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2,342 Results Found

  • Article
  • Open Access
2 Citations
2,426 Views
9 Pages

Assessment of a Commercial Real-Time PCR Assay (Vitassay qPCR Malaria 5 Test) to Detect Human Malaria Infection in Travelers Returning to France

  • Marylin Madamet,
  • Rémy Amalvict,
  • Nicolas Benoit,
  • French National Reference Centre for Imported Malaria Study Group and
  • Bruno Pradines

10 November 2022

Malaria is the most common human parasitic disease in the world with the highest morbidity and mortality. Due to the severity of malaria caused by Plasmodium falciparum and the urgency of therapeutic management, quick and reliable diagnosis is requir...

  • Article
  • Open Access
2 Citations
3,756 Views
12 Pages

Comparison of SD Bioline Malaria Ag Pf/Pan and Acro Malaria P.f./P.v./Pan with Microscopy and Real Time PCR for the Diagnosis of Human Plasmodium Species

  • Marylin Madamet,
  • Isabelle Fonta,
  • Joel Mosnier,
  • Nicolas Benoit,
  • Rémy Amalvict,
  • Sébastien Briolant,
  • French National Reference Centre for Imported Malaria Study Group and
  • Bruno Pradines

The early diagnosis of malaria is crucial to controlling morbidity and mortality. The World Health Organization (WHO) recommends diagnosing malaria either using light microscopy or a malaria rapid diagnostic test (RDT). Most RDTs use antibodies to de...

  • Article
  • Open Access
16 Citations
6,527 Views
22 Pages

The Evolution of the Malaria Clinic: The Cornerstone of Malaria Elimination in Thailand

  • Prayuth Sudathip,
  • Suravadee Kitchakarn,
  • Krongthong Thimasarn,
  • Deyer Gopinath,
  • Tinzar Naing,
  • Omar Sajjad and
  • Sumetha Hengprasert

Background: Malaria Clinics (MCs) have served communities in Thailand since 1965 and are still playing a critical role in providing early diagnosis and effective treatment of malaria. Methods: We reviewed six decades of published manuscripts, article...

  • Case Report
  • Open Access
7 Citations
5,145 Views
5 Pages

Transfusion-Transmitted Malaria of Plasmodium malariae in Palermo, Sicily

  • Jessica Pulvirenti,
  • Maurizio Musso,
  • Teresa Fasciana,
  • Antonio Cascio,
  • Maria Rita Tricoli,
  • Natascia Oliveri,
  • Maria Favarò,
  • Orazia Diquattro and
  • Anna Giammanco

16 November 2021

Transfusion-transmitted malaria (TTM) is a rare occurrence with serious consequences for the recipient. In non-endemic areas, the incidence of transmission of malaria by transfusion is very low. We report a clinical case of transfusion-transmitted ma...

  • Review
  • Open Access
307 Citations
47,917 Views
17 Pages

Malaria: The Past and the Present

  • Jasminka Talapko,
  • Ivana Škrlec,
  • Tamara Alebić,
  • Melita Jukić and
  • Aleksandar Včev

Malaria is a severe disease caused by parasites of the genus Plasmodium, which is transmitted to humans by a bite of an infected female mosquito of the species Anopheles. Malaria remains the leading cause of mortality around the world, and early diag...

  • Review
  • Open Access
18 Citations
12,223 Views
23 Pages

Recent Advances in the Treatment of Malaria

  • Jawaher M. Alghamdi,
  • Arwa A. Al-Qahtani,
  • Fatimah S. Alhamlan and
  • Ahmed A. Al-Qahtani

Malaria is still one of the major global health challenges affecting millions annually, particularly in non-Mediterranean Africa and Southeast Asia. Over the past two decades, substantial progress has been made in reducing malaria-related morbidity a...

  • Article
  • Open Access
11 Citations
3,260 Views
10 Pages

Two-Year Scale-Up of Seasonal Malaria Chemoprevention Reduced Malaria Morbidity among Children in the Health District of Koutiala, Mali

  • Hamma Maiga,
  • Jean Gaudart,
  • Issaka Sagara,
  • Modibo Diarra,
  • Amadou Bamadio,
  • Moussa Djimde,
  • Samba Coumare,
  • Boubou Sangare,
  • Yeyia Dicko and
  • Abdoulaye A. Djimde
  • + 5 authors

Background: Previous controlled studies demonstrated seasonal malaria chemoprevention (SMC) reduces malaria morbidity by >80% in children aged 3–59 months. Here, we assessed malaria morbidity after large-scale SMC implementation during a pil...

