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Bioengineering
Special Issues
Novel and Advanced Technologies for Orthopaedic Implant
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Novel and Advanced Technologies for Orthopaedic Implant

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 5779

Special Issue Editors

Dr. Ioannis Gkiatas

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
Interests: general orthopaedics; adult reconstruction; trauma; periprosthetic joint infections; hand surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Dimitrios V. Papadopoulos

E-Mail Website
Guest Editor
Academic Department of Orthopaedics, School of Medicine, Konstandopoulio General Hospital, National & Kapodistrian University of Athens, Athens, Greece
Interests: orthopedics; musculoskeletal infections; hand surgery; musculoskeletal trauma; spine diseases
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ioannis D. Gelalis

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
Interests: orthopedics; arthroplasty; low back pain; biomechanics; spine surgery

Special Issue Information

Dear Colleagues,

The majority of orthopaedic procedures require the use of implants. Orthopaedic implants are used in both emergency and scheduled operations. Modern orthopaedic surgery techniques involve a variety of new designs of implants, which may provide improved outcomes. There is also extended research regarding new implants, their materials, and how these may affect the result of an orthopaedic operation.

This Special Issue on novel and advanced technologies for orthopaedic implants addresses the innovations in orthopaedic implants—not only those that are already in clinical use, but also implants or devices that are in the experimental stage. Submissions may address any of the fields of orthopaedic surgery, such as adult reconstruction, trauma, hand surgery, spine surgery, and others. We would like to welcome all your submissions and hope for a successful Special Issue.

Dr. Ioannis Gkiatas
Dr. Dimitrios V. Papadopoulos
Prof. Dr. Ioannis D. Gelalis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomechanics
  • survivorship
  • novelty
  • innovation
  • orthopaedic surgery
  • bioengineering

