Nutritional Deficiencies as a Driver of Inflammation: Molecular Mechanisms of Immune Defense

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 2477

Special Issue Editor


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Guest Editor
The interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Vienna, Austria
Interests: nutritional deficiencies; nutrients; minerals; cross feeding; microbes; inflammation; immune resilience; immune tolerance
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Special Issue Information

Dear Colleagues,

We are shaped by our environment, with our immune system being at the forefront of handling and discerning between harmful and harmless factors. Nutrition and immunity are closely intertwined, with microbial cross-feeding contributing to health. However, in the context of nutrient deficiencies, a veritable tug-of-war for these nutrients can ensue between the various organisms, which can tip the system towards disease, e.g., inflammation. Understanding the specific mechanisms and factors contributing to inflammation is essential to develop preventive or therapeutic measures that re-establish health or at least mitigate the disease course.

This Special Issue focuses on the recent scientific progress that enhances our understanding of nutrient-dependent immunoregulation and inflammation. Based on your expertise, we invite original reports, observations and reviews that identify (i) environmental contributors, (ii) pathways to immune activation, (iii) mechanisms of immunosuppression and tolerance induction and (iv) recent advances in novel prophylactic and therapeutic measurements.

Dr. Franziska Roth-Walter
Guest Editor

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Keywords

  • nutritional deficiencies
  • nutrients
  • minerals
  • cross feeding
  • microbes
  • inflammation
  • immune resilience
  • immune tolerance

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Published Papers (1 paper)

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Review

15 pages, 1306 KiB  
Review
Necrotizing Enterocolitis and Neurodevelopmental Impairments: Microbiome, Gut, and Brain Entanglements
by Cuilee Sha, Zhaosheng Jin, Stella Y. Ku, Ann S. Kogosov, Sun Yu, Sergio D. Bergese and Helen Hsieh
Biomolecules 2024, 14(10), 1254; https://doi.org/10.3390/biom14101254 - 4 Oct 2024
Cited by 2 | Viewed by 2025
Abstract
There is significant communication and interdependence among the gut, the microbiome, and the brain during development. Diseases, such as necrotizing enterocolitis (NEC), highlight how injury to the immature gastrointestinal tract leads to long-term neurological consequences, due to vulnerabilities of the brain in the [...] Read more.
There is significant communication and interdependence among the gut, the microbiome, and the brain during development. Diseases, such as necrotizing enterocolitis (NEC), highlight how injury to the immature gastrointestinal tract leads to long-term neurological consequences, due to vulnerabilities of the brain in the early stages of life. A better understanding of the developing gut–microbiota–brain axis is needed to both prevent and treat the devastating consequences of these disease processes. The gut–microbiota–brain axis is a bidirectional communication pathway that includes metabolic, nervous, endocrine, and immune components. In this review, we discuss gut development, microbiome colonization and maturation, and the interactions that influence neurodevelopment in the context of NEC. We describe the components of the gut–brain axis and how the microbiome is an integral member of this relationship. Finally, we explore how derangements within the microbiome and gut–microbiota–brain axis affect the normal development and function of the other systems and long-term neurodevelopmental consequences for patients. Full article
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