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Antibiotics
Special Issues
Periodontal Bacteria and Periodontitis: Infections and Therapy
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Periodontal Bacteria and Periodontitis: Infections and Therapy

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 2585

Special Issue Editor

Dr. Anna Skurska

E-Mail Website
Guest Editor
Department of Integrated Dentistry, Medical University of Bialystok, 15-276 Bialystok, Poland
Interests: periodontology

Special Issue Information

Dear Colleagues,

Periodontitis is a progressive and destructive inflammatory disease that affects the teeth supporting tissues. Its complex ethiology takes into account the interaction between subgingival microflora, the body's immune response and environmental factors. Bacterial biofilm is considered the main etiological factor causing gingivitis and leading to the destruction of periodontal tissues. Periopathogens in the subgingival area triggers defense mechanisms associated with the production of inflammatory factors and increased amounts of gingival crevicular fluid. As a result of inflammation and increased expression of proinflammatory cytokines, periodontal tissues are destroyed. Due to the infectious nature of the disease, treatment of periodontitis focuses largely on eliminating bacteria from the oral cavity. This Special Issue seeks manuscripts dealing with periodontal disease, espacially those dealing with its infection nature and therapy, antibiofilm strategies and means that can improve the therapeutic effect. Both original research and review articles are welcome.

Dr. Anna Skurska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontitis
  • infection
  • antibiotics
  • antibacterial activities

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Published Papers (3 papers)

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Research

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18 pages, 902 KB  
Article
The Influence of Local Antibiotic Therapy on the Microbiological, Clinical, and Radiological Outcomes Following Minimally Invasive Periodontal Surgery in the Treatment of Intrabony Defects—A Randomized Clinical Trial
by Anna Skurska, Amelia Baczewska, Robert Milewski, Piotr Majewski and Radosław Charkiewicz
Antibiotics 2025, 14(9), 850; https://doi.org/10.3390/antibiotics14090850 - 22 Aug 2025
Viewed by 599
Abstract
Objectives: Comparison of clinical, radiological, and microbiological outcomes following periodontal regeneration procedures with or without local antibiotic therapy. Methods: Forty patients, each presenting with a single vertical defect, were randomly assigned to either the test (SRP+ANB+MIST/M-MIST) or the control group (SRP+MIST/M-MIST). [...] Read more.
Objectives: Comparison of clinical, radiological, and microbiological outcomes following periodontal regeneration procedures with or without local antibiotic therapy. Methods: Forty patients, each presenting with a single vertical defect, were randomly assigned to either the test (SRP+ANB+MIST/M-MIST) or the control group (SRP+MIST/M-MIST). The periodontal regenerative procedures were carried out according to the general minimally invasive surgical technique principles, and the vertical bone defect was filled with an enamel matrix derivative (EMD—Emdogain®). Periodontal condition assessments were performed two weeks before the procedure, on the day of the surgical procedure, and at follow-up visit after 6 months. Radiographs were taken two weeks before, and 6 months after the surgery. To determine the microbiological profile of the surgical sites, subgingival plaque samples were collected for PCR analysis. Results: In both groups, a statistically significant pocket depth (PD) reduction and clinical attachment level (CAL) gain were observed over the 6-month follow-up period. The difference between the groups for PD and CAL parameters at 6 months was not statistically significant. Both groups showed a statistically significant reduction in the radiological depth and width of intrabony defects. Microbiological analysis revealed a statistically significant difference between the groups two weeks after subgingival antibiotic application for Fusobacterium nucleatum, Tannerella forsythia, and Prevotella intermedia. Conclusions: Periodontal tissue regeneration procedures according to minimally invasive principles (MIST/M-MIST) with the use of EMD lead to improvements in clinical and radiological parameters. Local antibiotic application results in a reduction in bacterial counts in short-term observations. Its use prior to regeneration procedures does not lead to additional improvements in clinical and radiological parameters. Full article
(This article belongs to the Special Issue Periodontal Bacteria and Periodontitis: Infections and Therapy)
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Review

