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Diabetology, Volume 3, Issue 4

December 2022 - 12 articles

Cover Story: Nearly 40% of adults with type 2 diabetes (T2D) experience early morning rises in glucose due to increased hepatic glucose production, decreased glucose clearance, impaired insulin production and secretion, or a combination of these. Increasing prevalence of T2D and the frequency of poor glycemic control, coupled with low adherence to diabetes pharmacotherapy, highlights the need for lifestyle interventions to improve fasting glucose. This pilot study aimed to determine the acute effect of consuming almond butter as an evening snack on fasting and overnight interstitial glucose, compared to a no-snack control, in people with T2D not on insulin therapy. We utilized continuous glucose monitoring to analyze overnight glucose trends and to evaluate individual differences in glycemic excursions. View this paper
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Articles (12)

  • Review
  • Open Access
3 Citations
4,655 Views
5 Pages

12 December 2022

A high consumption of sugar leads to an increase in caloric intake, which in turn will lead to a higher risk of developing health issues. Foods contain both naturally occurring sugars and added sugars. The World Health Organization recommends that th...

  • Study Protocol
  • Open Access
3 Citations
7,147 Views
14 Pages

Multicenter, Open Label, Randomized Controlled Superiority Trial for Availability to Reduce Nocturnal Urination Frequency: Study Protocol for a TOP-STAR Study

  • Hanako Nakajima,
  • Hiroshi Okada,
  • Akinori Kogure,
  • Takafumi Osaka,
  • Takeshi Tsutsumi,
  • Toru Tanaka,
  • Goji Hasegawa,
  • Shinichi Mogami,
  • Kazuteru Mitsuhashi and
  • Noriyuki Kitagawa
  • + 10 authors

7 December 2022

Nocturia is a common disease in patients with type 2 diabetes mellitus that can reduce the quality of life. Sodium glucose co-transporter 2 (SGLT2) inhibitors increase the urine volume and are often discontinued when polyuria occurs, although tofogli...

  • Commentary
  • Open Access
1 Citations
4,888 Views
5 Pages

Insulin Injection-Related Skin Lipodystrophies: Blemish or Pathology?

  • Felice Strollo,
  • Ersilia Satta and
  • Sandro Gentile

1 December 2022

The number of adult individuals with insulin-treated diabetes mellitus (DM) is steadily increasing worldwide. The main local complications of insulin injection are lipohypertrophies (LHs), i.e., subcutaneous nodules consisting of aggregates of macro-...

  • Review
  • Open Access
2 Citations
10,496 Views
9 Pages

22 November 2022

The circadian rhythm is essential in order to maintain metabolic homeostasis and insulin sensitivity. Disruption of circadian mechanisms is associated with the development of metabolic diseases, such as diabetes. Lifestyle changes such as an equilibr...

  • Review
  • Open Access
8 Citations
5,926 Views
10 Pages

10 November 2022

Glycotoxins include the group of advanced glycation end-products (AGEs) and their precursors, most of them highly reactive intermediary compounds of sugar metabolism. Glycotoxins and products of the Maillard reaction are present in high concentration...

  • Review
  • Open Access
7 Citations
23,711 Views
13 Pages

The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development

  • Mariana S. Diniz,
  • Carolina Tocantins,
  • Luís F. Grilo and
  • Susana P. Pereira

7 November 2022

Type 2 diabetes (T2D) has increased worldwide at an alarming rate. Metabolic syndrome (MetS) is a major risk factor for T2D development. One of the main reasons for the abrupt rise in MetS incidence, besides a sedentary lifestyle, is the westernized...

  • Article
  • Open Access
2 Citations
3,077 Views
22 Pages

Augmentation and Evaluation of an Olive Oil Based Polyherbal Combination against Diabetic Cardiomyopathy in Experimental Model of Rodents

  • Arshiya Shamim,
  • Hefazat H. Siddiqui,
  • Tarique Mahmood,
  • Tanveer A. Wani,
  • Seema Zargar,
  • Mohammad Haris Siddiqui,
  • Alvina Farooqui,
  • Farogh Ahsan,
  • Mohammad Shariq and
  • Saba Parveen
  • + 3 authors

2 November 2022

Diabetes mellitus is a metabolic disorder that is prima facie a cause for numerous macro and micro vascular complications. A common macroscopic complication associated with diabetes is cardiomyopathy. Cardiomyopathy refers to diseases of the heart mu...

  • Feature Paper
  • Review
  • Open Access
37 Citations
27,433 Views
12 Pages

Impact of Dietary Sugars on Gut Microbiota and Metabolic Health

  • Karina Garcia,
  • Gonçalo Ferreira,
  • Flávio Reis and
  • Sofia Viana

28 October 2022

Excessive sugar consumption is a risk factor for the development of several disorders, including metabolic, cardiovascular, neurological conditions and even some cancers, and has been linked to increased morbidity and mortality. The popularization of...

  • Article
  • Open Access
3 Citations
2,463 Views
10 Pages

21 October 2022

Impaired glucocorticoid signaling in diabetes mellitus and its relation to suppressed immune function and hyperglycemia during acute stroke has been shown to be detrimental. Therefore, the aim of this study was to examine the effect of glucocorticoid...

  • Article
  • Open Access
4 Citations
2,662 Views
15 Pages

Investigating the Protective Effects of a Rhenium (V) Compound with Uracil-Derived Ligands on Liver Damage Associated with Prediabetes in Diet-Induced Prediabetic Rats

  • Angezwa Siboto,
  • Akinjide Moses Akinnuga,
  • Muhammed Bilaal Ismail,
  • Irvin Noel Booysen,
  • Ntethelelo Hopewell Sibiya,
  • Phikelelani Ngubane and
  • Andile Khathi

17 October 2022

Non-alcoholic fatty liver disease (NAFLD) is associated with prediabetes and can be treated by using a combination of metformin and dietary modification. However, people often fail to adhere to dietary modifications and become more dependent on pharm...

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Diabetology - ISSN 2673-4540