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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Cell Signal Transduction

edited by

Wenjing Zhang

submission deadline 30 Sep 2026 | Viewed by 385 | Submission Open

Keywords: molecular interactions in signaling; phosphorylation and signal propagation; post-translational modifications; cross-talk between signaling pathways; cellular response to extracellular stimuli; metabolic regulation and signaling; signaling in cancer progression; inflammatory signaling pathways; role of signaling in stem cell differentiation; innovative imaging techniques for signaling

(This special issue belongs to the Section Cell Biology)

More than a Shield: The Secret Functions of Epithelial Cells in Homeostasis and Infections

edited by

Mohamed Ibrahem Elhawy

and Na Zhao

submission deadline 30 Sep 2026 | Viewed by 104 | Submission Open

Keywords: epithelial diversity; signaling; homeostasis; immunity; infection; microbiome; inflammation; cytokines; antimicrobial peptides

(This special issue belongs to the Section Medical Biology)

Bone Physiology and Development

edited by

Silviya Nikolova

Diana Toneva

and Yohei Abe

submission deadline 30 Sep 2026 | Viewed by 77 | Submission Open

Keywords: osteology; osteogenesis; bone growth; bone physiology; bone morphology; bone pathology; bone imaging

(This special issue belongs to the Section Physiology)

Gut Microbiome in Health and Disease (3rd Edition)

edited by

Hao Zhong

and

Fengqin Feng

submission deadline 30 Sep 2026 | Viewed by 69 | Submission Open

Keywords: gut microbiota; ‘ gut– X’ axis; dysbiosis; food nutrition; metabolites; type 2 diabetes mellitus; gut health; immunity

(This special issue belongs to the Section Microbiology)

The Molecular and Cellular Mechanisms of Lung Injury and Recovery

edited by Weiguo Chen, HongLong Ji and Ibra S. Fancher

submission deadline 30 Sep 2026 | Viewed by 58 | Submission Open

Keywords: acute lung injury; chronic lung injury; ARDS; fibrosis; allergy; mechanisms; therapy; infection; inflammation; endothelial barrier

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Molecular Mechanisms of Retina Development and Degeneration

edited by

Hélène Léger

submission deadline 30 Sep 2026 | Viewed by 36 | Submission Open

Keywords: retina; retinal development; retinal degeneration; molecular mechanisms; signaling pathways; genetic regulation; epigenetics; neuronal and glial interactions; neuroinflammation

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Pathogenic Mechanisms Involved in Development and Progression of ROS-Associated Diseases

edited by

Hye-Jin Park

submission deadline 30 Sep 2026 | Viewed by 27 | Submission Open

Keywords: Reactive Oxygen Species (ROS); oxidative stress; pathogenic mechanisms; disease progression; mitochondrial dysfunction; inflammation and immune regulation; redox biology; molecular signaling pathways; antioxidants and therapeutics; comparative medicine; One Health; translational research

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Innovative Approaches to Rice Crop Production Under Environmental Stresses

edited by

Chanakan Prom-u-thai

submission deadline 30 Sep 2026 | Viewed by 27 | Submission Open

Keywords: abiotic stress; environmental stress response; stress adaptation; DNA damage and repair; functional genomics; plant physiology; biofortification

(This special issue belongs to the Section Genetics and Genomics)

Semaphorins as Drivers of Inflammatory Disease: Setting Immune Cells in Motion

edited by

Tiago Granja

submission deadline 3 Oct 2026 | Viewed by 22 | Submission Open

Keywords: semaphorins; inflammation; neuronal guidance proteins; soluble guidance cues; cell motility; cytoskeletal dynamics; extracellular matrix

(This special issue belongs to the Section Immunology)

Molecular, Biophysical, and Neurophysiological Mechanisms Underlying Magnetoreception

edited by

Weidong Pan

and

Guijun Wan

submission deadline 30 Oct 2026 | Viewed by 84 | Submission Open

Keywords: earth magnetic field; magnetosensing; magnetite; radical pair; orientation; navigation; magnetic receptor; electroreceptor; neurophysiology

