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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring Synthetic Organic Chemistry to Combat Pathogenic Infections

edited by

Cătălin Araniciu

Ioana Ionuț

and

Gabriel Marc

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: synthetic organic chemistry; antimicrobial agents; structure– activity relationship (SAR); drug design; molecular docking; drug discovery

(This special issue belongs to the Section Novel Antimicrobial Agents)

Multidrug-Resistant Microorganisms: Overcoming the Challenges in Antibiotic Treatment

edited by Eleni E. Mylona and

Dimitris Kounatidis

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: multidrug-resistant; antibiotic treatment; MDR pathogens; therapeutic strategies

Antibiotics and Environment—Research and Development Toward the One Health Approach, 2nd Edition

edited by

Takashi Azuma

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: antimicrobial resistance (AMR); antimicrobials; water purification plant (WTP); wastewater treatment plant (WWTP); hospital wastewater; livestock environment; aquaculture farm environment; aquatic environment

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Healthcare-Associated Infections (HAIs): Prevention, Control and Surveillance, 2nd Edition

edited by

Maria Bagattini

submission deadline 30 Apr 2026 | Viewed by 36 | Submission Open

Keywords: healthcare-associated infections (HAIs); infection prevention and control; antimicrobial resistance; HAIs management and control; carbapenem resistant (CR) Enterobacterales; carbapenem resistant (CR) Acinetobacter baumannii

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Resistance and Infections in Animals

edited by

John B. Kaneene

submission deadline 10 May 2026 | 6 articles | Viewed by 17400 | Submission Open

Keywords: antimicrobial resistance; mechanisms; humane and societal concerns; risk factors

(This special issue belongs to the Section Antibiotics in Animal Health)

Evidence-Based Pharmaceutical Care and Rational Antibiotic Use

edited by

Suodi Zhai

and Siyan Zhan

submission deadline 20 May 2026 | Viewed by 33 | Submission Open

Keywords: rational antibiotic use; bacterial resistance; medical institutions; optimization of antibiotic usage and dosages; prescription

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antibiotic Prescribing in Primary Dental Care—2nd Edition

edited by

Kristina Peros

submission deadline 30 May 2026 | Viewed by 140 | Submission Open

Keywords: primary dental care; antibiotic prescribing; rational drug prescribing; antibiotic stewardship

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Innovative and Translational Antibiosis Approaches to Tackling Protozoan Parasites: Synergy, Drug Repurposing, Natural Products, Molecular Targets, and Therapeutic Design

edited by

Leonardo Acuña

submission deadline 30 May 2026 | Viewed by 123 | Submission Open

Keywords: drug repurposing for neglected tropical diseases; natural products with antiparasitic activity; synergistic drug combinations; molecular targets and mechanisms of action

Antimicrobial Stewardship in Neonatal Intensive Care

edited by Chiara Poggi

submission deadline 30 May 2026 | Viewed by 45 | Submission Open

Keywords: neonatal sepsis; early onset sepsis; late onset sepsis; preterm; antimicrobial stewardship; neonatal intensive care; molecular diagnosis; stopping rule; therapeutic drug monitoring; extended antimicrobial infusion; continuous antimicrobial infusion; microbiological surveillance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Emerging Topics in Clostridioides difficile Infection: A One Health Problem

edited by

Simon D. Baines

submission deadline 31 May 2026 | 3 articles | Viewed by 6849 | Submission Open

Keywords: clostridium difficile infection (CDI); antimicrobial resistance (AMR); antimicrobial prescribing; one health; laboratory studies

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Optimizing Antimicrobial Therapy in NICU Settings: Strategies and Implications

edited by

Elias Iosifidis

and

Angeliki Kontou

submission deadline 31 May 2026 | 2 articles | Viewed by 3520 | Submission Open

Keywords: neonatal ICU; antimicrobial stewardship; antimicrobial resistance; neonatal sepsis; biomarkers

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Fungal Metabolites and Synthetic Derivatives: Antimicrobial Properties Toward Microbial Pathogens

edited by

João Vicente Braga De Souza

submission deadline 31 May 2026 | 2 articles | Viewed by 2638 | Submission Open

Keywords: antimicrobial resistance; fungal metabolites; synthetic derivatives; antifungal agents; bioactive compounds

(This special issue belongs to the Section Fungi and Their Metabolites)

