Special Issues

Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biological Rhythms and Molecular Clockworks in Physiology and Pathology submission deadline 30 Sep 2025 | 10 articles | Viewed by 32606 | Submission Open
Keywords: biological rhythms; molecular clockworks; circadian timing system; circadian desynchrony; circadian disruption; chronopathology; chronopharmacology and chronotherapeutics; chronomedicine
(This special issue belongs to the Section Physiology)
Research Progress on Melanocytes and Melanin
edited by Zeina Tannous
submission deadline 30 Sep 2025 | Viewed by 502 | Submission Open
Keywords: melanin; melanocytes; melanocyte stem cell; pigmentation; melanoma; dysplastic nevi; vitiligo; melasma
(This special issue belongs to the Section Medical Biology)
The Role of Innate Immunity in Organ Transplantation
edited by Todd V. Brennan
submission deadline 30 Sep 2025 | Viewed by 379 | Submission Open
Keywords: innate immunity; allograft rejection; transplantation; immune tolerance
(This special issue belongs to the Section Medical Biology)
Physiology and Ecology of Animal Parasites and Related Diseases
edited by Marcela K. Castelo
submission deadline 30 Sep 2025 | Viewed by 355 | Submission Open
Keywords: parasites; parasitoids; physiology; ecology; ecophysiology; diseases; global change
(This special issue belongs to the Section Zoology)
Island Ecology and Biodiversity: Managing the Effects of Climate and Land-Use Change
edited by Kealohanuiopuna Mark Kinney and Susan Cordell
submission deadline 30 Sep 2025 | Viewed by 291 | Submission Open
Keywords: island biogeography; biodiversity conservation; invasive species management; biocultural approaches; ecosystem resilience; landscape ecology; environmental sustainability; climate adaptation; social– ecological systems; restoration ecology       TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Ecology)
Metabolic Interactions between the Gut Microbiome and Host
edited by and
submission deadline 30 Oct 2025 | 6 articles | Viewed by 10979 | Submission Open
Keywords: gut microbiome; host; metabolome; microbial heterogeneity; biomolecules
(This special issue belongs to the Section Microbiology)
Multi-omics Approaches in Agricultural Crops to Unravel Responses to Environmental Stresses and Advance Sustainable Agriculture
edited by
submission deadline 30 Oct 2025 | 2 articles | Viewed by 3692 | Submission Open
Keywords: plant functional genomics; environmental stress; climate change; crop yield; crop quality; nutritional properties; omics approaches; genomics; transcriptomics; proteomics; metabolomics; epigenomics; phenomics; stress-tolerant crops; breeding strategies; data integration; systems biology; sustainable agriculture; underutilized crops; orphan crops; beneficial microorganisms
(This special issue belongs to the Section Plant Science)
Pathophysiology of Hearing Loss
edited by Charles E. Bishop
submission deadline 30 Oct 2025 | Viewed by 292 | Submission Open
Keywords: hearing loss; cochlea; noise; deafness genes; cell death; hair cells; inner ear; biotoxicity; metabolic risk; gene mutation; physiology and pathophysiology; animal models; biomarkers and molecular mechanisms
(This special issue belongs to the Section Physiology)
Advances in the Fields of Neurotrauma and Neuroregeneration submission deadline 31 Oct 2025 | 8 articles | Viewed by 45857 | Submission Open
Keywords: neurotrauma; spinal cord injury; traumatic brain injury; neuropathic pain; neuroinflammation; axonal regeneration; postinjury plasticity; neurorehabilitation; cell transplantation
(This special issue belongs to the Section Neuroscience)
Young Researchers in Neuroscience
edited by Yansheng Du
submission deadline 31 Oct 2025 | 3 articles | Viewed by 22920 | Submission Open
Keywords: neurobiology; cell biology; molecular mechanisms; neural development; synaptic function; ion channels; neurotransmitter systems; gene expression; neuronal signaling; cellular physiology
