Tumor Biomechanics and Mechanobiology

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 860

Special Issue Editor


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Guest Editor
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
Interests: biomechanics; tumor cell microenvironment; macrophages; stem cell; genetics and genomics; molecular biology

Special Issue Information

Dear Colleagues,

Many studies have revealed the important role of mechanical forces in the progression of tumors. The interplay between mechanical and biochemical cues affects the function and behavior of tumor cells during the development of solid tumors, especially their metastatic potential. Based on the above information, clarifying mechanobiological transduction is beneficial in achieving a more systematic and comprehensive understanding of the complex regulatory network in the tumor microenvironment and is important in further research on how the mechanical microenvironment in the tumor affects the process of tumor occurrence and development.

We are pleased to invite you to submit relevant papers to our Special Issue, “Tumor Biomechanics and Mechanobiology”. We encourage submissions that investigate the migration, invasion, metastasis, and apoptosis of tumor cells and explore their mechanobiological role in tumor process, as well as their applications, such as in small molecules or gene-targeting entities in treating cancer.

This Special Issue will provide a platform for researchers to share their findings and contribute to the growing body of knowledge in pioneering research on the roles and mechanisms of biomechanics in tumor progression and innovative applications of cancer therapeutics in disease management.

For this Special Issue, submissions of original research articles and reviews are welcome. Research fields of interest include, but are not limited to, cancer biology, cell biology, genetics and genomics, and molecular biology.

I look forward to receiving your contributions.

Dr. Xinbin Zhao
Guest Editor

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Keywords

  • tumor migration
  • cancer cell invasion
  • cancer metastasis
  • biomechanics
  • tumor microenvironment
  • extracellular matrix
  • matrix degradation

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Published Papers (1 paper)

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Review

34 pages, 1707 KB  
Review
Mimicking Gastric Cancer Collagen Reorganization with Decellularized ECM-Based Scaffolds
by Néstor Corro, Sebastián Alarcón, Ángel Astroza, Roxana González-Stegmaier and Carolina Añazco
Biology 2025, 14(8), 1067; https://doi.org/10.3390/biology14081067 - 16 Aug 2025
Viewed by 652
Abstract
The tumor microenvironment (TME) has a substantial impact on the progression of gastric cancer. Collagen, the most abundant protein in the extracellular matrix (ECM), forms a dense physical barrier that regulates anti-tumor immunity in the TME. It is a significant regulator of the [...] Read more.
The tumor microenvironment (TME) has a substantial impact on the progression of gastric cancer. Collagen, the most abundant protein in the extracellular matrix (ECM), forms a dense physical barrier that regulates anti-tumor immunity in the TME. It is a significant regulator of the signaling pathways of cancer cells, which are responsible for migration, proliferation, and metabolism. ECM proteins, particularly remodeling enzymes and collagens, can be modified to increase stiffness and alter the mechanical properties of the stroma. This, in turn, increases the invasive potential of tumor cells and resistance to immunotherapy. Given the dynamic nature of collagen, novel therapeutic strategies have emerged that target both collagen biosynthesis and degradation, processes that are essential for addressing ECM stiffening. This review delineates the upregulation of the expression and deposition of collagen, as well as the biological functions, assembly, and reorganization that contribute to the dissemination of this aggressive malignancy. Furthermore, the review emphasizes the importance of creating 3D in vitro models that incorporate innovative biomaterials that avoid the difficulties of traditional 2D culture in accurately simulating real-world conditions that effectively replicate the distinctive collagen microenvironment. Ultimately, it investigates the use of decellularized ECM-derived biomaterials as tumor models that are designed to precisely replicate the mechanisms associated with the progression of stomach cancer. Full article
(This article belongs to the Special Issue Tumor Biomechanics and Mechanobiology)
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