2026 September - 23 articles
Background: Duchenne muscular dystrophy (DMD) is the most common X-linked progressive neuromuscular disorder of childhood. The classic course of DMD is characterized by onset after a period of normal motor development. However, in recent years, evide...
Sprinters and jumpers differ in their force–velocity demands, so this exploratory study compared their acute countermovement jump (CMJ) response to isometric conditioning. Methods: Twenty-two competitive track and field athletes (10 sprinters,...
Background: Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition in physically active individuals. Although quadriceps strengthening has traditionally been the cornerstone of conservative management, hip-strengthening exercises h...
Residual muscles after amputation experience mechanical unloading, loss of distal tendon insertion, and reduced excursion, conditions known to cause muscle degeneration. However, the architecture of residual muscles following amputation remains large...
Background: Because falls can lead to loss of autonomy in individuals with post-tuberculosis lung disease (iwPTLD), assessing fall risk is crucial for reducing the likelihood of fractures and preventing the decline of physical function. This cross-se...
Background: In patients with peripheral arterial disease (PAD), the presence of sarcopenia is associated with increased morbidity and mortality. However, sarcopenia is widely underrecognized and scientifically scarcely researched in PAD. Thus, we aim...
High-intensity interval training (HIIT) is widely recognized as an effective strategy for improving cardiorespiratory fitness and metabolic health. Beyond these physiological benefits, growing evidence indicates that HIIT may also induce beneficial i...
This study compared elbow flexor hypertrophy and maximal strength adaptations after eight weeks of resistance training performed either to momentary muscular failure or with 1–3 repetitions in reserve (RIR). Nineteen resistance-trained adults c...
Primary dystrophin deficiency, caused by X-chromosome mutations within the DMD gene, encompasses a continuous clinical spectrum of neurological, muscular, and cardiac disorders known as dystrophinopathies that exhibit profound phenotypic variability...
Charcot–Marie–Tooth (CMT) is a rare, genetic, slowly progressive disorder that affects nerve conduction, particularly in the limbs and, therefore, the muscles. Phenotypes vary, but the impact on quality of life is always present. CMT1A is...
Myostatin (GDF8) is a member of the transforming growth factor-β (TGF-β) superfamily. Myostatin gene mutations or inhibition of the Myostatin/Activin pathway results in increased skeletal muscle mass, demonstrating its role as a negative re...
Background: Pathogenic variants in the DMD gene are a frequently overlooked cause of dilated cardiomyopathy (DCM) in idiopathic cases, especially when skeletal myopathy is mild or seemingly absent. Becker muscular dystrophy (BMD) and X-linked dilated...
Background: Sports-related musculoskeletal injuries, including tendon, ligament, muscle, and cartilage damage, often heal slowly and incompletely. Current treatments may not fully restore tissue function, necessitating regenerative therapies. Objecti...
Skeletal muscle dysfunction and exercise intolerance are major extrapulmonary manifestations of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), yet their severity is not fully predicted by pulmonary impairment. T...
Background: Skeletal muscle index (SMI, kg/m2) derived from bioelectrical impedance analysis (BIA) is widely used to assess muscle mass. However, SMI is influenced by extracellular fluid, potentially leading to inaccurate estimation in patients with...
High-intensity exercise performance is a complex phenomenon that emerges from the interaction of neuromuscular, metabolic, molecular, and biomechanical systems. While previous research has primarily examined these factors independently, a comprehensi...
Nutrient supplementation may enhance muscle growth by supporting myogenic activity and regulating metabolic pathways involved in skeletal muscle development. However, the effect of specific nutrient supplementation on satellite cell (SC) activity and...
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in primary sensory neurons and has been proposed as a therapeutic target for pain management. However, the effects of repeated administration of a TRPA1 antago...
Understanding the direct relationship between skeletal muscle mass and strength in athletes is paramount for optimizing performance. Such a relationship has been poorly investigated in soccer players. In this work, a large number (n = 225) of elite s...
Background: Given its practical advantages in terms of time efficiency, joint compatibility and extensive adaptability, whole-body electromyostimulation (WB-EMS) has gained considerable attention as a training method among athletes and sportspeople a...
Accurate assessment of appendicular lean mass (ALM), an essential component for evaluating sarcopenia and nutritional status, typically requires dual-energy X-ray absorptiometry (DXA); however, its widespread clinical application is limited by cost a...
Background: Physical exercise is strongly recommended for breast cancer survivors due to its beneficial effects on physical function, metabolic health, and quality of life. Lactate, traditionally considered a metabolic byproduct of glycolysis, is inc...
Congenital Myasthenic Syndrome represents a complex and heterogeneous group of inherited neuromuscular disorders, which result from variants in genes involved in different pathophysiological mechanisms related to the neuromuscular junction. LRP4 (Low...
