natural molecules derived from Alliaceae (i.e., garlic) and Brassicaceae (i.e., rocket or broccoli) botanical families show the profile of slow H2S-donors able to mimic the endogenous production of this gasotransmitter and therefore can be viewed as interesting potential tools for management of hypertension or pre-hypertension. In this article, the preclinical and clinical impacts of these natural H2S-donors on hypertension and vascular integrity have been reviewed in order to give a complete panorama of their potential use for the management of hypertension and related vascular diseases. View Full-Text
Keywords: hydrogen sulfide; polysulfides; isothiocyanates; garlic; Alliaceae; Brassicaceae; hypertension hydrogen sulfide; polysulfides; isothiocyanates; garlic; Alliaceae; Brassicaceae; hypertension
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MDPI and ACS Style

Piragine, E.; Citi, V.; Lawson, K.; Calderone, V.; Martelli, A. Potential Effects of Natural H2S-Donors in Hypertension Management. Biomolecules 2022, 12, 581. https://doi.org/10.3390/biom12040581

AMA Style

Piragine E, Citi V, Lawson K, Calderone V, Martelli A. Potential Effects of Natural H2S-Donors in Hypertension Management. Biomolecules. 2022; 12(4):581. https://doi.org/10.3390/biom12040581

Chicago/Turabian Style

Piragine, Eugenia, Valentina Citi, Kim Lawson, Vincenzo Calderone, and Alma Martelli. 2022. "Potential Effects of Natural H2S-Donors in Hypertension Management" Biomolecules 12, no. 4: 581. https://doi.org/10.3390/biom12040581

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