Fatty Acid Metabolism and Inflammation

edited by

Mi-hee Park

submission deadline 30 Oct 2026 | Viewed by 37 | Submission Open

Keywords: fatty acid metabolism; metabolic dysfunction; mitochondrial impairment; oxidative stress; glucose metabolism; lipid metabolism; Immune modulation; Inflammation; biomarkers

(This special issue belongs to the Section Physiology)

Mitochondria and Cardiovascular Diseases

edited by Qingxun Hu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1297 | Submission Open

Keywords: cardiovascular diseases; mitochondria; pathophysiology; cardiology; cell metabolism; animal models; epigenetics; redox biology

(This special issue belongs to the Section Physiology)

Brain Organoids: Construction, Analysis, and Application

edited by

Jonghun Kim

submission deadline 31 Oct 2026 | Viewed by 126 | Submission Open

Keywords: brain organoids; iPSCs; neurodevelopmental disorders; region-specific organoids; functional neuronal analysis

Advances in Plant Multi-Omics

edited by

Xiuzhang Li

, Zhonglong Guo and Xuekai Wei

submission deadline 31 Oct 2026 | Viewed by 98 | Submission Open

Keywords: multi-omics integration; plant systems biology; high-throughput sequencing; bioinformatics integration; stress response

(This special issue belongs to the Section Plant Science)

Current Advances in Cancer Genomics

edited by

Yuanxiang Li

submission deadline 31 Oct 2026 | Viewed by 41 | Submission Open

Keywords: cancer genomics; tumor heterogeneity; epigenomics; single-cell sequencing; multi-omics; genomic biomarkers; precision oncology; computational genomics; non-coding RNA; drug resistance

(This special issue belongs to the Section Cancer Biology)

Pathogenesis and Immune Evasion of Mycobacteria in Mammals

edited by Laura Klepp and Federico Carlos Blanco

submission deadline 31 Oct 2026 | Viewed by 16 | Submission Open

Keywords: mycobacteria; pathogenesis; immune evasion; host– pathogen interactions; latency; zoonotic transmission; comparative immunology; vaccine development; host-directed therapies

(This special issue belongs to the Section Immunology)

Decoding RNA Modifications in Cancer Biology

edited by Yutao Zhao

submission deadline 31 Oct 2026 | Viewed by 4 | Submission Open

Keywords: RNA modifications; epitranscriptomics; gene regulation; RNA biology; post-transcriptional regulation; N6-methyladenosine (m6A); pseudouridine (Ψ )

(This special issue belongs to the Section Cancer Biology)

Erythrocytes in Human Life—Functions Beyond Oxygen Transport

edited by

Vesna Ilic

and

Ivana Drvenica

submission deadline 15 Nov 2026 | Viewed by 117 | Submission Open

Keywords: erythrocytes in physiological processes; erythrocytes in disease pathophysiology; erythrocyte biomechanics; erythrocyte imaging; erythrocyte membrane; erythrocyte metabolism; haemoglobin; immune modulation; redox homeostasis

(This special issue belongs to the Section Cell Biology)

Genetics and Evolutionary Biology of Aquatic Organisms

edited by

Qianhong Gu

and Liang Guo

submission deadline 15 Nov 2026 | Viewed by 82 | Submission Open

Keywords: population genetics; conservation genetics; biodiversity; comparative genomics; polyploidization; rapid adaptation; population genetic divergence; thermal tolerance; hypoxia adaptation; deep-sea pressure adaptation; convergent evolution; molecular clock; phylogeography; population genetic structure; divergence time; inbreeding depression; genetic diversity; genomic selection; genome assembly; transcriptomics; population genomics

(This special issue belongs to the Section Evolutionary Biology)

Ecological Dynamics of Vector-Borne Pathogens: From Hosts to Vectors

edited by

Sofia Ferreira Anastácio

Joana Ferrolho Gibson

and Hugo C. R. Vilhena

submission deadline 30 Nov 2026 | Viewed by 63 | Submission Open

Keywords: vector-borne pathogens; host– vector interactions; climate change; disease emergence

