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Muscles, Volume 5, Issue 2

2026 June - 24 articles

Cover Story: Progressive colitis in Winnie mice is associated with a systemic skeletal muscle phenotype. This study shows that as intestinal inflammation worsens, mice develop reduced muscle mass, smaller muscle fibers, lower oxidative capacity, and impaired voluntary wheel-running performance. These changes are most evident in the 15-week cohort and correlate with fecal inflammatory markers, supporting a link between gut inflammation and muscle impairment. The findings highlight the Winnie mouse as a clinically relevant model to study IBD-associated myopenia and the gut–muscle axis. View this paper
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Articles (24)

  • Article
  • Open Access
762 Views
20 Pages

19 June 2026

Hip joint position sense (JPS), a key component of neuromuscular function arising from muscle spindle and periarticular mechanoreceptor input, remains underexplored, with no standardized and reliable clinical protocol available to assess hip proprioc...

  • Article
  • Open Access
589 Views
13 Pages

15 June 2026

Micronutrients are essential for optimal muscle metabolic function. We previously showed that heat-induced skeletal muscle injury is associated with depletion of nicotinamide adenine dinucleotide (NAD+) and magnesium (Mg2+), and boosting NAD+ abundan...

  • Review
  • Open Access
1,899 Views
18 Pages

11 June 2026

The DMD gene is best known for its product dystrophin, a large rod-shaped protein that plays a critical role in muscular membrane strength and integrity. Mutations affecting dystrophin lead to Duchenne muscular dystrophy, a fatal X-linked disease cha...

  • Article
  • Open Access
785 Views
13 Pages

10 June 2026

Hemoglobin levels play an important role in oxygen delivery to skeletal muscle, and reduced levels may impair muscle function and contribute to sarcopenia, particularly in patients with cancer. The aim of the present study was to evaluate the influen...

  • Review
  • Open Access
1,155 Views
22 Pages

Structural and Functional Principles in Quadriceps Reconstruction

  • Andrei Cretu,
  • Eliza-Maria Bordeanu-Diaconescu,
  • Catalina-Stefania Dumitru,
  • Cristian-Vladimir Vancea and ,
  • Mihaela-Cristina Andrei,
  • Adriana Serban,
  • Cristian-Sorin Hariga,
  • Cristian-Radu Jecan,
  • Ioan Lascar and
  • Andreea Grosu-Bularda
  • + 5 authors+ 0 author

Quadriceps muscle and tendon injuries are a significant cause of impairment of the knee extensor mechanism, ranging from minor muscle strains to complete tendon ruptures and extensive defects following oncologic resections. This narrative review prov...

  • Article
  • Open Access
993 Views
21 Pages

Purpose: To develop a fully automated 2D nnU-Net pipeline for multi-class skeletal muscle segmentation (psoas, paraspinal, and abdominal wall) at the third lumbar (L3) vertebral level, and to quantitatively evaluate its diagnostic performance and rel...

  • Review
  • Open Access
1 Citations
1,703 Views
33 Pages

To maintain homeostatic conditions and optimal function during stressors, mitochondria initiate retrograde signaling. The mitochondrial integrated stress response (ISR) and unfolded protein response (UPRmt) are critical quality control mechanisms act...

  • Article
  • Open Access
1,133 Views
18 Pages

Progressive Myopenia and Functional Decline in the Winnie Mouse Model of Chronic Colitis

  • Shilpa Sharma,
  • Danielle Debruin,
  • Jeannie Devereaux,
  • Alan Hayes and ,
  • Kulmira Nurgali and
  • Gustavo Duque
  • + 1 author+ 0 author

Muscle wasting contributes substantially to inflammatory bowel disease (IBD)-related disability, but its association with colitis severity across disease stages remains poorly characterized. We therefore assessed skeletal muscle mass, fiber morpholog...

  • Article
  • Open Access
1,193 Views
14 Pages

Effect of an Arm-Span-Adjusted Hand Position on Closed Kinetic Chain Upper Extremity Stability Test Performance and Muscle-Related Body Composition Associations

  • Filippos Christodoulou,
  • Petros Maniatis,
  • Andreas Erotocritou,
  • Stelios Hadjisavvas and ,
  • Michalis A. Efstathiou,
  • Irene-Chrysovalanto Themistocleous and
  • Manos Stefanakis
  • + 2 authors+ 0 author

Background: The Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) is used to assess upper-extremity performance in a closed kinetic chain position. The standard hand placement of 36 inches may favor individuals with larger body dimensions...

  • Systematic Review
  • Open Access
2,130 Views
17 Pages

Background: Musculoskeletal pain remains a major cause of disability worldwide, encompassing disorders such as rheumatoid arthritis (RA), osteoarthritis (OA) and chronic back pain. Acupuncture and dry needling are increasingly used for symptom manage...

  • Review
  • Open Access
1,663 Views
23 Pages

Centronuclear myopathy (CNM) is a genetically heterogenous congenital myopathy traditionally classified as a membrane remodeling disorder. Emerging evidence reveals that centronuclear myopathy mutations converge upon common cellular dysfunction exten...

  • Article
  • Open Access
1,853 Views
14 Pages

Effects of Resistance Respiratory Training on Respiratory Muscle Strength in Healthy Active Individuals

  • Antonela Karmen Ivišić,
  • Dario Vrdoljak,
  • Nikola Foretić,
  • Vladimir Pavlinović and
  • Ivan Drviš

Background: Respiratory muscle strength (RMS) is a critical factor influencing athletic performance, particularly in high-intensity or prolonged activities. RMS encompasses inspiratory (IMs) and expiratory muscles (EMs), which differ in anatomical st...

