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Breaking the Vicious Cycle? A Systematic Review of Interventions Targeting Both Falls and Fear of Falling in Older Adults -
Influence of Age on the Effectiveness of Lee Silverman Voice Treatment® BIG in Patients with Parkinson’s Disease: A Retrospective Exploratory Observational Study -
Knowledge, Attitudes, and Practices of Oral Care for Residential Older People Among Healthcare Providers in Macao -
Frailty Predicts Neurological Outcome in Chronic Subdural Hematoma: A Single-Center Prospective Cohort Study -
Association Between the Color Kanji Pick-Out Test App Performance and Cognitive Frailty as a Potential Early Screening Marker for Cognitive Decline
Journal Description
Geriatrics
Geriatrics
is an international, peer-reviewed, scientific open access journal on geriatric medicine published bimonthly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, ESCI (Web of Science), PubMed, PMC, and other databases.
- Journal Rank: CiteScore - Q2 (Health (Social Science))
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 27.7 days after submission; acceptance to publication is undertaken in 3.6 days (median values for papers published in this journal in the first half of 2026).
- Recognition of Reviewers: Reviewers whose reports are timely and of high quality receive an APC discount voucher for a future publication in an MDPI journal. Become a reviewer.
- Journal Cluster of Healthcare Sciences and Services: Geriatrics, Journal of Ageing and Longevity, Healthcare, Hospitals, Nursing Reports, Women, Journal of Gerontology and Geriatrics and Primary and Hospital Care.
Impact Factor:
2.4 (2025);
5-Year Impact Factor:
2.7 (2025)
Latest Articles
Sociodemographic Inequalities in Healthy Food Consumption Markers Among Older Adults Receiving Primary Health Care in Roraima, Brazil
Geriatrics 2026, 11(5), 132; https://doi.org/10.3390/geriatrics11050132 - 15 Sep 2026
Abstract
Background/Objectives: Noncommunicable diseases represent a major public health challenge, particularly among older adults. In this context, a healthy diet plays a key role in the prevention and management of these conditions. However, evidence on the associations between sociodemographic characteristics and previous-day food
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Background/Objectives: Noncommunicable diseases represent a major public health challenge, particularly among older adults. In this context, a healthy diet plays a key role in the prevention and management of these conditions. However, evidence on the associations between sociodemographic characteristics and previous-day food consumption markers among older adults remains limited. This study aimed to evaluate the association between sociodemographic factors and healthy food consumption markers among older adults in Roraima, Brazil. Methods: This cross-sectional study included 1322 older adults previously diagnosed with COVID-19 in the state of Roraima, Brazil. Sociodemographic information was obtained from electronic health records within the statewide Primary Health Care network. Healthy food consumption was assessed using the Food Consumption Markers Form from Brazil’s Food and Nutrition Surveillance System (Sistema de Vigilância Alimentar e Nutricional [SISVAN]). Multivariable Poisson regression models were fitted to examine potential associations. Results: Male participants had a lower prevalence of consuming fresh fruit + beans and fresh fruit + vegetables. Older adults who self-identified as Brown (pardo) had a higher prevalence of consuming fresh fruit + vegetables than those who self-identified as Yellow. Participants residing in the state capital showed a higher prevalence of consuming fresh fruit + beans, fresh fruit + vegetables, beans + vegetables, and all three food groups combined. Conclusions: Sociodemographic factors were associated with both individual and combined consumption of fresh fruit, beans, and vegetables among older adults in Roraima, Brazil.
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(This article belongs to the Topic Lifestyle, Health and Mental Well-Being Across the Lifespan)
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Open AccessArticle
Food Insecurity, Physical Activity, and Psychological Factors as Predictors of Life Satisfaction in Older Adults
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Mónica Lorena Hernández-Trujillo, Wilter C. Morales-García and Mardel Morales-García
Geriatrics 2026, 11(5), 131; https://doi.org/10.3390/geriatrics11050131 - 14 Sep 2026
Abstract
Background: Life satisfaction is a key component of subjective well-being in later life and may be associated with psychological, economic, family, functional, and food-related factors. Objective: This study aimed to identify factors associated with life satisfaction among older adults, considering sociodemographic characteristics, food
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Background: Life satisfaction is a key component of subjective well-being in later life and may be associated with psychological, economic, family, functional, and food-related factors. Objective: This study aimed to identify factors associated with life satisfaction among older adults, considering sociodemographic characteristics, food insecurity, physical activity, and psychological factors. Methods: A quantitative, observational, analytical, cross-sectional study was conducted with 200 noninstitutionalized older adults from Sogamoso, Colombia. Self-report instruments assessed life satisfaction, food insecurity, physical activity, depression, anxiety, and perceived stress. Data were analyzed using descriptive statistics, group comparison tests, Pearson correlations, and multiple linear regression. Results: Higher perceived stress (B = −0.762, p < 0.001), perceived insufficient income (B = −3.380, p < 0.001), self-employment (B = −2.153, p = 0.009), other sources of income (B = −2.569, p = 0.017), and technical education (B = −4.744, p = 0.003) were associated with lower life satisfaction. Conversely, combined engagement in strength and flexibility exercises (B = 3.203, p < 0.001), having two children (B = 3.498, p = 0.002), and having three or more children (B = 2.618, p = 0.008) were associated with higher life satisfaction. Primary education was not significantly associated with life satisfaction after adjustment (p = 0.093). Food insecurity was associated with life satisfaction in the bivariate analysis but did not remain statistically significant in the adjusted model. The regression model explained 48.7% of the variance in life satisfaction (R2 = 0.487; adjusted R2 = 0.457). Conclusions: Life satisfaction among older adults was associated with psychological, economic, family, and functional factors. The findings highlight the relevance of perceived stress, economic security, functional physical activity, and family resources when addressing subjective well-being in later life.
