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Biomolecules
Special Issues
Aging and Aging-Related Diseases in China
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Aging and Aging-Related Diseases in China

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (20 June 2022) | Viewed by 5298

Special Issue Editor

Dr. Yongzhang Luo

E-Mail Website
Guest Editor
The National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China
Interests: aging; diabetes; cardiovascular diseases; Alzheimer's disease; Parkinson's disease; albumin; Hsp90alpha

Special Issue Information

Dear Colleagues,

Longevity is an eternal pursuit of human beings. Tales of passionate seeking for immortality can be traced through the entirety of human history. Aging is a complex process related to damages to biomolecules. Many theories link the mechanism of aging to free radical-induced damages, molecular cross-linking, changes in immunological functions, telomere shortening, the presence of senescence genes in the DNA, and the performance of genetic maintenance and repair systems. In general, impairments of homeostasis lead to the accumulation of damaged biomolecules, including DNA, RNA, proteins, lipids, and small molecules in the aging organism, which can lead to aging-related diseases including Alzheimer's disease, cardiovascular diseases, diabetes mellitus, etc. It is of great significance to explore the mechanisms of aging and develop antiaging therapies from the viewpoint of biomolecules.

This Special Issue titled “Aging and aging-related diseases” invites original research articles, reviews, communications, and concept papers on the mechanism of aging and antiaging biomolecules. Papers in this issue will provide novel and evidence-based insights into the mechanism of aging and aging-related disorders, as well as potential antiaging biomolecules.

Dr. Yongzhang Luo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Aging；aging-related disease；antiaging therapy；senescence；damaged biomolecules；homeostasis

Published Papers (1 paper)

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Research

14 pages, 4079 KiB  
Article
Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice
by Jiaze Tang, Anji Ju, Boya Li, Shaosen Zhang, Yuanchao Gong, Boyuan Ma, Yi Jiang, Hongyi Liu, Yan Fu and Yongzhang Luo
Biomolecules 2021, 11(8), 1191; https://doi.org/10.3390/biom11081191 - 12 Aug 2021
Cited by 4 | Viewed by 4718
Abstract
Improvement of longevity is an eternal dream of human beings. The accumulation of protein damages is considered as a major cause of aging. Here, we report that the injection of exogenous recombinant mouse serum albumin (rMSA) reduced the total damages of serum albumin [...] Read more.
Improvement of longevity is an eternal dream of human beings. The accumulation of protein damages is considered as a major cause of aging. Here, we report that the injection of exogenous recombinant mouse serum albumin (rMSA) reduced the total damages of serum albumin in C57BL/6N mice, with higher level of free-thiols, lower levels of carbonyls and advanced glycation end-products as well as homocysteines in rMSA-treated mice. The healthspan and lifespan of C57BL/6N mice were significantly improved by rMSA. The grip strength of rMSA-treated female and male mice increased by 29.6% and 17.4%, respectively. Meanwhile, the percentage of successful escape increased 23.0% in rMSA-treated male mice using the Barnes Maze test. Moreover, the median lifespan extensions were 17.6% for female and 20.3% for male, respectively. The rMSA used in this study is young and almost undamaged. We define the concept “young and undamaged” to any protein without any unnecessary modifications by four parameters: intact free thiol (if any), no carbonylation, no advanced glycation end-product, and no homocysteinylation. Here, “young and undamaged” exogenous rMSA used in the present study is much younger and less damaged than the endogenous serum albumin purified from young mice at 1.5 months of age. We predict that undamaged proteins altogether can further improve the healthspan and lifespan of mice. Full article
(This article belongs to the Special Issue Aging and Aging-Related Diseases in China)
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