(This article belongs to the Topic Endurance and Ultra-Endurance: Implications of Training, Recovery, Nutrition, and Technology on Performance and Health)
  • Article
  • Open Access
1,193 Views
11 Pages

Background/Objectives: Sarcopenia, characterized by progressive loss of skeletal muscle mass and function, is a major public health concern among aging populations. While physical activity is recognized as protective, the comparative effectiveness of...

  • Article
  • Open Access
1,685 Views
17 Pages

Open-Source Tools for Neuromuscular Electrical Stimulation in Mouse Models: A Methodological Validation Study

  • Bana H. Odeh,
  • Amanda L. Wellman,
  • Michael Ameye,
  • Zachary Atwood and ,
  • Luke Gray,
  • Aiswarya Saravanan,
  • Havish Poluru,
  • Morium Begam,
  • Takako I. Jones and
  • Joseph A. Roche
  • + 6 authors+ 1 author

30 April 2026

Neuromuscular electrical stimulation (NMES) is integral to studying muscle function in healthy and dystrophic mice. Certain commercial electrodes and laboratory stimulators used for NMES in mice are no longer in production. We developed and/or tested...

  • Article
  • Open Access
1,063 Views
14 Pages

30 April 2026

Stretching of the upper trapezius muscle reduces stiffness and choroidal blood flow velocity, but its effect on skin blood flow remains unclear. We evaluated the changes in upper trapezius skin circulation hemodynamics before/after self-stretching us...

  • Article
  • Open Access
1,206 Views
13 Pages

Respiratory Cycle Influence on Lumbosacral Muscle Function: A Tensiomyographic Analysis

  • Anthony B. Trombetta,
  • William J. Hanney,
  • Abigail W. Anderson and
  • Morey J. Kolber

28 April 2026

Background: Tensiomyography (TMG) offers a noninvasive means of evaluating skeletal muscle contractile properties, including muscle displacement (Dm), delay time (Td), contraction time (Tc), half-relaxation time (Tr), and sustain time (Ts). When appl...

  • Review
  • Open Access
1 Citations
5,142 Views
18 Pages

21 April 2026

Although widely used, massage has not been reported to be effective in enhancing recovery from exercise-induced muscle damage in humans. Studies using massage-like interventions in animal models have, in contrast, consistently demonstrated a signific...

  • Article
  • Open Access
1,410 Views
15 Pages

Investigation of Effects of Ultrasound Therapy on Trapezius Muscle Stiffness and Choroidal Blood Flow Velocity

  • Takanori Taniguchi,
  • Ryoutarou Mutou,
  • Kokoro Oki,
  • Miki Yoshimura and ,
  • Yuko Kodama,
  • Nao Nakamura and
  • Yuki Hashimoto
  • + 2 authors+ 0 author

21 April 2026

This study evaluated changes in upper trapezius muscle stiffness and choroidal blood flow velocity before and after ultrasonic therapy of the trapezius muscle. Participants included 27 healthy young adults in their 20 s (median age [Q1–Q3]: 21....

  • Review
  • Open Access
2 Citations
3,928 Views
13 Pages

Revisiting Myositis Ossificans: A Comprehensive Stage-by-Stage Imaging Review

  • Consolato Gullì,
  • Giuseppe Ferrara,
  • Emanuele Ferravante,
  • Roberto Calbi and ,
  • Mario Di Diego,
  • Davide Parisi,
  • Daniele Perla,
  • Tommaso Villa and
  • Luigi Natale
  • + 4 authors+ 0 author

14 April 2026

Myositis ossificans (MO) is a benign, self-limiting heterotopic ossification process that typically develops within soft tissues following trauma, although non-traumatic forms have also been described. Despite its benign nature, MO frequently represe...

  • Article
  • Open Access
1,308 Views
11 Pages

13 April 2026

Dynamic muscular endurance, the ability to lift a submaximal load until task failure, is a common measure in both cross-sectional and training studies. However, the repeatability of low-load muscular endurance in the knee extensors has not been well...

  • Review
  • Open Access
2,378 Views
28 Pages

30 March 2026

Physical exercise can influence cognitive performance and neurobiological processes, but evidence spans diverse modalities, intensities, and adult populations. Acute exercise represents a state of transient skeletal muscle activation that induces sys...

  • Article
  • Open Access
1 Citations
1,387 Views
15 Pages

25 March 2026

(1) Background: Handgrip strength (HGS) is a widely used indicator of neuromuscular function, with predictive values for health and performance outcomes. The aim of this study was to evaluate the intraday and interday reliability of maximal and explo...

  • Article
  • Open Access
1,005 Views
15 Pages

Estrogen Receptor Alpha (ERα) Is Involved in Resveratrol-Mediated Muscle Preservation During Mechanical Unloading in Male Rats

  • David Ayi-Bonte,
  • Samantha Dworacek,
  • James Madden,
  • Jacob Evans and ,
  • Ingrid E. Lofgren,
  • Kathleen J. Melanson,
  • Christie L. Ward-Ritacco and
  • Marie Mortreux
  • + 3 authors+ 0 author

25 March 2026

NASA intends to return humans to the Moon, where partial gravity will put them at risk of musculoskeletal deconditioning. Resveratrol (RSV) is a promising nutritional countermeasure that may protect muscle health during disuse; however, its efficacy...

  • Article
  • Open Access
1 Citations
1,461 Views
14 Pages

25 March 2026

Research has yet to investigate the effects of unilateral Nordic hamstring training with a sloped platform (UNHT) on the fascicle length of the biceps femoris long head (BFlh FL) in previously injured legs. This study aimed to address this gap. A lon...

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Muscles - ISSN 2813-0413