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Gout, Urate, and Crystal Deposition Disease, Volume 4, Issue 3

2026 September - 6 articles

Cover Story: Millions of years ago, human ancestors lost functional uricase, allowing the accumulation of urate. This review explores the reason why this loss was adaptive: it elevated antioxidant capacity, enabled efficient fat storage during ancient feast-or-famine cycles, supported cognition, and primed immune defenses. In the often calorie-rich and hyper-palatable modern world, this same adaptation now fuels gout, hypertension, and metabolic disease, which represents the present-day price we pay for an ancient evolutionary trade-off that once facilitated our survival. View this paper
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Articles (6)

  • Article
  • Open Access
429 Views
12 Pages

A Randomized Controlled Trial Investigating the Impact of Disease Labels on the Public’s Perceptions About Calcium Pyrophosphate Deposition (CPPD) Disease

  • Vicky Tai,
  • Rachel Murdoch,
  • Keith J. Petrie,
  • Anne M. Horne and ,
  • Borislav Mihov,
  • Greg D. Gamble and
  • Nicola Dalbeth
  • + 2 authors+ 0 author

Background and Objectives: The nomenclature of calcium pyrophosphate deposition (CPPD) disease remains confusing, with different labels used interchangeably to describe the disease. Although ‘CPPD disease’ is the term that has been recomm...

  • Review
  • Open Access
899 Views
13 Pages

Humans and other great apes are unique among animals in lacking functional uricase, an enzyme that breaks down urate and allows its excretion. Modern-day humans have elevated serum urate, which is associated with various chronic health issues, includ...

  • Review
  • Open Access
1,578 Views
26 Pages

Gout in Southeast Asia: An Ancient Disease in a Region in Flux

  • Kanon Jatuworapruk,
  • Chinh Nghia Pham,
  • Syahrul Sazliyana Shaharir,
  • Panchalee Satpanich and ,
  • Nattawat Watcharajittanont and
  • Jose Paulo Lorenzo
  • + 1 author+ 0 author

Gout is one of the most common inflammatory arthritides worldwide, and its burden is rising in Southeast Asia alongside rapid demographic and socioeconomic transitions. This region, characterized by diverse healthcare systems, cultural practices, and...

  • Review
  • Open Access
1,162 Views
10 Pages

Urinary Alkalization Therapy in Primary Gout: A Narrative Review

  • Mingshu Sun,
  • Rui Wang,
  • Chuantao Wu,
  • Xianghong Meng and
  • Changgui Li

Gout is a systemic metabolic inflammatory disease driven by hyperuricemia and monosodium urate crystal deposition, and is frequently accompanied by chronic kidney disease and uric acid nephrolithiasis. Current evidence indicates that acidic urine, hy...

  • Brief Report
  • Open Access
432 Views
8 Pages

Background and Objectives: Despite evidence demonstrating the advantages of rheumatology-led point-of-care (POC) polarised light microscopy (PLM), it remains underutilised in many hospital settings. We aimed to identify barriers to its use and assess...

  • Article
  • Open Access
1,069 Views
11 Pages

Calcific Tendinitis Is Mainly Associated with Basic Calcium Phosphate Deposition, but Rare Cases of Calcium Pyrophosphate Can Occur

  • Jannes Anton Knop,
  • Andrea Schwab,
  • Nicole Märtens,
  • Christian Wybrandski and ,
  • Sina Stücker,
  • Agnieszka Halm-Pozniak,
  • Alexander Berth,
  • Christoph H. Lohmann and
  • Jessica Bertrand
  • + 4 authors+ 0 author

Calcific tendinitis (CT) is a condition that most commonly affects the rotator cuff tendons of the shoulder joint. Fundamental crystal morphology and composition underlying different radiological stages of CT remained insufficiently characterized. We...

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Gout Urate Cryst. Depos. Dis. - ISSN 2813-4583