Redefining Structure–Function Relationships in Biomacromolecules

Dear Colleagues,

Since the discovery of the DNA structure by Watson and Crick, the structures of biomacromolecules, including proteins, nucleic acids, lipids, etc., have been an integral part of studying these biomolecules. Classical biology relied on a single, well-defined 3D structure and recent advances across structural biology, biophysics and cell biology showed that conformational dynamics, intrinsic disorder, transient interactions and cellular context are integral to bio-macromolecular function. Similarly, recent drug developments have shown that other factors, on top of static structures, like dynamic conformational landscapes, transient binding pockets and context-dependent target states, are key determinants of drug efficacy and resistance.

This Special Issue aims to redefine structure-function relationships in proteins, nucleic acids and other biomacromolecular assemblies, such as protein–DNA/RNA interactions and we welcome contributions of original research, short communications and review manuscripts emphasizing how biological function emerges from structural plasticity/heterogeneity and from the interactions between biomacromolecules such as proteins and nucleic acids. The contributions on novel structure-based strategies for therapeutic intervention, emphasizing the roles of structural biology, computational modeling and biophysics, are also welcome.

Dr. Hunmin Jung
Guest Editor

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