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Open AccessArticle
Prediction Model for Discharge Destination in Older Patients After Hip Fracture Surgery Using Early Predictors
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Sanne M. Krakers, Dieuwke van Dartel, Marloes Vermeer, Miriam M. R. Vollenbroek-Hutten and Johannes H. Hegeman
Geriatrics 2026, 11(5), 130; https://doi.org/10.3390/geriatrics11050130 - 11 Sep 2026
Abstract
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Objectives: To identify early predictors of discharge destination in patients aged ≥70 years following hip fracture surgery, using the Dutch Hip Fracture Audit (DHFA) Indicator Taskforce database with the aim of developing and validating a prediction model. Methods: Patients living in
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Objectives: To identify early predictors of discharge destination in patients aged ≥70 years following hip fracture surgery, using the Dutch Hip Fracture Audit (DHFA) Indicator Taskforce database with the aim of developing and validating a prediction model. Methods: Patients living in a (residential) home prior to the hip fracture were categorized into three discharge groups: home (n = 1322), geriatric rehabilitation (n = 2181), and nursing home (n = 337). The dataset was randomly split into a training set (75%) and a test set (25%). Potential predictors of discharge destination were collected immediately after hip fracture surgery and first tested univariately in the training set. Variables showing p < 0.15 were entered into a multinomial regression model. The model was validated on the test set. Results: The training set consisted of 2878 patients (median age: 83 years (IQR 77–89 years), 2012 females (70%)). The final multinomial regression model included age, gender, PFMS, premorbid Katz-ADL, ASA score, polypharmacy, history of dementia, delirium during previous hospital admissions, fall in the past six months, surgical treatment, anaesthesia type, and co-treatment by a geriatrician. The strength and direction of the associations between these variables and discharge destination varied across the three pairwise comparisons. The validated model predicted discharge to geriatric rehabilitation, home, and a nursing home with sensitivities of 86.7%, 37.9%, and 9.6%, respectively. Precision ranged from 33.3% (nursing home) to 60.9% (home) and 66.7% (geriatric rehabilitation). Conclusions: Discharge destination could be predicted with relatively high sensitivity and moderate precision for geriatric rehabilitation, whereas sensitivity and precision for predicting discharge home and to a nursing home remained limited. This highlights the need to refine the model before clinical implementation can be considered.
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Open AccessArticle
Shared Experiences with Caregiving for Loved Ones Living with Dementia in an Adult Day Health and Resource Center: A Thematic Analysis
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Michelle D. Hand, Megumi Inoue, Li-Mei Chen, Naoru Koizumi, Emma Booker, Sarah Nosrat, Samreen Mehak and Eyesha Shaikh
Geriatrics 2026, 11(5), 129; https://doi.org/10.3390/geriatrics11050129 - 10 Sep 2026
Abstract
Background: Slowing the progression of dementia and maintaining mental and social health and well-being are important aspects of health and healthcare for people living with dementia (PLwD). Relationships with family caregivers and unique caregiver insights are also important aspects of the health and
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Background: Slowing the progression of dementia and maintaining mental and social health and well-being are important aspects of health and healthcare for people living with dementia (PLwD). Relationships with family caregivers and unique caregiver insights are also important aspects of the health and well-being of PLwD. Methods: A group-based gaming system was developed to promote health and well-being for PLwD through movement, cognitive exercises, and social interaction. Included were family caregivers of clients living with mild- or moderate-stage impairment in an adult day center selected for the gaming intervention. Prior to implementing the intervention, three separate focus groups were conducted with 21 caregivers of PLwD, divided into each of the three focus groups based on their availability, to explore what it is like to care for someone living with dementia, their loved ones’ mood, and their questions or concerns regarding the gaming intervention. Responses were thematically analyzed. Results: In total, 21 caregivers participated in the focus groups. Six themes were identified: mutuality and strategies for coping with varying emotions; new challenges and successes with connecting and relating; multidimensional challenges with adjusting to decline, help-seeking, and providing care; community, social support, and resilience; technology and community resources as tools to ease caregiving burdens, and interest in digital gaming for PLwD. Conclusions: Our results suggest that group-based digital gaming interventions may be useful to both caregivers and PLwD, by offering meaningful opportunities for social engagement.
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(This article belongs to the Special Issue Care, Connection and Equity: Advancing the Science of Caregiving in Aging)
Open AccessCase Report
Burning Questions: Oral Ulceration Secondary to Improper Bisphosphonate Administration in Advanced Dementia
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Kate Murphy, Eleanor Marks, Kieran O’Connor and Elizabeth Moloney
Geriatrics 2026, 11(5), 128; https://doi.org/10.3390/geriatrics11050128 - 8 Sep 2026
Abstract
Background: Oral bisphosphonates are first-line osteoporosis therapy but can cause mucosal chemical injury when tablets are retained rather than swallowed correctly. This risk is heightened in cognitively impaired older adults with dysphagia or difficulty complying with medication administration guidelines. Case Presentation: A 73-year-old
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Background: Oral bisphosphonates are first-line osteoporosis therapy but can cause mucosal chemical injury when tablets are retained rather than swallowed correctly. This risk is heightened in cognitively impaired older adults with dysphagia or difficulty complying with medication administration guidelines. Case Presentation: A 73-year-old female nursing home resident with advanced vascular dementia presented with 24 h of oral pain, reduced intake, lethargy and new facial swelling. She had received monthly ibandronic acid 150 mg for two years, with documented difficulty swallowing tablets but no formal swallowing assessment. Examination showed ulceration of the left lower lip and anterior tongue with mild vestibular swelling. Clinical investigations excluded haematinic deficiency and osteonecrosis; traumatic, lichenoid, vesiculobullous and neoplastic causes were considered unlikely based on distribution, clinical features and temporal association with the recent dose. Bisphosphonate-associated chemical mucosal injury was diagnosed by hospital dental services. Ibandronic acid was discontinued, topical treatment initiated, and ulcers resolved by three weeks. Denosumab was substituted in view of the patient’s dysphagia and cognitive status. Discussion: This case supports the existing literature identifying inappropriate administration—often linked to dysphagia or physical impairment—as a leading cause of oral bisphosphonate-associated ulceration, typically affecting the tongue and lower lip. Ibandronate-related cases are rarely reported, likely reflecting prescribing frequency rather than lower risk. Current guidelines lack explicit recommendations addressing dysphagia or cognition in prescribing decisions. Conclusions: Presence of dysphagia and cognitive status should be assessed before and during oral bisphosphonate therapy. New oral pain, ulceration or facial swelling should prompt oral examination and medication review, with alternative antiresorptive agents considered when oral administration is impaired.
