1 November 2026
Infections represent a major public health concern in sub-Saharan Africa, particularly in settings with high HIV prevalence and limited diagnostic capacity. In Gabon, epidemiological data on herpesvirus infections remain fragmented, making it difficu...
Background: Obesity-related inflammation and bacterial virulence may contribute to recurrent urinary tract infection (UTI). Examining inflammatory markers, host genetic variation and bacterial characteristics together may help clarify their associati...
Leprosy remains a significant public health challenge in endemic regions, where delayed diagnosis leads to irreversible nerve damage, disability, and ongoing transmission. To address the need for innovative diagnostic strategies, artificial intellige...
Traditional dairy products play an important role in both local family economies and human nutrition in Algeria. This research focused on isolating lactic acid bacteria (LAB) from traditional Algerian Lben samples prepared from a blended raw milk mat...
Antimicrobial resistance (AMR) is a rapidly escalating global health crisis, and multidrug-resistant (MDR) bacterial pathogens cause substantial morbidity, mortality, and economic burden. Conventional antibiotic-discovery pipelines remain slow, costl...
Background: Due to its growing resistance to treatment, dermatophytosis remains a major global health challenge. Recent case reports of tinea unguium resolution using low-dose food-grade hydrogen peroxide (FGHP) in two patients with 25- and 52-year h...
Antimicrobial resistance (AMR) is a major global health threat that erodes the effectiveness of antibiotics and increases morbidity, mortality, and healthcare costs. Updated forecasts project that bacterial AMR could directly cause approximately 39 m...
Background: TTIs remain a major threat to transfusion safety. This study assessed the association between ABO/Rh blood groups and HBV, HIV, HCV, and syphilis among 4.038 apparently healthy blood donors. Methods: A retrospective cross-sectional study...
Bovine tuberculosis (bTB) remains endemic in Morocco, where a national control strategy is implemented through screening and culling of infected animals. In this study, seven Mycobacterium bovis (M. bovis) strains were analyzed. Three strains were is...
Human papillomavirus (HPV) remains the principal etiological agent of cervical cancer, accounting for more than 95% of cases worldwide. Although the carcinogenic role of high-risk genotypes such as HPV-16 and HPV-18 has been extensively established,...
Viral encephalitis is a severe neurological condition in which direct viral injury and dysregulated neuroimmune responses jointly determine disease progression and long-term outcomes. Microglia are central to this process, supporting antiviral defens...
Background: Invasive pneumococcal disease (IPD) is predominantly caused by Streptococcus pneumoniae and is associated with high mortality. This vaccine-preventable disease has been a significant public health concern, particularly among children <...
Introduction: Ventilator-associated pneumonia (VAP) is associated with increased morbidity and mortality. Early-onset (EOVAP) and late-onset (LOVAP) VAP differ in risk factors, microbiology, and outcomes. Methods: A retrospective cohort study of adul...
The rising prevalence of multidrug-resistant (MDR) Enterobacterales poses a major challenge for the empirical treatment of urinary tract infections (UTIs). We evaluated the in vitro activity of mecillinam against urinary Escherichia coli and Klebsiel...
Carbapenem-resistant Enterobacterales (CRE) are a major public health concern, yet genomic data from Bulgaria remain limited. We investigated the genomic epidemiology and genomic characteristics of clinically significant CRE recovered at University H...
Background/Objectives: The identification of novel therapeutic targets is imperative to overcome the limitations of current anti-toxoplasmosis treatments. This study aims to investigate the potential of repurposing Pentamidine as an inhibitor against...
Antimicrobial resistance (AMR) is usually addressed through surveillance, prescribing policy, stewardship programs, infection prevention, and drug development. Less attention is given to an earlier educational question: how future doctors first learn...
Background: Refractory cytomegalovirus (CMV) infection remains a major challenge after solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT). Maribavir has demonstrated efficacy and a favorable safety profile in clinica...
Neonatal sepsis remains a leading cause of morbidity and mortality in the first month of life, yet its presentation is nonspecific, and its microbiological confirmation is uniquely difficult. Low-circulating bacterial loads, small obtainable blood vo...
Cryptococcus neoformans and Cryptococcus gatti are the two most common pathogenic species of the encapsulated yeast genus Cryptococcus and have been linked to fatal neurologic infections in both immunocompromised and healthy individuals. Cryptococcos...
Tuberculosis (TB) continues to be a significant public health challenge in Europe, despite a sustained decline in disease incidence over recent decades. This narrative review briefly traces the historical development of TB diagnosis and focuses on th...
Biofilm formation by Staphylococcus aureus presents a large challenge in clinical settings, as it confers resistance to antibiotics. Therefore, anti-biofilm agents that do not exert bactericidal effects are sought after. Extracts of cultivated Flammu...
LL-37 has attracted significant research attention as a multifunctional antimicrobial peptide which is implicated in a broad spectrum of activities. It is the only human cathelicidin and represents a key molecule in host defense. Hence, it is describ...
Leptospirosis remains a significant public health concern in the Philippines, particularly in urban tropical settings where environmental and climatic conditions favor disease transmission. This study examined temporal trends and factors associated w...
Background/Objectives: Antimicrobial resistance (AMR) is a major global health threat that has outpaced the development of new antibiotics. Drug repurposing has emerged as a promising strategy for identifying alternative antimicrobial therapies. Anti...