(This special issue belongs to the Section Neuroscience)
Progress in Wildlife Conservation, Management and Biological Research
edited by Ana Carolina Srbek-Araujo
submission deadline 31 Oct 2025 | 7 articles | Viewed by 7098 | Submission Open
Keywords: adaptive capacity; climate change; conservation opportunities; species vulnerability; threatened species; wildlife conservation; wildlife management
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Immunosenescence and Its Modification by Interventions
edited by and Luca Pangrazzi
submission deadline 31 Oct 2025 | 1 articles | Viewed by 4875 | Submission Open
Keywords: immunosenescence; aging immune system; inflammaging; vaccine efficacy in elderly; nutritional immunomodulation; exercise and immunity; senolytic therapies; T-cell exhaustion; thymic rejuvenation; age-related diseases
(This special issue belongs to the Section Immunology)
Pathogen-Host Interaction and Vaccine/Drug Design
edited by Iga Kucharska
submission deadline 31 Oct 2025 | 1 articles | Viewed by 2646 | Submission Open
Keywords: infectious diseases; host– pathogen interactions; vaccine; drug design; immune evasion; immunogen
(This special issue belongs to the Section Medical Biology)
Advances in Omics Approaches for Understanding Metabolic Disorders: Environmental and Nutritional Perspectives
edited by Yue Ge
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1167 | Submission Open
Keywords: metabolic disorders; environmental exposures; nutritional factors; omics technologies; co-exposures; cumulative toxicity; metabolic pathways; human health risk assessment; advanced in vitro models; systems toxicology
(This special issue belongs to the Section Physiology)
Extracellular Vesicles: Biogenesis and Functions in the Complex Landscape of Differentiation and Disease
edited by
submission deadline 31 Oct 2025 | Viewed by 500 | Submission Open
Keywords: stem cell biology; stem cell differentiation; adipogenesis; neurogenesis; extracellular vesicles in stem cell differentiation; ncRNAs; tumor microenvironment; intercellular communication
(This special issue belongs to the Section Cell Biology)
Plant-Microbe Interaction: The Cellular Mechanism Influence Plant Health
edited by and Gongjun Shi
submission deadline 31 Oct 2025 | Viewed by 450 | Submission Open
Keywords: plant-microbe interaction; plant health; plant immunity; gene-for-gene model; resistosomes; metabolic crosstalk; climate change
Transcriptional Regulation in Eukaryotes
edited by Anil Kumar Panigrahi
submission deadline 31 Oct 2025 | Viewed by 398 | Submission Open
Keywords: transcription factors (TFs); transcriptional coregulators; RNA polymerase II; chromatin modifications and remodeling; enhancers; silencers; non-coding RNAs; 3D chromatin architecture; multi-omics integration; single-cell technologies
(This special issue belongs to the Section Genetics and Genomics)
Advancing Molecular Mechanisms and Therapeutic Innovations in Neurodegenerative Diseases
edited by Tao Yang
submission deadline 31 Oct 2025 | Viewed by 238 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer's disease; amyotrophic lateral sclerosis; Parkinson's disease; Huntington's disease; frontotemporal dementia; small molecules; synaptic dysfunction; neuroinflammation; biomarkers
(This special issue belongs to the Section Neuroscience)
DNA Repair and DNA Damage Response (DDR) in Oncology
edited by
submission deadline 31 Oct 2025 | Viewed by 184 | Submission Open
Keywords: DNA repair and DNA damage response pathways; cancer target therapy; DNA replication stress response in genome stability; oxidative stress response and redox regulation; DNA single-strand break repair and signaling
(This special issue belongs to the Section Cancer Biology)
2nd Edition: Conservation and Evolution of Wildlife in the Context of Climate Change and Human Population Growth
edited by
