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Diabetology, Volume 7, Issue 1

2026 January - 21 articles

Cover Story: Type 1 diabetes (T1D) is increasingly recognized as a neurodevelopmental condition as well as a metabolic disease. Because diagnosis often occurs during critical periods of brain maturation, children with T1D are uniquely vulnerable to cognitive injury from glycemic extremes. This narrative review synthesizes evidence linking diabetic ketoacidosis, severe hypoglycemia, chronic hyperglycemia, and glycemic variability with alterations in brain structure, functional connectivity, and cognitive performance. We highlight how early disease onset and longer duration amplify risk, and how modern diabetes technologies—such as continuous glucose monitoring and hybrid closed-loop insulin delivery—may help preserve neurocognitive development. Understanding and addressing these brain–metabolism interactions is essential for optimizing lifelong outcomes for children with T1D. View this paper
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Articles (21)

  • Article
  • Open Access
128 Views
16 Pages

Background/Objectives: Youth with type 1 diabetes (T1DM) face unique challenges in balancing dietary choices, physical health outcomes, and social–emotional well-being in school settings. This cross-sectional exploratory pilot study examined th...

  • Article
  • Open Access
258 Views
14 Pages

Camel Milk-Based Fermented Product “Inullact-Fito” Ameliorates Metabolic and Immunological Disturbances in Alloxan-Induced Diabetes

  • Ualikhan Zhumabayev,
  • Nursultan Nurdinov,
  • Ibragim Ishigov,
  • Rakhat Pernebekova,
  • Yerbolat Saruarov,
  • Bakhyt Baizakova,
  • Akbota Skenderova,
  • Bagdat Ashimbekova,
  • Perizat Tasenova and
  • Elmira Kozhambekova
  • + 2 authors

Background/Objectives: This study examined the metabolic, oxidative, immunological, and histomorphological effects of the multicomponent fermented biological product derived from camel milk, Inullact-Fito, in comparison to metformin in a rat model of...

  • Review
  • Open Access
328 Views
36 Pages

Artificial Intelligence Algorithms for Insulin Management and Hypoglycemia Prevention in Hospitalized Patients—A Scoping Review

  • Eileen R. Faulds,
  • Melanie Natasha Rayan,
  • Matthew Mlachak,
  • Kathleen M. Dungan,
  • Ted Allen and
  • Emily Patterson

Background: Dysglycemia remains a persistent challenge in hospital care. Despite advances in outpatient diabetes technology, inpatient insulin management largely depends on intermittent point-of-care glucose testing, static insulin dosing protocols a...

  • Article
  • Open Access
306 Views
21 Pages

Aerobic Training Modulates the Expression of Components of the mPTP Through the Reduction of Oxidative Stress in the Soleus Muscle of Streptozotocin-Induced Diabetic Rats

  • Luis Alberto Sánchez-Briones,
  • Sarai Sánchez-Duarte,
  • Sergio Márquez-Gamiño,
  • Karla Susana Vera-Delgado,
  • Montserrat Guadalupe Vera-Delgado,
  • Rocío Montoya-Pérez,
  • Cipriana Caudillo-Cisneros and
  • Elizabeth Sánchez-Duarte

Background/Objectives: In all types of diabetes, elevated blood glucose levels cause pathological changes in skeletal muscle, primarily due to oxidative stress, mitochondrial dysfunction, and excessive production of reactive oxygen species (ROS). Reg...

  • Article
  • Open Access
298 Views
16 Pages

Stakeholder Perspectives on Implementing DiabeText: Exploring Barriers and Facilitators for a Personalized Diabetes Self-Management SMS Intervention in Spain

  • Elena Gervilla-García,
  • Patricia García-Pazo,
  • Mireia Guillén-Solà,
  • Federico Leguizamo,
  • Ignacio Ricci-Cabello,
  • María Jesús Serrano-Ripoll,
  • Miquel Bennasar-Veny,
  • Maria Antònia Fiol-deRoque,
  • Escarlata Angullo-Martínez and
  • Rocío Zamanillo-Campos

Background/Objectives: Mobile health (mHealth) interventions can enhance chronic disease management, but their integration into public healthcare systems remains complex. DiabeText is the first SMS-based intervention in Spain delivering personalized...

  • Article
  • Open Access
165 Views
20 Pages

Purpose in Life and Insulin Resistance in a Large Occupational Cohort: Cross-Sectional Associations Using TyG, SPISE-IR, and METS-IR Indices

  • Pilar García Pertegaz,
  • Pedro Juan Tárraga López,
  • Irene Coll Campayo,
  • Carla Busquets-Cortés,
  • Ángel Arturo López-González and
  • José Ignacio Ramírez-Manent

Background: Insulin resistance (IR) is a key metabolic abnormality underlying type 2 diabetes and cardiometabolic diseases. Although lifestyle and sociodemographic determinants are well described, the role of psychosocial constructs—such as pur...

  • Article
  • Open Access
194 Views
12 Pages

Background/Objectives: The increasing availability of online health information underscores the importance of digital resources and internet use, especially for older adults. Despite the benefits, utilization of Welcome to Medicare (WTM) and Annual W...

  • Article
  • Open Access
439 Views
17 Pages

Effectiveness of a Community-Based Health Care Program on Glycemic Control Among Patients with Uncontrolled Type 2 Diabetes Mellitus: A Quasi-Experimental Study

  • Patcharin Phuwilert,
  • Supatra Noo-In,
  • Chitkamon Srichomphoo,
  • Jirarat Ruetrakul,
  • Ruchakron Kongmant and
  • Santisith Khiewkhern

Background: Type 2 diabetes mellitus (T2DM) is a major public health problem in Thailand, particularly in rural areas where individuals have limited access to structured diabetes care and education. Poor self-management contributes to uncontrolled gl...

  • Article
  • Open Access
228 Views
11 Pages

Background/Objectives: Type 2 diabetes (T2D), a chronic metabolic disorder characterized by systemic inflammation, disproportionately affects African American adolescents. Metformin may reduce inflammation beyond glycemic control; however, its impact...

  • Article
  • Open Access
274 Views
10 Pages

The Role of the Neutrophil-to-Lymphocyte Ratio in Patients with Diabetes and Atrial Fibrillation: Insights from the National Spanish Registry Sumamos-FA-SEMI

  • José Carlos Arévalo-Lorido,
  • Juana Carretero-Gómez,
  • Alberto Muela Molinero,
  • Esther Montero-Hernández,
  • Juan Bosco López-Sáez,
  • Maria Isabel González-Anglada,
  • Miguel Angel Vazquez-Ronda,
  • Jesús Castiella-Herrero,
  • José Pablo Miramontes-González and
  • on behalf of Sumamos-FA-SEMI Registry
  • + 1 author

Aim: To analyse the importance of inflammation in the disease burden and prognosis of patients with type 2 diabetes (T2DM) and atrial fibrillation (AF). We assessed these patients according to their neutrophil-to-lymphocyte ratio (NLR) values, examin...

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Diabetology - ISSN 2673-4540