Pathophysiological Role of Neuroinflammation in Neurodegenerative Disorders
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".
Deadline for manuscript submissions: 31 March 2027 | Viewed by 514
Special Issue Editors
Interests: neuroinflammation; neurodegeneration; natural compounds; pharmacological modulators of CNS
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroinflammation has emerged as a central player in the initiation and progression of neurodegenerative disorders, contributing to synaptic dysfunction, neuronal loss, and impaired brain homeostasis. Growing evidence highlights the pathological interplay between glial activation, cytokine signaling, oxidative stress, and blood–brain barrier alterations in driving chronic neuroinflammatory responses. Understanding these mechanisms is crucial not only for clarifying disease etiology but also for identifying innovative therapeutic strategies.
We invite you to contribute to this Special Issue, which will provide an updated and comprehensive overview of the pathophysiological role of neuroinflammation in neurodegenerative diseases.
This Special Issue will gather advances in mechanistic insights and molecular pathways targeting neuroinflammatory processes in disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and other CNS conditions. The topic is fully aligned with the journal's scope, as it focuses on the molecular and cellular basis of neurological pathologies, along with the development of pharmacological and natural modulators of CNS inflammation.
In this Special Issue, original research articles, full reviews, systematic reviews, and meta-analyses are welcome. Research areas may include, but are not limited to, the following:
- Mechanisms of neuroinflammation in neurodegenerative disorders;
- Crosstalk between microglia, astrocytes, and neurons;
- Cytokine networks and inflammatory mediators;
- Blood–brain barrier dysfunction and neurovascular alterations;
- Oxidative stress and mitochondrial impairment;
- Natural compounds and phytochemicals targeting neuroinflammatory pathways;
- Pharmacological modulators of CNS inflammation;
- Immunometabolism and neuroimmune signaling;
- Biomarkers of neuroinflammation.
We look forward to receiving your contributions.
Dr. Alessio Ardizzone
Dr. Deborah Mannino
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neuroinflammatory pathways
- neurodegenerative disorders
- microglia activation
- cytokines and chemokines
- neuroimmune biomarkers
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