submission deadline 1 Nov 2025 | 2 articles | Viewed by 1412 | Submission Open
Keywords: changes; local temperature; adaptation; evolution; animals; plants
(This special issue belongs to the Section Behavioural Biology)
Lysosomes and Diseases Associated with Its Dysfunction submission deadline 15 Nov 2025 | 4 articles | Viewed by 18841 | Submission Open
Keywords: activities; mutations; endocytosis; autophagy; metabolism; proteins
(This special issue belongs to the Section Cell Biology)
Biological Nitrogen Removal in the Multi-Omics Era: Coupling Anammox with Microbial-Mineral Synergy
edited by Zhaoming Zheng, and
submission deadline 25 Nov 2025 | Viewed by 184 | Submission Open
Keywords: sustainable nitrogen removal processes; anaerobic ammonium oxidation; aerobic granular sludge; microbial– mineral interactions; multi-omics microbial analysis; bioengineering in wastewater treatment; nitrogen biogeo-chemical cycle; detection and removal of emerging pollutants; water quality assurance technologies; resource re-covery from wastewater
(This special issue belongs to the Section Microbiology)
Unraveling the Tumor-Immune Microenvironment Using Transcriptomics submission deadline 30 Nov 2025 | 2 articles | Viewed by 3694 | Submission Open
Keywords: tumor-immune microenvironment; immune cells; tumor cells; stromal cells; signaling molecules; extracellular matrix (ECM); vascular network
(This special issue belongs to the Section Cancer Biology)
Physiology and Pathophysiology of the Kidney
edited by Gang Liu
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3676 | Submission Open
Keywords: renal physiology; renal hemodynamics; kidney injury; regenerative therapies; urology
(This special issue belongs to the Section Physiology)
Regulatory Mechanisms of Plant Stress Response
edited by and Li Ren
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3477 | Submission Open
Keywords: gene; gene expression; gene function; molecular regulation; genetic resource; phenotype; stress response
(This special issue belongs to the Section Genetics and Genomics)
Germ, Sertoli and Leydig Cells in the Testis
edited by and María Fernanda Riera
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2960 | Submission Open
Keywords: Sertoli cells; Leydig cells; spermatogonia; spermatocytes; spermatozoa; stem cell niche; testis; omics analysis; environmental toxicants; non-coding RNAs  
(This special issue belongs to the Section Cell Biology)
Mitochondrial Dysfunction and Aging
edited by Huiliang Zhang
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2410 | Submission Open
Keywords: mitochondrial dysfunction; aging; cardiovascular diseases; Alzheimer’ s disease and related dementia; stem cell; skeletal muscle; kidney
(This special issue belongs to the Section Medical Biology)
Genetics and Cell Biology in Crop Improvement
edited by , , Jie Huang and Xixi Liu
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1976 | Submission Open
Keywords: plant genomics and genetics; gene cloning and function; crop molecular breeding; germplasm enhancement; genetic engineering; plant cell biology; crop adaptability
(This special issue belongs to the Section Plant Science)
Advances in Redox Metabolism and Cellular Homeostasis submission deadline 30 Nov 2025 | 1 articles | Viewed by 1417 | Submission Open
Keywords: oxidative stress; peroxiredoxins; hydrogen peroxide; redox regulation; thiol modification; reactive oxygen species; iron sulfur clusters; redox signaling
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Diet and Environmental Stress Impacts on Farm Animal Production
edited by and Michael Chimonyo
submission deadline 30 Nov 2025 | Viewed by 899 | Submission Open
Keywords: animal production; feed types; feed preparation; feed additives; diet quality and palatability; climate variability; housing environment
(This special issue belongs to the Section Zoology)
Managing Hybridizing Populations: Threats or Opportunities for Conservation?