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(This article belongs to the Special Issue Oral Health Care in Older Adults)
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Open AccessArticle
Depression and Risk of Delirium in Older Adults: A Retrospective Cohort Study Using German Primary Care Data
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Christina Ryngler, Jens Bohlken, Nguyen Tien Huy and Karel Kostev
Geriatrics 2026, 11(5), 127; https://doi.org/10.3390/geriatrics11050127 - 8 Sep 2026
Abstract
Background: Depression and delirium are common neuropsychiatric disorders in older adults. Although studies suggest an association between the two conditions, evidence regarding the long-term risk of delirium in older patients with depression in outpatient primary care remains limited. Objective: This study examined the
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Background: Depression and delirium are common neuropsychiatric disorders in older adults. Although studies suggest an association between the two conditions, evidence regarding the long-term risk of delirium in older patients with depression in outpatient primary care remains limited. Objective: This study examined the relationship between depression and delirium in individuals aged ≥65 years. Methods: This retrospective cohort study used data from the German IQVIA Disease Analyzer database. It included individuals aged ≥65 years who received their first diagnosis of depression between 2005 and 2023. Using propensity score matching, patients with depression were matched 1:1 with individuals without depression. The primary outcome was incident delirium (ICD-10: F05). Time-dependent Cox regression models were applied for up to ten years of follow-up. Results: After matching, the study population consisted of 203,888 individuals (mean age: 75.8 years; 66% female). The incidence of delirium was higher in patients with depression than in controls (2.0% vs. 1.3%). Depression was associated with an elevated risk of delirium within the first two years after diagnosis (HR 1.42; 95% CI 1.14–1.75) and between six and ten years (HR 1.48; 95% CI 1.05–2.11). No statistically significant association was observed between years 3 and 5. Incident dementia was also associated with delirium (HR 1.52; 95% CI 1.14–2.02). Conclusions: Among older adults receiving outpatient care, depression was associated with a higher rate of subsequently documented delirium. These results complement existing evidence from inpatient settings. Due to the observational nature of the study, causal inferences cannot be made. In a sensitivity analysis excluding individuals with dementia at baseline, the association remained statistically significant across all intervals (HR 1.74, 1.53, and 1.82 for 0–2, 3–5, and 6–10 years, respectively).
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(This article belongs to the Section Geriatric Psychiatry and Psychology)
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Open AccessReview
A Scoping Review of Integrated Care Models for Managing Depression in Older Adults
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Mia Haddad, Jittima Panyasarawut, Chaowalit Srisoem, Dennis Miezah and Ling Shi
Geriatrics 2026, 11(5), 126; https://doi.org/10.3390/geriatrics11050126 - 8 Sep 2026
Abstract
Background: Depression is a major health issue among older adults and is frequently accompanied by chronic physical conditions. Conventional care of depression in older adults is delivered through primary care settings and often fails to address the complex interactions between mental health, physical
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Background: Depression is a major health issue among older adults and is frequently accompanied by chronic physical conditions. Conventional care of depression in older adults is delivered through primary care settings and often fails to address the complex interactions between mental health, physical illness, and social determinants of health in this population. Integrated care models, characterized by coordinated, multidisciplinary, and patient-centered approaches, have emerged as a promising strategy for improving depression outcomes in late life. Objective: This scoping review aimed to characterize integrated care models for managing depression in older adults. The review examined the structure and implementation of these models and evaluated depression-related outcomes. Methods: A systematic literature search was conducted in PubMed and Google Scholar. Studies published in English between 2006 and February 2026 were considered. Eligible studies included randomized controlled trials (RCTs), cluster RCTs, and quasi-RCTs that evaluated integrated care interventions targeting depression in adults aged 65 years or older or mixed adult populations that included older adults. One reviewer conducted the search and initial screening, and four additional reviewers evaluated the eligibility of full-text reports and extracted data using a structured template. Results were synthesized descriptively. Results: Seventeen studies met the inclusion criteria. Integrated care interventions were implemented across primary care clinics, community health centers, and home healthcare programs in several countries. Participants commonly had depression alongside chronic medical conditions, including diabetes, hypertension, heart failure, or chronic obstructive pulmonary disease. Integrated care models varied in staffing, therapeutic components, specialist involvement, delivery intensity, and comparator conditions. Most interventions incorporated multidisciplinary care teams; structured symptom monitoring; care coordination; behavioral or psychological interventions; and, in some studies, chronic disease management, social support, or technology-supported follow-up. Thirteen studies reported a favorable depression-related finding at one or more assessment points; however, benefits were not always sustained, and some studies reported null- or comparator-favoring findings. Conclusions: Integrated care for depression in older adults encompasses heterogeneous models implemented across diverse healthcare contexts. Common themes included multidisciplinary collaboration, coordinated follow-up, structured psychological or behavioral treatment, symptom monitoring, and integration of mental and physical health management. Favorable outcomes were reported in most studies, but findings varied by population, setting, comparator, intervention intensity, and follow-up duration. These findings may inform future program design, although the effectiveness of the integrated care models and the independent contribution of individual components remain uncertain.
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(This article belongs to the Section Geriatric Public Health)
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Open AccessArticle
Views on Ageing and Loneliness in Older Patients Undergoing Geriatric Treatment
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Luise Umfermann, Aline Schönenberg and Tino Prell
Geriatrics 2026, 11(5), 125; https://doi.org/10.3390/geriatrics11050125 - 7 Sep 2026
Abstract
Background/Objectives: Loneliness is a clinically relevant psychosocial factor in later life and has been associated with adverse mental, cognitive, and physical health outcomes. Views on ageing may shape social engagement, coping, and perceived belonging, but evidence from geriatric patient populations remains limited.