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

18 pages, 11695 KiB  
Article
Proof of Concept of a New Revision Procedure for Ceramic Inlays of Acetabular Cups Using a Shape-Memory Alloy Actuator System
by Christian Rotsch, Karoline Kemter-Esser, Johanna Dohndorf, Kerstin Funke, Christoph-Eckhard Heyde and Welf-Guntram Drossel
Bioengineering 2024, 11(9), 868; https://doi.org/10.3390/bioengineering11090868 - 27 Aug 2024
Viewed by 1232
Abstract
The revision of ceramic inlays of acetabular cups is a challenging surgical procedure. The mechanical impact during the inlay extraction process can damage the ceramic or metal cup rim. To avoid these risks, a concept for a new revision procedure was developed. It [...] Read more.
The revision of ceramic inlays of acetabular cups is a challenging surgical procedure. The mechanical impact during the inlay extraction process can damage the ceramic or metal cup rim. To avoid these risks, a concept for a new revision procedure was developed. It is based on an actuator system, which allows a non-destructive release of the ceramic inlay. To integrate the actuator system, different design concepts of acetabular cup components were investigated, and an actuator based on shape-memory alloy (SMA) wires was developed. The process chain for the actuator, starting from nickel-titanium wires manufactured into the actuator geometry by laser welding and thermo-mechanical treatment for the shape setting process up to the functionality evaluation of the actuator system, was implemented on a laboratory scale. The new revision procedure is based on a phase transformation of the SMA wire actuator, which was obtained through two methods—applying an electrical current by an instrument and rinsing the wire with heated water. The phase transformation of the actuator resulted in a contraction between 3.2% and 4.3% compared to its length after pre-stretching and was able to release the ceramic inlay from the cup. Therefore, the developed actuator design and process chain is a proof of concept towards a new revision procedure for modular acetabular cups. Full article
(This article belongs to the Special Issue Novel and Advanced Technologies for Orthopaedic Implant)
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15 pages, 3549 KiB  
Article
Genetic and Modifiable Risk Factors for Postoperative Complications of Total Joint Arthroplasty: A Genome-Wide Association and Mendelian Randomization Study
by Sijia Guo, Jiping Zhang, Huiwu Li, Cheng-Kung Cheng and Jingwei Zhang
Bioengineering 2024, 11(8), 797; https://doi.org/10.3390/bioengineering11080797 - 7 Aug 2024
Cited by 1 | Viewed by 1754
Abstract
Background: Total joint arthroplasty (TJA) is an orthopedic procedure commonly used to treat damaged joints. Despite the efficacy of TJA, postoperative complications, including aseptic prosthesis loosening and infections, are common. Moreover, the effects of individual genetic susceptibility and modifiable risk factors on [...] Read more.
Background: Total joint arthroplasty (TJA) is an orthopedic procedure commonly used to treat damaged joints. Despite the efficacy of TJA, postoperative complications, including aseptic prosthesis loosening and infections, are common. Moreover, the effects of individual genetic susceptibility and modifiable risk factors on these complications are unclear. This study analyzed these effects to enhance patient prognosis and postoperative management. Methods: We conducted an extensive genome-wide association study (GWAS) and Mendelian randomization (MR) study using UK Biobank data. The cohort included 2964 patients with mechanical complications post-TJA, 957 with periprosthetic joint infection (PJI), and a control group of 398,708 individuals. Genetic loci associated with postoperative complications were identified by a GWAS analysis, and the causal relationships of 11 modifiable risk factors with complications were assessed using MR. Results: The GWAS analysis identified nine loci associated with post-TJA complications. Two loci near the PPP1R3B and RBM26 genes were significantly linked to mechanical complications and PJI, respectively. The MR analysis demonstrated that body mass index was positively associated with the risk of mechanical complications (odds ratio [OR]: 1.42; p < 0.001). Higher educational attainment was associated with a decreased risk of mechanical complications (OR: 0.55; p < 0.001) and PJI (OR: 0.43; p = 0.001). Type 2 diabetes was suggestively associated with mechanical complications (OR, 1.18, p = 0.02), and hypertension was suggestively associated with PJI (OR, 1.41, p = 0.008). Other lifestyle factors, including smoking and alcohol consumption, were not causally related to postoperative complications. Conclusions: The genetic loci near PPP1R3B and RBM26 influenced the risk of post-TJA mechanical complications and infections, respectively. The effects of genetic and modifiable risk factors, including body mass index and educational attainment, underscore the need to perform personalized preoperative assessments and the postoperative management of surgical patients. These results indicate that integrating genetic screening and lifestyle interventions into patient care can improve the outcomes of TJA and patient quality of life. Full article
(This article belongs to the Special Issue Novel and Advanced Technologies for Orthopaedic Implant)
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19 pages, 2977 KiB  
Article
Debulking of the Femoral Stem in a Primary Total Hip Joint Replacement: A Novel Method to Reduce Stress Shielding
by Gulshan Sunavala-Dossabhoy, Brent M. Saba and Kevin J. McCarthy
Bioengineering 2024, 11(4), 393; https://doi.org/10.3390/bioengineering11040393 - 18 Apr 2024
Cited by 1 | Viewed by 2197
Abstract
In current-generation designs of total primary hip joint replacement, the prostheses are fabricated from alloys. The modulus of elasticity of the alloy is substantially higher than that of the surrounding bone. This discrepancy plays a role in a phenomenon known as stress shielding, [...] Read more.
In current-generation designs of total primary hip joint replacement, the prostheses are fabricated from alloys. The modulus of elasticity of the alloy is substantially higher than that of the surrounding bone. This discrepancy plays a role in a phenomenon known as stress shielding, in which the bone bears a reduced proportion of the applied load. Stress shielding has been implicated in aseptic loosening of the implant which, in turn, results in reduction in the in vivo life of the implant. Rigid implants shield surrounding bone from mechanical loading, and the reduction in skeletal stress necessary to maintain bone mass and density results in accelerated bone loss, the forerunner to implant loosening. Femoral stems of various geometries and surface modifications, materials and material distributions, and porous structures have been investigated to achieve mechanical properties of stems closer to those of bone to mitigate stress shielding. For improved load transfer from implant to femur, the proposed study investigated a strategic debulking effort to impart controlled flexibility while retaining sufficient strength and endurance properties. Using an iterative design process, debulked configurations based on an internal skeletal truss framework were evaluated using finite element analysis. The implant models analyzed were solid; hollow, with a proximal hollowed stem; FB-2A, with thin, curved trusses extending from the central spine; and FB-3B and FB-3C, with thick, flat trusses extending from the central spine in a balanced-truss and a hemi-truss configuration, respectively. As outlined in the International Organization for Standardization (ISO) 7206 standards, implants were offset in natural femur for evaluation of load distribution or potted in testing cylinders for fatigue testing. The commonality across all debulked designs was the minimization of proximal stress shielding compared to conventional solid implants. Stem topography can influence performance, and the truss implants with or without the calcar collar were evaluated. Load sharing was equally effective irrespective of the collar; however, the collar was critical to reducing the stresses in the implant. Whether bonded directly to bone or cemented in the femur, the truss stem was effective at limiting stress shielding. However, a localized increase in maximum principal stress at the proximal lateral junction could adversely affect cement integrity. The controlled accommodation of deformation of the implant wall contributes to the load sharing capability of the truss implant, and for a superior biomechanical performance, the collared stem should be implanted in interference fit. Considering the results of all implant designs, the truss implant model FB-3C was the best model. Full article
(This article belongs to the Special Issue Novel and Advanced Technologies for Orthopaedic Implant)
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