edited by and Marco Musiani
submission deadline 30 Nov 2025 | Viewed by 707 | Submission Open
Keywords: natural hybridization; anthropogenic hybridization; adaptive introgression; hybrid fitness; coexistence of wildlife and free-ranging domestic animals; management of hybridizing populations
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Exposure to Heavy Metals: Advances in Cytotoxicity and Genotoxicity
edited by Qianru Chi and Yi Zhao
submission deadline 30 Nov 2025 | Viewed by 465 | Submission Open
Keywords: heavy metal pollutants; exposure assessment; toxic mechanism; biomarkers; metabolomics; environmental quality monitoring; bioinformatics analysis methods
(This special issue belongs to the Section Toxicology)
Heavy Metal Pollution and Bioremediation: Application and Mechanism
edited by , Ruiyu Lin and Rongfei Wei
submission deadline 30 Nov 2025 | Viewed by 400 | Submission Open
Keywords: heavy metal pollutants; microbial remediation; phytoremediation; animal remediation; plant– soil– microbe interactions; enhanced remediation; combined remediation; hyperaccumulator plants; microbial-induced calcium carbonate precipitation
(This special issue belongs to the Section Toxicology)
Current Research in the Biodiversity, Ecology, and Evolution of Chondrichthyan Fishes (Sharks, Rays and Chimaeras)
edited by , and João Paulo Capretz Batista da Silva
submission deadline 30 Nov 2025 | Viewed by 337 | Submission Open
Keywords: Chondrichthyes; Elasmobranchii; Holocephali; sharks; skates; rays; chimaeras; chimaeras; biodiversity; taxonomy; systematics; ecology; evolution
(This special issue belongs to the Section Marine Biology)
Breast Cancer: Molecular and Cellular Mechanism and Biomarkers submission deadline 30 Nov 2025 | Viewed by 318 | Submission Open
Keywords: breast cancer; biomarkers; molecular mechanisms; multidrug resistance; personalized medicine; molecular targeted therapy; gene expression
(This special issue belongs to the Section Cancer Biology)
Exploring the Molecular Basis of Cancer: Perspectives from Genetics and Epigenetics
edited by
submission deadline 30 Nov 2025 | Viewed by 313 | Submission Open
Keywords: cancer genetics; epigenetics; tumor heterogeneity; histone modification; next-generation sequencing (NGS); cancer transcriptomics; gene regulation; mouse model; chromatin remodeling; CHIP-Seq; ATAC-seq; mutation; amplification
(This special issue belongs to the Section Genetics and Genomics)
Biological Foundations of Psychiatric Disorders
edited by Rammohan Shukla
submission deadline 30 Nov 2025 | Viewed by 221 | Submission Open
Keywords: psychiatric disorders; molecular mechanisms; animal models; therapeutic discovery; genetic associations; sex differences; protocols; methods; behavioral studies; stress-related phenotypes
(This special issue belongs to the Section Neuroscience)
Pathophysiology of Chronic Inflammatory Diseases
edited by Vincent Yuan
submission deadline 1 Dec 2025 | 3 articles | Viewed by 3724 | Submission Open
Keywords: chronic inflammation; autoimmune diseases; cytokines; inflammasome; metabolic dysfunction; oxidative stress; biomarkers; epigenetics; personalized medicine; therapeutic targets
(This special issue belongs to the Section Physiology)
Plant Epigenetics: Advancing Adaptation Strategies for Climate Change
edited by Qingzhu Zhang, and
submission deadline 1 Dec 2025 | 1 articles | Viewed by 1650 | Submission Open
Keywords: mechanistic insights into epigenetic regulation; epigenetic memory and transgenerational inheritance; advances in epigenetic tools and techniques; epigenomics and phenotypic plasticity; implications for agriculture and conservation; tree epigenetic responses to climate change
(This special issue belongs to the Section Plant Science)
Global Fisheries Resources, Fisheries, and Carbon-Sink Fisheries submission deadline 15 Dec 2025 | 21 articles | Viewed by 17927 | Submission Open
Keywords: fisheries; habitats; overfishing; fishery resource biology; economic aquatic animal behavior; stock enhancement by releasing; environmental DNA; fisheries management; climate change; ecosystems; ecological models; carbon-sink; aquatic ecological ranches; fisheries products
Biogeochemical Element Cycling in Plant–Soil Systems: Implications for Ecosystem Dynamics and Services
edited by and Wajid Zaman
submission deadline 15 Dec 2025 | 8 articles | Viewed by 14281 | Submission Open