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Background/Objectives: Loneliness is a clinically relevant psychosocial factor in later life and has been associated with adverse mental, cognitive, and physical health outcomes. Views on ageing may shape social engagement, coping, and perceived belonging, but evidence from geriatric patient populations remains limited. This study examined whether views on ageing are associated with loneliness in geriatric patients. Secondary analyses explored subjective age, including felt age and the perceived onset of old age. Methods: This cross-sectional analysis used baseline data from two prospective observational studies in geriatric patients (N = 459). Loneliness was assessed with the three-item UCLA Loneliness Scale. Views on ageing were measured using five items from the German Ageing Survey. Associations were examined using Spearman correlations, non-parametric group comparisons, and multiple linear regression. Results: Participants had a mean age of 83.1 years and 65.6% were female. The mean UCLA loneliness score was 1.54 ± 2.07, and the mean views on ageing sum score was 13.21 ± 2.72. More negative views on ageing were associated with higher loneliness (ρ = 0.122, p = 0.009). In the fully adjusted regression model, views on ageing remained independently associated with loneliness after adjustment for chronological age, sex, and depressive symptoms (β = 0.117, p = 0.014; adjusted R2 = 0.051). Depressive symptoms were also independently associated with loneliness (β = 0.182, p < 0.001), whereas chronological age and sex were not. At the item level, associations with loneliness were mainly driven by reduced positive ageing-related beliefs. Higher felt age was associated with higher loneliness (ρ = 0.151, p = 0.003), while a later perceived onset of old age was associated with lower loneliness (ρ = −0.136, p = 0.017). Conclusions: In geriatric patients, more negative views on ageing were weakly associated with higher loneliness independent of depressive symptoms. The small effect size suggests that views on ageing should be interpreted as one modest component within a broader biopsychosocial understanding of loneliness in geriatric care.
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(This article belongs to the Section Geriatric Psychiatry and Psychology)
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Coaching-Driven Digital Literacy for Older Adults: Results from AGAPE Ecosystem Pilot Study
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Matei Teodorescu, Chiara Pedrini, Ileana Ciobanu, Andreea Georgiana Marin, Emanuela Elena Mihai, Sabrina Tazzari, Maria Luigia del Vicario, Jensen Selwyn Joymangul, Ana Goreti Oliveira, Elena Tamburini, Francesco Agnoloni, Francesca Cecchi and Mihai Berteanu
Geriatrics 2026, 11(5), 124; https://doi.org/10.3390/geriatrics11050124 - 6 Sep 2026
Abstract
Introduction: Rapid technological development requires continuous learning and adaptation, yet many older adults (OAs) face difficulties using digital technologies. The AGAPE project (Active aGeing And Personalised service Ecosystem) aimed to promote active and healthy ageing (AHA) among adults aged 65+ by supporting independent
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Introduction: Rapid technological development requires continuous learning and adaptation, yet many older adults (OAs) face difficulties using digital technologies. The AGAPE project (Active aGeing And Personalised service Ecosystem) aimed to promote active and healthy ageing (AHA) among adults aged 65+ by supporting independent functioning reducing caregiver burden, and improving eHealth literacy through personalized, user-friendly digital services co-created and tested in Italy, Portugal, and Romania. Objective: AGAPE pilot phase evaluated the effectiveness and usability of innovation adoption strategies designed to improve technology acceptance, digital literacy, and behavioural change among older adults and caregivers. This study examined participants’ perceptions of digital technologies and self-reported digital efficacy during a multicomponent intervention combining repeated technology use, personalized coaching, digital literacy and health education, technical assistance, and support from informal and formal caregivers. Material and Methods: The multiple-sites uncontrolled pilot study combined home-based use of the AGAPE digital technologies with long-term combined personalized support. Data were collected at baseline (T0), intermediate (T1), and final (T2) assessments using the System Usability Scale (SUS), technostress questionnaire, digital adoption questionnaire (TAM-derived), EQ-5D-5L, CarerQoL-7D, and the UCLA Loneliness Scale, complemented by participant feedback, technology usage, and activity data. Results: The study included 217 participants, of whom 146 were OAs. Over the course of the intervention, participants showed reductions in technostress and improvements in perceived digital efficacy, although the magnitude and direction of change varied across pilot sites. The findings also indicated that contextual and social factors contributed to technology adoption and engagement. Conclusions: Participation in the multicomponent AGAPE intervention was associated with positive longitudinal changes in technology-related perceptions, technostress, and digital self-efficacy. The findings support the feasibility and potential of combining digital technologies with personalized coaching and broader interpersonal support to facilitate technology adoption among older adults. However, given the uncontrolled study design and the integrated nature of the intervention, the observed changes cannot be attributed independently to coaching or to any single intervention component.
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(This article belongs to the Special Issue Digital Health Equity: Bridging the Gap for Elderly People and People with Disabilities)
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Open AccessArticle
Association Between Subjective Symptoms, Psychological Stress and Quality of Life Among Older Japanese Adults
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Sachie Ono, Akira Komatsuzaki, Yukika Enoki, Takeshi Kamoda, Chikage Kato and Kiyoka Arashi
Geriatrics 2026, 11(5), 123; https://doi.org/10.3390/geriatrics11050123 - 4 Sep 2026
Abstract
Background/Objectives: A crucial issue in Japan, as a rapidly aging society, is supporting the quality of life (QOL) of older adults to ensure they do not require long-term care. This study aims to examine the association between subjective symptoms and psychological stress
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Background/Objectives: A crucial issue in Japan, as a rapidly aging society, is supporting the quality of life (QOL) of older adults to ensure they do not require long-term care. This study aims to examine the association between subjective symptoms and psychological stress and QOL decline using a large-scale Japanese national statistics database. Methods: Anonymized data were analyzed from 23,649 adults aged ≥ 65 years, obtained from the Comprehensive Survey of Living Conditions carried out in 2019 in Japan. The degree of association of different factors with QOL decline was analyzed using univariate symptom analysis and adjusted odds ratios (ORs) obtained through binary logistic regression. We also compared the reported frequency and mean number of symptoms in a group with poor QOL and one with good/regular QOL. Results: In the group with poor QOL, significantly more individuals were aged ≥ 75 years, had high levels of psychological stress (Kessler Psychological Distress Scale [K6]), and reported subjective symptoms (p < 0.01). The mean number of symptoms was significantly higher in this group (5.77) than in the good/regular QOL group (3.34, p < 0.01). In the binary logistic regression, the variables with the highest adjusted ORs were the K6 group (4.49), impaired limb movement (2.81), and numbness of the limbs (2.01). Conclusions: These findings indicate that different symptoms, including stress, have varying impacts on QOL in older adults. Addressing symptoms associated with reduced QOL in community-dwelling older adults may help promote continued aging in place.
