Novel Biomarkers of Kidney Diseases: Second Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".

Deadline for manuscript submissions: 15 May 2025 | Viewed by 1585

Special Issue Editors


E-Mail Website
Guest Editor
General University Hospital, Prague, Czech Republic
Interests: chronic kidney disease; renal biopsy; IgA nephropathy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of the second edition of the Special Issue entitled “Novel Biomarkers of Kidney Diseases”.

With the expanding therapeutic options for treating different chronic kidney diseases, there is an increasing need for the non-invasive diagnosis of glomerular disease and, even more importantly, the assessment of its activity, chronicity (degree of fibrosis), putative outcome, optimal choice and response to treatment. The increase in our understanding of the pathogenesis of chronic kidney disease has resulted in the identification of new potential therapeutic targets. Thus, the aim of this Special Issue is to provide an update on the recent progress in these two areas. We encourage authors to submit papers on the recent advances in biomarkers and the potential therapeutic targets of kidney disease.

Prof. Dr. Vladimír Tesař
Prof. Dr. Dita Maixnerova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarker
  • kidney disease
  • fibrosis
  • proteomics
  • metabolomics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 2207 KiB  
Article
Urinary Proteomic Shifts over Time and Their Associations with eGFR Decline in Chronic Kidney Disease
by Zhalaliddin Makhammajanov, Kamila Nurlybayeva, Zikrillo Artikov, Pavel Tarlykov, Mohamad Aljofan, Rostislav Bukasov, Duman Turebekov, Syed Hani Abidi, Mehmet Kanbay and Abduzhappar Gaipov
Biomolecules 2025, 15(1), 45; https://doi.org/10.3390/biom15010045 - 1 Jan 2025
Viewed by 1027
Abstract
Chronic kidney disease (CKD) is a progressive condition characterized by declining renal function, with limited biomarkers to predict its progression. The early identification of prognostic biomarkers is crucial for improving patient care and therapeutic strategies. This follow-up study investigated urinary proteomics and clinical [...] Read more.
Chronic kidney disease (CKD) is a progressive condition characterized by declining renal function, with limited biomarkers to predict its progression. The early identification of prognostic biomarkers is crucial for improving patient care and therapeutic strategies. This follow-up study investigated urinary proteomics and clinical outcomes in 18 CKD patients (stages 1–3) and 15 healthy controls using liquid chromatography–mass spectrometry and Mascot-SwissProt for protein identification. The exponentially modified protein abundance index (emPAI) was used for peptide quantification. Regression analyses were used to evaluate relationships between urinary proteins and the estimated glomerular filtration rate (eGFR), adjusting for proteinuria. At baseline, 171 proteins (median emPAI 86) were identified in CKD patients, and 271 were identified (median emPAI 47) in controls. At follow-up, 285 proteins (median emPAI 44.8) were identified in CKD patients, and 252 were identified (median emPAI 34.2) in controls. FBN1 was positively associated with eGFR, while FETUA showed a significant negative correlation at baseline. At follow-up, VTDB shifted from a negative baseline to a positive association with eGFR over time. CD44 and FBN1 shifted from a positive baseline to a negative association over time. These findings highlight VTDB, FBN1, and CD44 as potential prognostic biomarkers, providing insights into CKD progression and therapeutic targets. Full article
(This article belongs to the Special Issue Novel Biomarkers of Kidney Diseases: Second Edition)
Show Figures

Figure 1

Back to TopTop