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14 pages, 1308 KB  
Review
Antibiotics in Mucogingival Surgery for Recession Treatment: A Narrative Review
by Magdalena Latkowska-Wiśniewska, Sylwia Jakubowska and Bartłomiej Górski
Antibiotics 2025, 14(8), 769; https://doi.org/10.3390/antibiotics14080769 - 30 Jul 2025
Viewed by 858
Abstract
Gingival recession is a common problem, particularly affecting oral health and esthetics, and its treatment involves surgical root coverage procedures. The aim of this narrative review is to evaluate the role of systemic antibiotic therapy in mucogingival surgery for recession treatment. The available [...] Read more.
Gingival recession is a common problem, particularly affecting oral health and esthetics, and its treatment involves surgical root coverage procedures. The aim of this narrative review is to evaluate the role of systemic antibiotic therapy in mucogingival surgery for recession treatment. The available literature does not support routine antibiotic use in systemically healthy patients undergoing recession coverage surgery. Indications for prophylactic antibiotics are restricted to individuals at high risk of infective endocarditis and immunocompromised patients with elevated susceptibility to surgical site infections. Although mucogingival surgeries are performed in a non-sterile environment, the risk of infection remains low when proper aseptic techniques and good preoperative tissue preparation are applied. The review emphasizes the importance of making clinical decisions that consider the patient’s health status and are aligned with current recommendations. It also emphasizes the necessity for prospective studies to evaluate antibiotics’ effect on recession coverage procedures outcome. To bridge the gap between contemporary evidence and clinical practice and to foster responsible use of antibiotics in periodontal plastic surgery, the authors of this review integrate current evidence and clinical guidelines into a practical tool designed to assist clinicians in making reasoned, evidence-based decisions. Full article
(This article belongs to the Special Issue Periodontal Bacteria and Periodontitis: Infections and Therapy)
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13 pages, 590 KB  
Review
Potential Shifts in the Oral Microbiome Induced by Bariatric Surgery—A Scoping Review
by Zuzanna Ślebioda, Hélène Rangé, Marta Strózik-Wieczorek and Marzena Liliana Wyganowska
Antibiotics 2025, 14(7), 695; https://doi.org/10.3390/antibiotics14070695 - 10 Jul 2025
Cited by 1 | Viewed by 809
Abstract
Background: The oral microbiome differs in obese patients compared to normal-weight subjects. Microbiologic shifts very often appear after surgical interventions such as bariatric surgery (BS) and in immunocompromised patients. However, the oral microbiome composition and load in subjects after bariatric surgery are [...] Read more.
Background: The oral microbiome differs in obese patients compared to normal-weight subjects. Microbiologic shifts very often appear after surgical interventions such as bariatric surgery (BS) and in immunocompromised patients. However, the oral microbiome composition and load in subjects after bariatric surgery are unclear. Aim: The aim of this review is to summarize the current state of the art related to the oral microbiome shift induced by bariatric surgery and to discuss its implications on oral cavity health. Methods: Electronic databases: PubMed/Medline, Web of Science, and Cochrane Library were searched for articles published up to March 30, 2025, describing prospective studies focused on changes in the oral microbiota of patients who underwent bariatric surgery. Results: Eight studies measuring the oral microbiome with different approaches—16S ribosomal RNA (16S rRNA) sequencing, polymerase chain reaction (PCR), culture, and matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI TOF MS)—were included in this review. The following bariatric techniques were used: sleeve gastrectomy, Roux-en-Y gastric bypass, Omega loop gastric bypass, and laparoscopic gastric plication. The follow-up period ranged from 3 to 12 months. The results of microbiologic studies were unequivocal. There was an increment in Streptococcus mutans reported, high levels of Candida species, and increased rates of some periodontitis-associated bacteria (Porphyromonas gingivalis) in the post-bariatric surgery period, though some studies suggested a shift towards non-pathogenic composition of the oral microbiome in prospective observations. Conclusions: The local oral microbial homeostasis becomes strongly impacted by the bariatric surgical treatment itself as well as its consequences in the further post-operative period. Therefore, obese patients undergoing BS require very careful dental observation. Full article
(This article belongs to the Special Issue Periodontal Bacteria and Periodontitis: Infections and Therapy)
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