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Article

Influence of Host-Related Factors and Exposure to Mosquito Bites on the Dynamics of Antibody Response to Plasmodium falciparum Antigens

by
Kakou G. Aka
1,2,
Serge S. Yao
3,
Eric A. Gbessi
3,
Akré M. Adja
1,4,
Vincent Corbel
2,
Alphonsine A. Koffi
1,
Christophe Rogier
5,6,
Serge B. Assi
1,7,
Offianan A. Toure
3,
Franck Remoue
1,2 and
Anne Poinsignon
1,2,*
1
Institut Pierre Richet/Institut National de Santé Publique, Bouaké, Côte d’Ivoire
2
MIVEGEC, University of Montpellier, IRD, CNRS, 34000 Montpellier, France
3
Unité de Paludologie, Institut Pasteur de Côte d’Ivoire, Abidjan 01 BP 490, Côte d’Ivoire
4
UFR Biosciences, University Felix Houphouet Boigny, Abidjan 01 BP V34, Côte d’Ivoire
5
Primum Vitare!, Paris, France
6
Institut Pasteur de Madagascar, Antananarivo 101, Madagascar
7
Programme National de Lutte contre le Paludisme, Abidjan, Côte d’Ivoire
*
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2021, 6(4), 185; https://doi.org/10.3390/tropicalmed6040185
Submission received: 9 September 2021 / Revised: 30 September 2021 / Accepted: 11 October 2021 / Published: 18 October 2021
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Abstract

Humoral immunity to Plasmodium falciparum is acquired after repeated infections, and can lead to clinical protection. This study aimed to evaluate how human-, parasite-, and environment-related determinants can modulate the dynamics of IgG responses to Plasmodium falciparum after an infection. Individuals (n = 68, average age = 8.2 years) with uncomplicated malaria were treated with ACT and followed up for 42 days. IgG responses to P. falciparum merozoite antigens (PfMSP1, PfMSP3, PfAMA1, PfGLURP-R0), to whole schizont extract (PfSchz), and to Anopheles gSG6-P1 and Aedes Nterm–34 kDa salivary peptides were measured. Regression analyses were used to identify factors that influence the dynamics of IgG response to P. falciparum antigen between D0 and D42, including demographic and biological factors and the level of exposure to mosquito bites. The dynamics of IgG response to P. falciparum differed according to the antigen. According to multivariate analysis, IgG responses to PfSchz and to PfGLURP-R0 appear to be affected by exposure to Aedes saliva and are associated with age, parasite density, and anti-Plasmodium pre-existing immune response at study inclusion. The present work shows that human exposure to Aedes saliva may contribute, in addition to other factors, to the regulation of anti-Plasmodium immune responses during a natural infection.
Keywords: Plasmodium falciparum; malaria; Anopheles; Aedes; humoral acquired immunity; saliva; immunomodulation; exposure Plasmodium falciparum; malaria; Anopheles; Aedes; humoral acquired immunity; saliva; immunomodulation; exposure

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MDPI and ACS Style

Aka, K.G.; Yao, S.S.; Gbessi, E.A.; Adja, A.M.; Corbel, V.; Koffi, A.A.; Rogier, C.; Assi, S.B.; Toure, O.A.; Remoue, F.; et al. Influence of Host-Related Factors and Exposure to Mosquito Bites on the Dynamics of Antibody Response to Plasmodium falciparum Antigens. Trop. Med. Infect. Dis. 2021, 6, 185. https://doi.org/10.3390/tropicalmed6040185

AMA Style

Aka KG, Yao SS, Gbessi EA, Adja AM, Corbel V, Koffi AA, Rogier C, Assi SB, Toure OA, Remoue F, et al. Influence of Host-Related Factors and Exposure to Mosquito Bites on the Dynamics of Antibody Response to Plasmodium falciparum Antigens. Tropical Medicine and Infectious Disease. 2021; 6(4):185. https://doi.org/10.3390/tropicalmed6040185

Chicago/Turabian Style

Aka, Kakou G., Serge S. Yao, Eric A. Gbessi, Akré M. Adja, Vincent Corbel, Alphonsine A. Koffi, Christophe Rogier, Serge B. Assi, Offianan A. Toure, Franck Remoue, and et al. 2021. "Influence of Host-Related Factors and Exposure to Mosquito Bites on the Dynamics of Antibody Response to Plasmodium falciparum Antigens" Tropical Medicine and Infectious Disease 6, no. 4: 185. https://doi.org/10.3390/tropicalmed6040185

APA Style

Aka, K. G., Yao, S. S., Gbessi, E. A., Adja, A. M., Corbel, V., Koffi, A. A., Rogier, C., Assi, S. B., Toure, O. A., Remoue, F., & Poinsignon, A. (2021). Influence of Host-Related Factors and Exposure to Mosquito Bites on the Dynamics of Antibody Response to Plasmodium falciparum Antigens. Tropical Medicine and Infectious Disease, 6(4), 185. https://doi.org/10.3390/tropicalmed6040185

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