Biology and Life Sciences Forum, Volume 7, Issue 1

During the search for new active compounds, at first, the focus is put mainly on the provision of compound activity towards considered targets. However, at the same time, or in the subsequent stages, the compound needs to be adequately profiled in te...

(1) Background: Various Machine Learning (ML) methods are applied for the prediction of individual efficiency of cancer treatment regimens. As features for ML, different multi-omics data may be used. We proposed a next-generation ML approach termed F...

Medium-chain triglycerides (MCT) have demonstrated a wide range of neuroprotective effects, although the mechanisms still remain poorly understood. Animal models are indispensable for such research. Metabolic effects of regular diet supplementation w...

Aberrant crypt foci (ACF) are early lesions in the neoplastic induction found in the rat colon of a carcinogenic model. ACF are one of the first changes in the colon that lead to colorectal cancer (CRC). Probiotics and fermented foods are well known...

Cutaneous melanoma (CM) is a public health issue and a significant challenge for scientists. At the dawn of the “omics era”, we witnessed groundbreaking advances in CM molecular stratification and therapeutic management assisted by genomi...

G-protein-coupled receptors (GPCR) belong to a large family of molecules eliciting different responses to a variety of signaling molecules. These receptors participate in various physiological functions such as metabolism, growth, immune responses, i...

There are numerous computational tools which support the design of new potential ligands. They assist in the evaluation of potential compound activity as well as in the optimization of compound physicochemical and pharmacokinetic properties. Nowadays...

The pharmacologic properties of gold compounds have been known since the end of the 19th century. In the last decade gold complexes have received increased attention due to the variety of their applications. Rhodopsin-like receptors are a family of p...

Objective. To study the effect of biopsychological age indicators on the likelihood and severity of COVID-19 disease in adults in 2020. We have examined 447 people aged 35–70 years using methods for assessing biological and psychological age in...

The metabolic syndrome is a cluster of conditions that occur together, increasing the risk of chronic diseases such as obesity, type II diabetes, or cardiovascular disease. Nutritional interventions improving inflammation, bioenergetics, and oxidativ...