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(This article belongs to the Section Geriatric Public Health)
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Open AccessSystematic Review
Specialized Delirium Care Environments in Hospitalized Older Adults: A Systematic Review
by
Henri Perrin, Giulio Mastria, Alberto Garcia Manjon and Patrizia D’Amelio
Geriatrics 2026, 11(5), 122; https://doi.org/10.3390/geriatrics11050122 - 4 Sep 2026
Abstract
Purpose: Delirium is a frequent and serious condition in older patients, associated with severe adverse outcomes and lacking proven pharmacological treatments. Non-pharmacological multicomponent strategies are recommended, and specialized delirium care environments (e.g., delirium room, delirium unit, psychogeriatric unit) have been proposed as a
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Purpose: Delirium is a frequent and serious condition in older patients, associated with severe adverse outcomes and lacking proven pharmacological treatments. Non-pharmacological multicomponent strategies are recommended, and specialized delirium care environments (e.g., delirium room, delirium unit, psychogeriatric unit) have been proposed as a potential strategy to improve the management of delirium in hospitalized older adults. Our objective was to provide the first systematic review and pooled analysis on the subject, synthesizing the characteristics of specialized delirium environments in the care of delirium and their association with clinical outcomes. Methods: A systematic search of MEDLINE, Cochrane, and EMBASE identified studies on patients aged 65 years and older with delirium or related acute confusional states admitted to specialized delirium care environments. Study quality was assessed using Cochrane’s risk of bias tools, and exploratory pooled analyses were conducted when at least three studies reported the same outcome. Results: Nine studies, reported across 15 publications and including 2226 patients, met the inclusion criteria. Interventions were heterogeneous in structure and content, but most combined delirium-oriented staff training, enhanced surveillance, environmental adaptation, and multicomponent non-pharmacological care. Comparator groups were also diverse and included standard wards, earlier versions of specialized care models, indirect admission pathways, and non-delirious controls. The narrative synthesis suggested that specialized delirium care environments were most consistently associated with shorter delirium duration, more favorable discharge outcomes, lower physical restraint use, and better functional recovery, while findings for length of stay, falls, psychotropic drug use, and mortality were less consistent. Exploratory pooled analyses suggested a favorable direction of effect for several outcomes, particularly discharge destination and mortality, but pooled estimates were not statistically significant and should not be interpreted as definitive evidence of efficacy. All included studies were judged to be at a high or critical risk of bias. Conclusions: Specialized delirium care environments appear promising for the management of delirium in hospitalized older adults, particularly for outcomes closely related to day-to-day delirium care. However, the current evidence base is limited by substantial heterogeneity in intervention models, comparator groups, and outcome definitions, as well as by a high risk of bias across studies. These findings support further evaluation of specialized delirium care models, but do not yet allow firm conclusions regarding their effectiveness.
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(This article belongs to the Section Geriatric Psychiatry and Psychology)
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Open AccessCase Report
Very Late-Onset Myasthenia Gravis in a Very Elderly Patient: Diagnostic Challenges and Importance of Early Recognition
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Nermina Polimac Gorana and Almedina Spiljak
Geriatrics 2026, 11(5), 121; https://doi.org/10.3390/geriatrics11050121 - 4 Sep 2026
Abstract
Background: Myasthenia gravis is an autoimmune disorder of the neuromuscular junction characterized by fluctuating skeletal muscle weakness. Late-onset MG (onset ≥ 50 and <65 years) and very late-onset MG (VLOMG; onset ≥ 65 years) are increasingly recognized subgroups, and diagnosis in very elderly
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Background: Myasthenia gravis is an autoimmune disorder of the neuromuscular junction characterized by fluctuating skeletal muscle weakness. Late-onset MG (onset ≥ 50 and <65 years) and very late-onset MG (VLOMG; onset ≥ 65 years) are increasingly recognized subgroups, and diagnosis in very elderly patients remains challenging because symptoms frequently overlap with age-related conditions and comorbidities. Case Presentation: An 88-year-old man with very late-onset myasthenia gravis (symptom onset at approximately age 85) was urgently referred because of a several-day history of rapidly worsening dysphagia and dysarthria, superimposed on fluctuating diplopia, dysphagia, dysarthria, and fatigable bulbar symptoms that had progressively worsened over the preceding three years. Initial diagnostic evaluation was challenging because of advanced age, previous lacunar infarctions, and multiple comorbidities, including pulmonary thromboembolism, chronic kidney disease, and permanent pacemaker implantation (which precluded brain MRI). Neurological examination and the characteristic fluctuation of symptoms raised suspicion of myasthenia gravis. Serological testing confirmed markedly elevated acetylcholine receptor antibodies, whereas MuSK antibodies were negative. Repetitive nerve stimulation was not performed given the high antibody titer and unambiguous clinical presentation. Thoracic computed tomography excluded thymoma. Treatment with pyridostigmine, azathioprine (maintenance dose kept lower than standard due to chronic kidney disease stage IIIB), and low-dose prednisone (selected due to age and comorbidity profile) resulted in early, patient-reported clinical improvement (approximately 60% in speech and swallowing) over eight weeks of follow-up; a validated severity scale (MG-ADL) showed a score of six (scoring range 0–24). Conclusions: Myasthenia gravis should remain an important differential diagnosis in very elderly patients presenting with fluctuating ocular and bulbar symptoms, even in the presence of multiple comorbidities that may obscure the diagnosis. In this patient, early recognition, antibody testing, and individualised initiation of therapy were followed by meaningful short-term improvement; a single case with eight weeks of follow-up cannot establish that such therapy prevents disease progression or myasthenic crisis, and longer follow-up and additional cases are needed.