Neurosurgical devices provide clinical benefits that are undermined by the incidence of device-related infections. This study examined the microbiological and clinical characteristics of central nervous system (CNS) infections associated with cerebro...
Waterborne, water-related, and foodborne infectious diseases remain preventable causes of mortality, but long-term evidence on their demographic, spatial, and premature mortality burden is limited in Costa Rica. This ecological population-based study...
Plant-derived antimicrobials can potentially counteract the increasing ineffectiveness of conventional antibiotics against multidrug-resistant (MDR) ESKAPE pathogens. This study compared the extraction yield, phytochemical profile, functional-group s...
This study aimed to investigate the marked increase in blaNDM-1-positive Acinetobacter baumannii isolates (20% of all CRAB isolates) observed in a tertiary-care hospital in Central Greece during 2025. Thirty blaNDM-1-producing carbapenem-resistant A....
Street food is a fundamental part of the diet for millions of people, especially in Mexico, standing out for its accessibility, cost, and connection to culinary culture. Street food represents a practical alternative for the population and economic b...
Leptospirosis is among the most widespread zoonotic infections globally and is particularly prevalent in tropical settings, where it remains endemic. In Malaysia, the disease burden has increased markedly over recent decades. Severe leptospirosis can...
Effective reprocessing of surgical instruments is essential to prevent healthcare-associated infections in the field of veterinary medicine. However, chemical disinfectants are frequently used as alternatives to sterilization in small animal clinics,...
Antimicrobial resistance in companion animals is a growing public health concern, yet data on last-resort resistance genes in clinical canine isolates remain scarce. This study characterizes the molecular distribution of critical resistance determina...
Background: The clinical significance of Helicobacter pylori (H. pylori) infection in acute non-variceal upper gastrointestinal bleeding (NVUGIB) remains uncertain, particularly regarding short-term outcomes beyond rebleeding. Methods: We conducted a...
Background: The vagina undergoes important changes across the life course that are shaped not only by hormonal transitions but also by shifts in the vaginal microbial environment. Despite growing interest in the vaginal microbiome, research has dispr...
Introduction: In recent years, antibiotic resistance has increased a lot due to inappropriate prescribing practices, presenting a critical global health challenge. There is evidence of inappropriate prescription practices by dental practitioners in S...
Early-onset infection caused by Streptococcus agalactiae (Group B Streptococcus, GBS) may occur during gestation or delivery and can lead to severe neonatal sepsis, meningitis, or pneumonia. Discordant GBS infections in twin gestations are rare. We r...
Leptospirosis is a zoonotic disease caused by spirochetes of the genus Leptospira, primarily transmitted via direct or indirect contact with contaminated rodent urine. Human disease ranges from a mild, flu-like illness to severe, life-threatening Wei...
People living with HIV (PLWH) receiving effective antiretroviral therapy (ART) continue to exhibit chronic immune activation and systemic inflammation despite virological suppression. The viral envelope glycoprotein gp120, which binds the CD4 recepto...
Clostridioides difficile infection (CDI) remains a major cause of healthcare-associated morbidity and mortality, particularly among older adults and patients with recent healthcare exposure, underscoring the need for early risk stratification and acc...
The COVID-19 pandemic necessitated rigorous infection control protocols across hospital environments, particularly in nutrition services. UV-C light emerged as a viable option due to its shortest wavelength, conferring the greatest capacity for nucle...
Chlamydia is the most common sexually transmitted infection (STI) worldwide. In 2020, the global prevalence was estimated to be 4.0% among women and 2.5% among men aged 15 to 49 years. In more than 80% of cases, the infection is asymptomatic, thereby...
Parvovirus B19 is a DNA virus. Most parvoviruses infect animals; Parvovirus B19 infects humans. Parvovirus B19 is mainly transmitted through respiratory droplets during close contact, but additional routes such as transmission through contaminated bl...
The Institutional Review Board Statement and Informed Consent Statement sections in the original publication [...]
Genitourinary infections caused by Candida spp. and other yeasts have increased in incidence, and the emergence of resistant isolates to commonly prescribed antifungals is becoming more frequent. Thus, the purpose of this study was to characterize th...
The emergence and dissemination of antimicrobial resistance (AMR) are driven by complex, interconnected mechanisms involving microbial communities, environmental factors, and human activities, with climate change playing a pivotal and accelerating ro...
The European catfish (Silurus glanis, Linnaeus 1758), commonly known as the wels catfish, is one of the largest freshwater fish in Europe and an ecologically and economically important species in both natural ecosystems and aquaculture. Its broad nat...
Malassezia spp. has been recognized among neonatal intensive care unit (NICU) patients’ commensals and pathogens, accounting for a significant number of invasive fungal infections. The Random Amplified Polymorphic DNA (RAPD) may be used for Mal...
Linezolid (LZD) is an oxazolidinone antibiotic effective in the treatment of infection with Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The decline in susceptibility to linezolid is a concern for antimicrobia...
West Nile Virus (WNV), a mosquito-borne flavivirus first identified in Uganda in 1937, has emerged over the past quarter century as a major global public health threat. Since its introduction into North America in 1999, WNV has become the leading cau...