Keywords: autotrophs; biomass production; climate stabilization; ecosystem functions; ecosystem management; ecosystem policy; global change; heterotrophs; pollination; soil fertility; soil macro-organisms; soil micro-organisms
(This special issue belongs to the Section Ecology)
Environmental DNA (eDNA) for Assessment of Coastal Marine Biodiversity submission deadline 15 Dec 2025 | 2 articles | Viewed by 1993 | Submission Open
Keywords: eDNA metabarcoding; coastal marine ecosystems; biodiversity; genetic distances; ecological indicators
(This special issue belongs to the Section Ecology)
Recent Advances in Understanding Systemic Lupus Erythematosus Pathogenesis
edited by Rohit Upadhyay
submission deadline 15 Dec 2025 | Viewed by 234 | Submission Open
Keywords: systemic lupus erythematosus (SLE); autoimmunity; immune dysregulation; B and T cell biology; interferon signaling; autoantibodies; epigenetics; biomarkers; therapeutic targets; systems immunology
(This special issue belongs to the Section Medical Biology)
Biology of Liver Diseases submission deadline 20 Dec 2025 | 3 articles | Viewed by 11330 | Submission Open
Keywords: viral hepatitis; alcoholic hepatitis; non-alcoholic steatohepatitis; autoimmune hepatitis; primary biliary cholangitis; liver cirrhosis; liver cancer; portal hypertension
(This special issue belongs to the Section Medical Biology)
Impacts of Climate Change on Terrestrial Carbon Cycling and Biodiversity Across Spatial and Temporal Scales submission deadline 21 Dec 2025 | 1 articles | Viewed by 1203 | Submission Open
Keywords: climate change; terrestrial carbon cycling; biodiversity; spatial and temporal scales; ecosystem resilience; UN CBD; UN Decade on Ecosystem Restoration; responsible business; nature-based solutions; sustainable development
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Computational Modeling of Drug Delivery
edited by and Arezoo M. Ardekani
submission deadline 25 Dec 2025 | 2 articles | Viewed by 2588 | Submission Open
Keywords: computational modeling; drug delivery; computational fluid dynamics; biofluids; quantitative biotransport; mathematical models; artificial intelligence
(This special issue belongs to the Section Biophysics)
Experimental Biology 100 Years After the Foundation of the Italian Society: A Celebratory Special Issue submission deadline 31 Dec 2025 | 14 articles | Viewed by 39594 | Submission Open
Keywords: anatomy; histology; embryology; physiology; biochemistry; cell biology; genetics; pharmacology; anthropology; cancerology; pathology; microbiology; advanced microscopy and imaging; aging; aquatic environments; artificial intelligence applied to biomedicine; biodiversity and modeling; biology of reproduction and infertility; biomedical and pharmaceutical biotechnology; cellular stress; environment and health; micro- and nanovesicles in biomedicine; neuroscience; nutrition and food supplements; plant biology; precision medicine; regenerative medicine; structural biology; urban biodiversity and climate change
Adaptation of Living Species to Environmental Stress
edited by and Sonia Del Prete
submission deadline 31 Dec 2025 | 10 articles | Viewed by 27991 | Submission Open
Keywords: adaptation; environmental stress; evolutionary response; physiological adaptation; behavioral adaptation; morphological adaptation; climate change; conservation biology; biodiversity; ecological resilience; sound waves
(This special issue belongs to the Section Ecology)
Physiology and Pathophysiology of Obesity
edited by Yifei Kang
submission deadline 31 Dec 2025 | 9 articles | Viewed by 26501 | Submission Open
Keywords: dietary intervention; alternative food; food supplementation; weight loss; weight management; obesity comorbidities; obesity pathophysiology
(This special issue belongs to the Section Physiology)
Innovative Biotechnologies for Advancing Protein Function Investigation
edited by Yongjuan Zhao, Wanhua Li and Qiwen Deng
submission deadline 31 Dec 2025 | 6 articles | Viewed by 25035 | Submission Open
Keywords: protein imaging and visualization; high-throughput screening; computational methodologies; protein engineering; protein– protein interactions; protein– ligand interactions; biological mechanisms
(This special issue belongs to the Section Biotechnology)
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