(This special issue belongs to the Section Microbiology)

Stem Cell Stress Responses: Mechanisms, Models, and Implications

edited by Taku Kaitsuka

submission deadline 30 Nov 2026 | Viewed by 53 | Submission Open

Keywords: stem cells; stress response; differentiation; heat stress; hypoxic stress; oxidative stress; mechanical stress; proteotoxic stress; membrane protein; stress-inducible transcription factor

(This special issue belongs to the Section Cell Biology)

Bacterial Secretion Systems: Mechanisms, Regulation, and Their Roles in Microbe–Microbe and Microbe–Host Interactions

edited by

Lingfang Zhu

submission deadline 15 Dec 2026 | Viewed by 44 | Submission Open

Keywords: secretion system; pathogenicity; quorum sensing; expression and regulation; transcriptomics; environmental adaptability; microbial interaction mechanism

(This special issue belongs to the Section Microbiology)

Advances in Tropical Plant Ecology and Physiology

edited by Naysa Flávia Ferreira Do Nascimento and Edna Ursulino Alves

submission deadline 30 Dec 2026 | Viewed by 33 | Submission Open

Keywords: tropical plants; plant ecology; plant physiology; environmental adaptations; phenotypic diversity; climate change; biodiversity conservation; sustainable management

(This special issue belongs to the Section Plant Science)

Biology, Ecology and Management of Aquatic Macrophytes and Algae—2nd Edition

edited by

Jinlin Liu

Wei Liu

and Shuang Zhao

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3968 | Submission Open

Keywords: aquatic macrophytes and algae; ecological planning and management; harmful algal blooms and control; biological resources and environment; aquatic ecosystem stability; ecological restoration; biodiversity; plant physiology; biomarkers; symbiotic microorganisms

Cellular Senescence in Development, Regeneration, Aging, and Cancer

edited by

Selim Chaib

submission deadline 31 Dec 2026 | Viewed by 378 | Submission Open

Keywords: cellular senescence; aging; cancer; obesity; metabolism; geroscience; age-related diseases; SASP; senolytics; biomarkers

Advances in Biomechanics in Physiology and Pathology

edited by Chi Wei Ong and

Milan Toma

submission deadline 31 Dec 2026 | Viewed by 105 | Submission Open

Keywords: biomechanics; mechanics; extracellular matrix; cellular mechanics; tissue remodeling; developmental biomechanics; computational modeling; bioimaging; engineered microenvironments; artificial intelligence; machine learning

(This special issue belongs to the Section Biophysics)

Aquatic Economic Animal Breeding and Healthy Farming (2nd Edition)

edited by Yude Wang and Shengwei Luo

submission deadline 31 Dec 2026 | Viewed by 93 | Submission Open

Keywords: rice– fish; fish; and aquaculture; hybridization and genetic breeding; nutrient additive and requirement; physiology and immune response; disease control; pathogenesis research; probiotic identification and function; transcriptomics; proteomics; metabonomics

(This special issue belongs to the Section Zoology)

Advances in Biological Research into Shrimps, Crabs and Lobsters (2nd Edition)

edited by Lutz Auerswald

submission deadline 31 Dec 2026 | Viewed by 35 | Submission Open

Keywords: Crustacea; Decapoda; biology; fishery; aquaculture; ecology; bio-compounds; seafood; physiology; immunology; genetics

(This special issue belongs to the Section Zoology)

From Cell Division to Systemic Dysregulation: Genetic Mechanisms and Biomarkers in Civilization Diseases

edited by

Robert Zdanowski

and

Agata Borkowska

submission deadline 31 Dec 2026 | Viewed by 25 | Submission Open

Keywords: cell cycle regulation; genetic and epigenetic mechanisms; cellular senescence; oxidative stress; inflammation; molecular biomarkers; neurodegeneration; tumor microenvironment; metabolic and cardiovascular diseases

(This special issue belongs to the Section Cell Biology)

Metabolic and Stress Responses in Aquatic Animals (2nd Edition)

edited by