Full article
(This article belongs to the Section Geriatric Neurology)
Open AccessReview
Behavioral Interventions to Increase Physical Activity Among Dementia Caregivers: A Narrative Review of Behavior Theory, Behavior Change Techniques, and Mechanisms of Behavior Change
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Ashley M. Goodwin, Alex Makhnevich, Karina W. Davidson, Liron Sinvani and Mark J. Butler
Geriatrics 2026, 11(5), 120; https://doi.org/10.3390/geriatrics11050120 - 3 Sep 2026
Abstract
Background: Due to the rise in Alzheimer disease (AD) and AD-related dementias (AD/ADRD) in an aging population, millions of caregivers will be at risk for physical and mental health decline. As those they care for already have physical and cognitive impairment, it is
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Background: Due to the rise in Alzheimer disease (AD) and AD-related dementias (AD/ADRD) in an aging population, millions of caregivers will be at risk for physical and mental health decline. As those they care for already have physical and cognitive impairment, it is crucial that caregivers maintain health-promoting behaviors. Because regular physical activity (PA) prevents functional loss and improves physical health and well-being, understanding how to help caregivers adopt and sustain PA despite unique time, caregiving, and self-efficacy barriers is a pressing public-health priority. Existing health-promoting interventions among dementia caregivers, including PA, have demonstrated limited success. To overcome the fragmentation and slow synthesis of behavioral science evidence, the Human Behavior-Change Project advocates theoretical grounding, systematic mapping of intervention components (e.g., behavior change techniques [BCTs]) using standardized taxonomies, and explicit specification of mechanisms of behavior change (MoBCs). Objective: To examine the limited success of health-promotion interventions among dementia caregivers we aimed to conduct a narrative review to synthesize evidence from interventions that evaluated PA in dementia caregivers across three domains: (1) use of behavioral theory to inform intervention design, (2) specification of BCTs, and (3) identification and measurement of MoBCs. Methods: Two scientific databases were searched to identify representative studies and reviews, using key terms including “physical activity”, “intervention”, “dementia”, and “caregiver” from inception to July 2025. Results: Seven primary intervention trials and six reviews were selected for inclusion. Gaps across the domains were identified to inform priority areas for future research. Conclusions: There is a need to develop tailored, theory-driven PA interventions that target empirically supported BCTs and MoBCs to improve dementia caregivers’ health and well-being.
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(This article belongs to the Special Issue Healthy Ageing and Lifestyle Medicine: Current Knowledge and Future Direction (2nd Edition))
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Long-Term Survival of Very Elderly Patients with Heart Failure Managed in a Comprehensive Heart Failure Management Unit
by
Sonia González-Sosa, Alba Rodríguez-Quintana, Pablo Santana-Vega, Jose A. Rodríguez-González, José M. García-Vallejo, Jorge Arencibia-Borrego and Alicia Conde-Martel
Geriatrics 2026, 11(5), 119; https://doi.org/10.3390/geriatrics11050119 - 3 Sep 2026
Abstract
Background: Heart failure (HF) is the leading cause of hospitalisation in older adults, with incidence increasing markedly with age. However, long-term outcome data in patients aged ≥85 years remain limited. We evaluated survival and predictors of mortality in this very elderly HF
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Background: Heart failure (HF) is the leading cause of hospitalisation in older adults, with incidence increasing markedly with age. However, long-term outcome data in patients aged ≥85 years remain limited. We evaluated survival and predictors of mortality in this very elderly HF population enrolled in a structured outpatient programme. Methods: A retrospective observational study was conducted, including patients aged ≥85 years assessed at a Comprehensive HF Management Unit between 2012–2023. Demographic characteristics, comorbidities, functional (Barthel) and cognitive (Pfeifer) status, laboratory parameters, hospitalisations, and survival status were collected. Long-term survival was estimated using the Kaplan–Meier method, and predictors of mortality were analysed using Cox regression models. Results: A total of 514 patients were included (mean age 88.4 ± 3 years, 46.1% male); 340 (66.1%) died during follow-up. Survival was 77% at 1 year, 50% at 2.5 years, and 25% at 5 years. Mortality was associated with diabetes (p = 0.038), advanced chronic kidney disease (p = 0.008), dementia (p < 0.001), neoplasia (p = 0.007), ischaemic heart disease (p < 0.001), history of HF (p = 0.043), NYHA III–IV (p < 0.001) and elevated NT-proBNP (p < 0.001). Worse functional and cognitive status, higher comorbidity according to the Charlson Comorbidity Index and readmission at one year (all p < 0.001) were also related to mortality. In the first multivariable model, worse cognitive and functional status, a higher Charlson comorbidity index, NYHA class III–IV, and high NT-proBNP were independent predictors of mortality. When 1-year HF readmission was added to the model, the Charlson index (HR:1.10; 95%CI 1.01–1.19), high NT-proBNP (HR:1.76; 95%CI 1.30–2.38) and HF readmissions within 1 year (HR:2.68; 95%CI 1.72–4.16) remained independently associated with mortality. Conclusions: In patients aged ≥85 years with HF, survival was poor, with only half alive at 2.5 years and 25% at 5 years. Comorbidity burden, high natriuretic peptides, and early readmission independently predicted mortality, underscoring the importance of comprehensive assessment in this population.
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(This article belongs to the Section Cardiogeriatrics)
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A Patient- and Function-Centric Model/Approach for Hypoglycemia Management in Older Adults
by
Kannayiram Alagiakrishnan, Laurie Mereu, Gulelala Rahim, Mahua Ghosh and Albert Vu
Geriatrics 2026, 11(5), 118; https://doi.org/10.3390/geriatrics11050118 - 3 Sep 2026
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Diabetes-related hypoglycemia contributes substantially to increased morbidity, mortality, health-care utilization, and reduced quality of life. Older adults with diabetes represent a heterogeneous group of patients who need individualized blood glucose targets to avoid hypoglycemia. Since the elderly present with varying degrees of functional
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Diabetes-related hypoglycemia contributes substantially to increased morbidity, mortality, health-care utilization, and reduced quality of life. Older adults with diabetes represent a heterogeneous group of patients who need individualized blood glucose targets to avoid hypoglycemia. Since the elderly present with varying degrees of functional and cognitive status and individualized health needs, their management varies among individuals. Complicating this, the hypoglycemia risk in older adults treated with insulin also varies due to aging, renal dysfunction, cognitive impairment, and other comorbidities. The challenge for healthcare providers is in considering all aspects of care in order to avoid hypoglycemia in elderly individuals. In this review, we introduce a Patient and Function Centric Approach to the assessment and management of hypoglycemia in older adults. This holistic framework extends beyond blood glucose values to systematically evaluate the other domains of patients’ health that influence hypoglycemia risk, including biochemical, medication, timing, autonomic, cognitive, mood, renal, pancreatic, hepatic, social, and physical function. The management of hypoglycemia in older adults should also include strategies to address both fear of hypoglycemia and hypoglycemia unawareness. In addition to physical limitations, the psychosocial barriers to self-care in older individuals with hypoglycemia are also of paramount importance. Using tools that measure diabetes burden, diabetes distress, and fear of hypoglycemia provides valuable insights into patient wellbeing. The use of newer anti-hyperglycemic medications, sensor-augmented insulin pump therapy, intranasal glucagon, and continuous glucose monitoring (CGM) has significantly contributed to reduced hypoglycemia incidence in individuals with diabetes. Overall, successful management requires a collaborative approach that empowers patients, respects their individual needs and preferences and helps them face the challenges associated with diabetes management with confidence rather than fear or anxiety. Adopting a patient- and function-centric approach to hypoglycemia management allows clinicians to move beyond a one-size-fits-all model and adopt individualized glycemic targets that improve overall diabetes control and mental well-being.
