The Development of Translational Cancer Research: In Honor of a Pioneering Professor, Ulrik Ringborg

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 2245

Special Issue Editors


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Guest Editor
Cancer Center Karolinska (CCK), Karolinska University Hopsital, Visionsgatan 56, 171 64 Solna, Sweden
Interests: translational cancer research; tumor cell biology; invasion; metastasis; network medicine; precision cancer medicine; Epstein–Barr virus; nasopharngeal carcinoma

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Guest Editor
Department of Laboratory Medicine, Professor of Hematology and Cellular Therapy (LabMed), Karolinska Institutet and former Scientific Director of the Cancer Center, CAST, Karolinska Universitetsjukhuset, 141 86 Huddinge, Sweden
Interests: tumor immunology; transplantation biology; CAR-T cells; clinical trials

Special Issue Information

Dear Colleagues,

This Special Issue is published to honor Professor Ulrik Ringborg’s seminal work. It began around 1970, with a discovery phase in basic science with the Karolinska Institutet cell biology group, headed by Professor Jan-Erik Edström, devoted to transcription regulation in the giant chromosome Balbiani ring model of the mosquito Chironymus tentans.

Ulrik Ringborg moved to the clinic and in 1992 he was appointed Senior Consultant at the Department of General Oncology, Radiumhemmet, and Professor of Oncology at the Karolinska Institute. From 1993 he was Chairman of the Department of Oncology-Pathology, Head of the Oncology Clinic of the Karolinska Hospital, and later also Director of the Cancer Center Karolinska. During these years, he and his research group made seminal contributions to the understanding of the biology of malignant melanoma and established prevention and early detection programs, as well as immunotherapy.

He has served as a member of the Nobel Assembly and the Swedish Cancer Society. Ulrik Ringborg was also a member of the Scientific Advisory Committee of EORTC and Member of Policy Committee of ECCO—the European CanCer Organisation.

Early on, he identified the gap between the innovative basic/preclinical research at the Karolinska Institutet and the clinical research at the University Hospital, and therefore focused on structuring translational cancer medicine. He was involved in the establishment of a new concept, the Cancer Center Karolinska, a translational cancer research structure, and in the work of the Organisation of European Cancer Centres (OECI) to quality assure cancer care/research environments in terms of Comprehensive Cancer Centers. He argued that, to conquer the increasing and challenging cancer problem, personalized/precision cancer medicine (PCM) has to be based on international research collaborations and improved infrastructure support, as well as patients’ involvement. The European Academy of Cancer Sciences (EACS) is now the organisation with this focus and with the aim to join the European cancer organisations to a common vision and strategy. Between 2009 and 2023, Ulrik was the Secretary General of the EACS.

This Special Issue will focus on the most recent and seminal developments in this wide-ranging fields of translational cancer research and PCM.

It will address four themes: 1) Advances in cancer diagnosis and treatment. 2) Birth and Development of Precision Cancer Medicine (PCM). 3) Prevention. 4) Infrastructure for translational and clinical cancer research.

The authors, by invitation, will be leading colleagues in the field of cancer research, specifically translational and clinical cancer research, most of them opinion leaders from Ulrik Ringborg’s generation and younger.

Dr. Ingemar Ernberg
Prof. Dr. Stephan Mielke
Guest Editors

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Keywords

  • translational cancer research
  • tumor cell biology
  • precision cancer medicine

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Published Papers (2 papers)

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23 pages, 1413 KiB  
Review
Oncobiomics: Leveraging Microbiome Translational Research in Immuno-Oncology for Clinical-Practice Changes
by Carolina Alves Costa Silva, Andrew A. Almonte and Laurence Zitvogel
Biomolecules 2025, 15(4), 504; https://doi.org/10.3390/biom15040504 - 31 Mar 2025
Viewed by 478
Abstract
Growing evidence suggests that cancer should not be viewed solely as a genetic disease but also as the result of functional defects in the metaorganism, including disturbances in the gut microbiota (i.e., gut dysbiosis). The human microbiota plays a critical role in regulating [...] Read more.
Growing evidence suggests that cancer should not be viewed solely as a genetic disease but also as the result of functional defects in the metaorganism, including disturbances in the gut microbiota (i.e., gut dysbiosis). The human microbiota plays a critical role in regulating epithelial barrier function in the gut, airways, and skin, along with host metabolism and systemic immune responses against microbes and cancer. Collaborative international networks, such as ONCOBIOME, are essential in advancing research equity and building microbiome resources to identify and validate microbiota-related biomarkers and therapies. In this review, we explore the intricate relationship between the microbiome, metabolism, and cancer immunity, and we propose microbiota-based strategies to improve outcomes for individuals at risk of developing cancer or living with the disease. Full article
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13 pages, 2641 KiB  
Review
Perceptions of Cancer Through the Ages—From Hippocratic Oncology to Precision Cancer Medicine
by Spyros Retsas
Biomolecules 2024, 14(11), 1383; https://doi.org/10.3390/biom14111383 - 30 Oct 2024
Viewed by 1311
Abstract
The unravelling of the human genome created new perceptions of the origin and evolution of diseases, and for cancer in particular, it established the notion that neoplasia has been a companion of life since its appearance on Earth. It is not surprising that [...] Read more.
The unravelling of the human genome created new perceptions of the origin and evolution of diseases, and for cancer in particular, it established the notion that neoplasia has been a companion of life since its appearance on Earth. It is not surprising that neoplasms, in various forms, develop in numerous species of animals and even in plants. Unmistakable accounts of cancer with clinical features as are understood today begin in the 5th c. B.C. The principles and practice of the Hippocratic and Galenic tradition dominated cancer care virtually into the 20th century. Advanced sequencing technologies at the dawn of the 21st century generated new therapeutic opportunities with immunotherapy, oncolytic virotherapy, and gene transfer, with the latter especially being used in cases of hereditary cancer. Full article
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