Periprosthetic Joint Infection: Understanding the Epidemiology, Pathogenesis, Diagnosis and Treatment Options

edited by Saad Tarabichi, Mark J. Spangehl and Joshua S. Bingham

submission deadline 31 May 2026 | 2 articles | Viewed by 2134 | Submission Open

Keywords: periprosthetic joint infection; diagnosis; epidemiology; pathogenesis; treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Bioactives from Invertebrates

edited by

Beatriz Vázquez Belda

submission deadline 31 May 2026 | 1 articles | Viewed by 1913 | Submission Open

Keywords: invertebrates; bioactive compounds; antimicrobials; antibacterial activity; marine invertebrates; insects; worms; crustaceans; mollusks

(This special issue belongs to the Section Novel Antimicrobial Agents)

Molecular Epidemiology and Antibiotic Resistance in MRSA: Recent Advances in Surveillance and Control

edited by

Jae-Seok Kim

submission deadline 31 May 2026 | 1 articles | Viewed by 928 | Submission Open

Keywords: Staphylococcus aureus; methicillin-resistant S. aureus (MRSA); hospital-associated MRSA (HA-MRSA); antimicrobial resistance; molecular epidemiology; evolution of resistance; surveillance

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Genomic Surveillance of Antimicrobial Resistance (AMR)

edited by Linzy Elton

submission deadline 31 May 2026 | Viewed by 455 | Submission Open

Keywords: antimicrobial resistance; sequencing; genomics; surveillance; mobile genetic elements; multi-drug-resistant organisms; One Health; metagenomics; whole-genome sequencing

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Resistance and Intervention Strategies in Intestinal Pathogens: A One Health Approach

edited by Gaetano Iaquinto

submission deadline 31 May 2026 | Viewed by 145 | Submission Open

Keywords: epidemiology; antimicrobial resistance; multi-drug resistance; immunomodulatory activity; cytokines; gut microbiota; new antibiotics research; new vaccines; faecal microbiota transplantation; infection prevention

Rethinking Mild Infections: The Role of Natural Products in Antimicrobial Stewardship

edited by

Karel Kostev

submission deadline 31 May 2026 | Viewed by 135 | Submission Open

Keywords: natural products; herbal products; phytopharmaceutical; antimicrobial resistance; respiratory tract infections; urinary tract infections

Antimicrobial Nanomaterials: Advances, Challenges, and Future Perspectives

edited by

Nuno Miguel Figueiredo

and Daniela Santo

submission deadline 31 May 2026 | Viewed by 80 | Submission Open

Keywords: antimicrobial nanomaterials; metal and metal oxide nanoparticles and nanocomposites; carbon-based nanomaterials; polymeric and hybrid nanostructures; photocatalytic nanomaterials; multifunctional antimicrobial coatings; antimicrobial mechanisms of action; biocompatibility and toxicity

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Antimicrobial Resistance in Animals and Animal Products and Its Environmental Transmission Aspects, Second Edition

edited by

Nikolaos Solomakos

Thomai Lazou

and

Andreana Pexara

submission deadline 31 May 2026 | Viewed by 68 | Submission Open

Keywords: antimicrobial resistance; One Health; AMR dissemination in the environment; antibiotics in animals; foodborne pathogens; animal products

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Therapeutics for Bone and Periprosthetic Joint Infection, 2nd Edition

edited by

Éric M. Senneville

submission deadline 31 May 2026 | Viewed by 42 | Submission Open

Keywords: osteomyelitis; diabetic foot osteomyelitis; periprosthetic joint infections; antimicrobial therapy; recurrence; persistence; biofilm

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antibiotic Resistance Genes: Mechanisms, Evolution and Dissemination

edited by

Ivo Nikolaev Sirakov

and

Slawomir Ciesielski

submission deadline 31 May 2026 | Viewed by 38 | Submission Open

Keywords: antibiotic resistance genes; transposons; integrons; gene transfer; therapy

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Peptides (AMPs) Against Human Pathogens

edited by

Pedro Souza

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: antimicrobial peptides (AMPs); mechanisms; structure– function relationships; synthetic and bioengineered peptides

(This special issue belongs to the Section Antimicrobial Peptides)

The Antimicrobial Activity of Metal-Based Nanoparticles

edited by Suzan Pantaroto de Vasconcellos

submission deadline 10 Jun 2026 | 1 articles | Viewed by 1396 | Submission Open

Keywords: metal-nanoparticle; microbicide; virucide; phytopathogens; disinfectant; synthesis; antibiotic resistance