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Open AccessReview
Minimally Invasive Implant Rehabilitation in Geriatric Patients: A Comprehensive Narrative Review of Contemporary Strategies to Avoid Extensive Bone Augmentation Procedures
by
Angelo Aliberti, Wien Cirine Ben Amor, Mauro Mariniello, Gilberto Sammartino, Oreste Trosino and Francesco Giordano
Geriatrics 2026, 11(5), 117; https://doi.org/10.3390/geriatrics11050117 - 1 Sep 2026
Abstract
Background/Objectives: The management of edentulism and severe alveolar bone loss in older adults remains a significant challenge in implant dentistry. Given the potential biological and therapeutic burden associated with extensive regenerative procedures, increasing interest has been directed toward treatment strategies that utilize
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Background/Objectives: The management of edentulism and severe alveolar bone loss in older adults remains a significant challenge in implant dentistry. Given the potential biological and therapeutic burden associated with extensive regenerative procedures, increasing interest has been directed toward treatment strategies that utilize available anatomy and reduce surgical complexity. This narrative review examined contemporary augmentation-avoidance approaches for implant rehabilitation in geriatric patients. Methods: A structured narrative literature search was performed in PubMed/MEDLINE, Scopus, and Web of Science, including studies published up to 30 May 2026. Clinical studies, systematic, umbrella and narrative reviews, meta-analyses that evaluate augmentation-avoidance approaches in implant dentistry were considered. The review examined evidence relevant to older adults, including clinical, prosthetic, functional, and patient-centered outcomes. Results: The available literature describes multiple strategies for managing reduced bone availability, including short and ultra-short implants, narrow-diameter implants, tilted implant concepts, pterygoid and trans-sinus implants, zygomatic implants, immediate loading protocols, flapless and computer-guided surgery, and implant-retained overdentures. These approaches have broadened the range of treatment options available for patients with reduced bone availability and may reduce the need for extensive regenerative procedures in selected clinical situations. In addition to implant and prosthetic outcomes, increasing attention has been directed toward oral health-related quality of life, masticatory function, treatment satisfaction, and maintenance requirements. However, evidence specifically focused on geriatric populations remains limited. Conclusions: Contemporary implant dentistry offers several alternatives to extensive bone regeneration in carefully selected geriatric patients, although current evidence is largely extrapolated from mixed adult populations. Treatment planning should integrate anatomical conditions with systemic health, functional status, frailty-related factors, and long-term maintenance considerations. Further geriatric-focused research is needed to support patient-centered decision-making and optimize long-term rehabilitation outcomes in aging populations.
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(This article belongs to the Special Issue Oral Health Care in Older Adults)
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Translating Mortality Hazard Ratios into Remaining-Lifespan Measures in Older Adults Using Japanese Complete Life Tables: A Deterministic Reference-Table Study
by
Takashi Shibuya, Nobuo Kutsuna, Tomoya Ohida, Miwa Nakamura and Hanako Kinugasa
Geriatrics 2026, 11(5), 116; https://doi.org/10.3390/geriatrics11050116 - 31 Aug 2026
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Background/Objectives: Mortality hazard ratios (HRs) do not directly express remaining lifespan or fixed-time survival. We constructed Japanese age–sex–HR reference tables and examined uncertainty, time patterns, and age-based translation. Methods: Using the 23rd Complete Life Tables for Japan, 2020, we transformed annual death probabilities
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Background/Objectives: Mortality hazard ratios (HRs) do not directly express remaining lifespan or fixed-time survival. We constructed Japanese age–sex–HR reference tables and examined uncertainty, time patterns, and age-based translation. Methods: Using the 23rd Complete Life Tables for Japan, 2020, we transformed annual death probabilities at index ages of 65–90 years with HRs of 1.00–4.00. Outcomes were median remaining lifespan; mean remaining years; 1-, 3-, 5-, and 10-year survival; and a baseline-equivalent age shift obtained by matching each transformed median to the HR 1.00 median curve. Results: At the age of 75 years, the median remaining lifespans at HRs of 1.00, 1.50, 2.00, 2.50, and 4.00 were 12.6, 10.1, 8.4, 7.3, and 5.1 years in men and 16.8, 14.3, 12.6, 11.3, and 8.8 years in women. An HR of 2.00 corresponded to baseline-equivalent age shifts of 5.8 and 4.8 years. A hypothetical HR interval of 1.50–2.50 translated to median ranges of 7.3–10.1 and 11.3–14.3 years. Relative to an HR of 2.00 throughout, a one-year front-loaded HR of 4.00 followed by an HR of 2.00 reduced median lifespan by 0.42 and 0.19 years but reduced 5-year survival by 3.8 and 1.9 percentage points. Conclusions: Life tables provide reproducible translations of HRs. Applying an external HR requires proportionality and transportability assumptions; the outputs are not validated patient-specific prognoses.