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Diagnostics, Antibiotic Usage and Surgery Related Techniques in Prevention and Treatment of Prosthetic Joint and Implant Related Infections

edited by

Bernd Fink

and

Steffen Ruchholtz

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3831 | Submission Open

Keywords: periprosthetic joint infection; implant-related infection; antibiotics; spacer; diagnosis; septic revision arthroplasty; irrigation; debridement

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

New Drugs, Innovative Antimicrobial Approaches, and Optimized Dosages: Bridging Research and Clinical Practice

edited by

Jerónimo Pachón

, Rocío Álvarez-Marín and

María E. Pachón-Ibáñez

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1660 | Submission Open

Keywords: antibiotics; antivirals; pharmacokinetics and pharmacodynamics; clinical evaluation; experimental studies; new antimicrobial approaches

Recent Developments in Antimicrobial Resistance Epidemiology and Antimicrobial Therapy for Clinically Relevant Bacteria

edited by

Georgios Meletis

submission deadline 30 Jun 2026 | Viewed by 199 | Submission Open

Keywords: antimicrobial resistance mechanisms; antimicrobial resistance detection; antimicrobial resistance epidemiology; antimicrobial treatment; MDR; Klebsiella pneumoniae; Acinetobacter baumannii; Pseudomonas aeruginosa; MRSA; VRE

Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology, 2nd Edition

edited by

Theodoros Karampatakis

and

Katerina Tsergouli

submission deadline 30 Jun 2026 | Viewed by 142 | Submission Open

Keywords: Gram-negative bacteria; virulence factors; antimicrobial resistance; molecular epidemiology; Klebsiella pneumoniae; Pseudomonas aeruginosa; Acinetobacter baumannii

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

New Approaches to the Treatment and Prevention of Fungal Infections

edited by

Célia Fortuna Rodrigues

submission deadline 30 Jun 2026 | Viewed by 105 | Submission Open

Keywords: biofilms; AMR; antifungals; infections; alternative treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antibiotic Utilization and Resistance Patterns in Perioperative and Surgical Settings

edited by Massimo Sartelli

submission deadline 30 Jun 2026 | Viewed by 73 | Submission Open

Keywords: antimicrobial resistance; surgical antibiotic prophylaxis; antibiotic therapy

Antimicrobial Agents Targeting Biofilms

edited by

Domenico Schillaci

submission deadline 30 Jun 2026 | Viewed by 60 | Submission Open

Keywords: biofim associated infections; virulence factors; antibiofilm agents

Marine-Derived Antibiotics

edited by

Ines Mancini

and

Andrea Defant

submission deadline 30 Jun 2026 | Viewed by 44 | Submission Open

Keywords: marine natural products; structural characterization; improved production of bioactive secondary metabolites; organic synthesis; structure– activity relationship (SAR); pathogen bacteria inhibition; antibiofilm activity; computational analysis; drug discovery; drug delivery systems

(This special issue belongs to the Section Novel Antimicrobial Agents)

Gram-Positive Cocci: Antimicrobial Resistance, Treatment, Susceptibility, and New Therapeutic Options

edited by

Felipe Piedade Gonçalves Neves

submission deadline 30 Jul 2026 | Viewed by 277 | Submission Open

Keywords: Streptococcus spp.; Enterococcus spp.; Staphylococcus spp.; antimicrobial resistance; molecular epidemiology; new therapeutic options

Antimicrobial Resistance: Epidemiology and Implications for Veterinary Medicine

edited by

Bruno de Araujo Penna

and

Eliane De Oliveira Ferreira

submission deadline 31 Jul 2026 | 4 articles | Viewed by 4337 | Submission Open

Keywords: antimicrobial resistance; One Health; epidemiology; transmission; zoonoses

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Resistance and One Health: New Solutions for an Old Problem?

edited by

David Rodríguez-Lázaro

and

José María Eiros-Bouza

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3920 | Submission Open

Keywords: antimicrobial resistance; one health; global health; surveillance; primary porduction; food safety; environment health; nosocomial infections

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Secondary Metabolites from Natural Sources: Mechanisms of Antimicrobial Action and Therapeutic Potential

edited by

Fatima Cerqueira

and

Maria Pia Ferraz

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2516 | Submission Open

Keywords: secondary metabolites; bioactive compounds

(This special issue belongs to the Section Plant-Derived Antibiotics)

A Public Health Lens on Antibiotic Use: From Prescription to Resistance for ENT Infections

edited by

Palmira Immordino

and

Angelo Immordino

submission deadline 31 Jul 2026 | Viewed by 614 | Submission Open

Keywords: antibiotic resistance; ENT infections; public health; prescribing practices; overuse of antibiotics; diagnostic stewardship; patient education; otolaryngology; infection control