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Prevalence of Sarcopenia and Factors Associated with Body Composition and Protein Intake in Institutionalized Older Adults from Three Long-Term Care Facilities in Loja, Ecuador: A Cross-Sectional Study
by
Ana Sofía Vivanco-Zárate, Mateo Julián Sánchez-Sánchez and Estefanía Bautista-Valarezo
Geriatrics 2026, 11(5), 115; https://doi.org/10.3390/geriatrics11050115 - 31 Aug 2026
Abstract
Background/Objectives: Sarcopenia is a common public health problem in older adults and is associated with an increased risk of morbidity and mortality, particularly in institutionalized populations. This study aimed to determine the prevalence of sarcopenia in institutionalized older adults, assess the adequacy of
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Background/Objectives: Sarcopenia is a common public health problem in older adults and is associated with an increased risk of morbidity and mortality, particularly in institutionalized populations. This study aimed to determine the prevalence of sarcopenia in institutionalized older adults, assess the adequacy of protein intake in terms of quantity and quality, and identify factors associated with its presence. Methods: An observational, analytical, cross-sectional study was conducted in three institutional care homes in Loja canton, Ecuador, between 2024 and 2025. A total of 44 older adults aged ≥65 years were included. Sarcopenia was diagnosed according to the EWGSOP2 criteria, and protein intake was assessed using the direct food-weighing method over three days. Descriptive, comparative, and binary logistic regression analyses were performed. Results: The prevalence of confirmed and severe sarcopenia was 61.3%. Severe sarcopenia was more frequent in men, whereas probable sarcopenia was more frequent in women. Participants with sarcopenia presented with lower skeletal muscle mass, skeletal muscle index, and muscle strength. Protein intake was generally insufficient compared with international recommendations, although protein quality was predominantly high or very high. Higher skeletal muscle mass and higher body mass index were independently associated with a lower likelihood of sarcopenia. Conclusions: Sarcopenia in institutionalized older adults appears to be more closely associated with body composition and overall nutritional status than with protein quantity or quality alone. These findings support a comprehensive approach to the prevention and management of sarcopenia that combines adequate nutrition with tailored physical exercise interventions.
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(This article belongs to the Special Issue Healthy Ageing and Lifestyle Medicine: Current Knowledge and Future Direction (2nd Edition))
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The Association of an Electronic Frailty Index with Glaucoma Shunt Outcomes
by
Neel Edupuganti, Richa Saxena and Atalie C. Thompson
Geriatrics 2026, 11(5), 114; https://doi.org/10.3390/geriatrics11050114 - 31 Aug 2026
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Background/Objectives: Recent studies have shown frailty to be a significant predictor of postoperative complications and mortality across multiple surgical fields. Older adults with glaucoma refractory to medical management often require drainage implantation to achieve intraocular pressure control, yet the impact of frailty
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Background/Objectives: Recent studies have shown frailty to be a significant predictor of postoperative complications and mortality across multiple surgical fields. Older adults with glaucoma refractory to medical management often require drainage implantation to achieve intraocular pressure control, yet the impact of frailty remains unstudied. This study evaluated the association of frailty status with glaucoma shunt success and postoperative complications. Methods: A retrospective single-center review was performed for older adults who underwent glaucoma drainage device implantation from January 2015 to July 2025. Included patients had a documented electronic frailty index (eFI) score and were followed for up to 1 year of follow-up. Partial surgical success was defined as an IOP of 5–21 mmHg with a ≥20% IOP reduction from baseline at 1 year; complete success additionally required absence of severe complications. Logistic regression assessed predictors of surgical success. Kaplan–Meier and Cox proportional hazards models evaluated time to postoperative complications. Results: Among 200 patients/eyes (mean age = 70.6 years), 60% were pre-frail or frail. At 1 year, 79% achieved partial success, and nearly two-thirds had no postoperative complications. Frail/pre-frail status was significantly associated with a higher risk of postoperative complications (HR = 1.90, 95% CI (1.07, 3.36), p = 0.027) though not with achieving partial success (OR = 1.49, 95% CI (0.72, 3.07)). There were no significant sociodemographic predictors of postoperative complication timing (all p > 0.05). Conclusions: Being pre-frail or frail meaningfully increased vulnerability to postoperative complications but was not associated with achieving partial or complete surgical success. The elevated complication risk highlights the importance of frailty assessment in preoperative planning for older adults. Future studies should evaluate how integrating frailty screening into perioperative discussions may optimize outcomes and support shared decision-making in aging patients undergoing glaucoma surgery.
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Novel Hypothesis on Phase Angle as a Candidate Marker Associated with Physiological Reserve in Geriatric Patients in Long-Term Care
by
Alejandro Padilla Isassi, Rosalba Maya Hernández, María Elisa Otero Cerdeira and Ingrid Alejandra Abarca Salinas
Geriatrics 2026, 11(5), 113; https://doi.org/10.3390/geriatrics11050113 - 25 Aug 2026
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Background: Physiological reserve reflects the capacity of the organism to maintain homeostasis under biological stress. We suggest the hypothesis that phase angle derived from bioelectrical impedance analysis could be a potential objective marker of Physiological reserve. Methods: An analytical cross-sectional study
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Background: Physiological reserve reflects the capacity of the organism to maintain homeostasis under biological stress. We suggest the hypothesis that phase angle derived from bioelectrical impedance analysis could be a potential objective marker of Physiological reserve. Methods: An analytical cross-sectional study was conducted in 45 older adults residing in long-term care units at Hospital Español de México (2025). Frailty was assessed with the FRAIL index, sarcopenia using EWGSOP2 criteria, functionality with the Barthel Index, and quality of life with WHOQOL-OLD. Body composition and phase angle were measured by multifrequency bioelectrical impedance (InBody BWA 2.0®). Associations were analyzed using ROC curves and regression models. Results: Phase angle (PA) was closely associated with key geriatric domains. Frail participants showed significantly lower PA values (3.1 ± 0.7 vs. 3.8 ± 0.9; p = 0.009), while sarcopenic patients presented lower PA (3.1 ± 0.7 vs. 4.1 ± 0.9; p < 0.001). PA demonstrated a strong positive correlation with functional status (r = 0.668; p < 0.001). A moderate positive correlation was observed with quality of life (r = 0.551; p = 0.001). In an exploratory multivariable analysis, PA was independently associated with age (B = −0.063; p < 0.001), functionality (B = 0.013; p < 0.001), and frailty (B = −0.137; p = 0.044). Conclusions: The phase angle is associated with key geriatric conditions that are related to reduced physiological reserves in older adults in long-term care, addressing the hypothesis that phase angle reflects physiological reserve at the cellular level by providing preliminary cross-sectional evidence.
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