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Pharmacist-Led Management of Antimicrobial Treatment

edited by

Doris Rušić

and Lovre Zekan

submission deadline 31 Jul 2026 | Viewed by 134 | Submission Open

Keywords: antimicrobial stewardship; community pharmacy; antibiotic resistance; antimicrobial use optimisation; pharmacist intervention; antibiotic prescribing; infectious diseases

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

From Nature to Laboratory Advances in Bioinspired Antimicrobial Drug Discovery

edited by

Cesar Augusto Roque-Borda

submission deadline 31 Jul 2026 | Viewed by 34 | Submission Open

Keywords: bioinspired antimicrobials; natural compounds; antimicrobial peptides; phytochemicals; peptidomimetics; hybrid conjugates; drug discovery; multidrug-resistant bacteria; controlled release; nanocarriers; structure– activity relationship; translational applications

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antimicrobial Properties of Essential Oils: Activities, Mechanisms, Applications, and Therapeutic Potential

edited by

Eduardo Valarezo

Miguel Ángel Meneses

and Matteo Radice

submission deadline 31 Aug 2026 | 1 articles | Viewed by 4103 | Submission Open

Keywords: antibiotics; antibacterial; antifungal; antiviral; ethnopharmacology; multidrug resistance; natural products; resistant strains; volatile secondary metabolites; volatile compounds

(This special issue belongs to the Section Plant-Derived Antibiotics)

Multi-Drug Resistant Gram-Negative Infections: Molecular Epidemiology, Microbiological Diagnosis, and Antimicrobial Treatment, 2nd Edition

edited by

Paolo Gaibani

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1340 | Submission Open

Keywords: pharmacodynamics/pharmacokinetics (PK/PD); enterobacterales; carbapenemase; novel molecules; antimicrobial resistance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Advances in Antimicrobial Action and Resistance

edited by

Manuel Simões

Jordi Vila

and

Nicholas Dixon

submission deadline 31 Aug 2026 | Viewed by 234 | Submission Open

Keywords: resistance; antibiotics; antimicrobials; one health; ethnopharmacology; stewardship; antimicrobial discovery; antimicrobial therapy; antimicrobial research

Antimicrobial Resistance and One Health: Environmental Health, Food Safety, and Practice of Health Professionals

edited by

Teresa Letra Mateus

and

Francisco Cortez Nunes

submission deadline 30 Sep 2026 | Viewed by 112 | Submission Open

Keywords: antibiotics; antibiotic resistance; guidelines compliance; health communication; One Health; public awareness

Epidemiology and Treatment of Microbial Infections in Respiratory Diseases

edited by

Marija Vukoja

and

Peđa Kovačević

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2041 | Submission Open

Keywords: pulmonary infections; respiratory diseases; epidemiology; treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Properties of Natural Substances: Alternatives for Managing Microbial Contamination

edited by

Bojana Danilović

and

Ivana Karabegović

submission deadline 31 Oct 2026 | Viewed by 159 | Submission Open

Keywords: antimicrobial activity; microbial contamination; essential oils; plant extracts

(This special issue belongs to the Section Plant-Derived Antibiotics)

Advances in Streptococcus spp. Research: Pathogenicity, Resistance, and Clinical Implications

edited by

Prescilla Emy Nagao

and

Louisy Sanches Dos Santos

submission deadline 30 Nov 2026 | Viewed by 168 | Submission Open

Keywords: Streptococcus; Corynebacterium; epidemiology; virulence; antimicrobial resistance

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antibiotics and Antibiotic Resistance Genes in the Environment: Transmission, Fate and Mitigation Strategies

edited by

Yongzhen Ding

Zulin Zhang

and

Hui Lin

submission deadline 31 Dec 2026 | Viewed by 75 | Submission Open

Keywords: antibiotic resistance genes (ARGs); veterinary antibiotic; manure and soil amendment; horizontal gene transfer; one health; environmental impact assessment; biodegradation and bioremediation; antimicrobial stewardship in agriculture; emerging contaminants

Silent but Deadly: Insights into the Relationship Between Bacterial Dormancy and Antibiotic Tolerance

edited by

Massimiliano Lucidi

submission deadline 31 Dec 2026 | Viewed by 17 | Submission Open

Keywords: antibiotic persistence; antibiotic tolerance; viable but not culturable bacteria; bacterial quiescence; phenotypic heterogeneity; stress-induced dormancy; recalcitrant infection; recurrent infection; relapsing infection

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

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