  • Article
  • Open Access
6 Citations
3,941 Views
12 Pages

Evolution of Malaria Incidence in Five Health Districts, in the Context of the Scaling up of Seasonal Malaria Chemoprevention, 2016 to 2018, in Mali

  • Aissata Sacko,
  • Issaka Sagara,
  • Ibrahima Berthé,
  • Modibo Diarra,
  • Mady Cissoko,
  • Souleymane S. Diarra,
  • Drissa Coulibaly,
  • Moussa Sanogo and
  • Alassane Dicko

Context: In Mali, malaria transmission is seasonal, exposing children to high morbidity and mortality. A preventative strategy called Seasonal Malaria Chemoprevention (SMC) is being implemented, consisting of the distribution of drugs at monthly inte...

  • Review
  • Open Access
5 Citations
4,833 Views
12 Pages

It Is Time to Strengthen the Malaria Control Policy of the Democratic Republic of Congo and Include Schools and School-Age Children in Malaria Control Measures

  • Sabin S. Nundu,
  • Shirley V. Simpson,
  • Hiroaki Arima,
  • Jean-Jacques Muyembe,
  • Toshihiro Mita,
  • Steve Ahuka and
  • Taro Yamamoto

Despite a decade of sustained malaria control, malaria remains a serious public health problem in the Democratic Republic of Congo (DRC). Children under five years of age and school-age children aged 5–15 years remain at high risk of symptomati...

  • Article
  • Open Access
6 Citations
3,210 Views
11 Pages

Anopheles species composition, abundance, and Plasmodium natural infection are important aspects to assess malaria transmission risk. In this study, these aspects were evaluated in a large number of localities in the most important malaria-endemic re...

  • Review
  • Open Access
15 Citations
8,962 Views
14 Pages

Novel Therapeutics for Malaria

  • Haitham Alaithan,
  • Nirbhay Kumar,
  • Mohammad Z. Islam,
  • Angelike P. Liappis and
  • Victor E. Nava

Malaria is a potentially fatal disease caused by protozoan parasites of the genus Plasmodium. It is responsible for significant morbidity and mortality in endemic countries of the tropical and subtropical world, particularly in Africa, Southeast Asia...

  • Article
  • Open Access
4 Citations
4,473 Views
8 Pages

Comparative Assessment of the Sensitivity of Ten Commercial Rapid Diagnostic Test Kits for the Detection of Plasmodium

  • Mathieu Gendrot,
  • Marylin Madamet,
  • Isabelle Fonta,
  • Nicolas Benoit,
  • Rémy Amalvict,
  • Joel Mosnier,
  • French National Reference Centre for Imported Malaria Study Group and
  • Bruno Pradines

16 September 2022

Malaria is one of the most common tropical diseases encountered by members of the French military who are deployed in operations under constrained conditions in malaria-endemic areas. Blood smear microscopy—the gold standard for malaria diagnos...

  • Article
  • Open Access
18 Citations
5,347 Views
10 Pages

Analysis of Fifty Years of Severe Malaria Worldwide Research

  • Jose A. Garrido-Cardenas,
  • Lilia González-Cerón,
  • Federico García-Maroto,
  • José Cebrián-Carmona,
  • Francisco Manzano-Agugliaro and
  • Concepción M. Mesa-Valle

24 February 2023

This study analyzed fifty years of severe malaria research worldwide. Malaria is a parasitic disease that continues to have a significant impact on global health, particularly in sub-Saharan Africa. Severe malaria, a severe and often fatal form of th...

  • Article
  • Open Access
10 Citations
3,583 Views
15 Pages

Diagnostic Accuracy of CareStart™ Malaria HRP2 and SD Bioline Pf/PAN for Malaria in Febrile Outpatients in Varying Malaria Transmission Settings in Cameroon

  • Innocent Mbulli Ali,
  • Akindeh Mbuh Nji,
  • Jacob Chefor Bonkum,
  • Marcel Nyuylam Moyeh,
  • Guenang Kenfack Carole,
  • Agni Efon,
  • Solange Dabou,
  • Valery Pacome Kom Tchuenkam,
  • Calvino Tah and
  • Wilfred Fon Mbacham
  • + 3 authors

Background: There was an increase in the number of malaria cases in Cameroon in 2018 that could reflect changes in provider practice, despite effective interventions. In this study, we assessed the diagnostic performance of two malaria rapid diagnost...

  • Case Report
  • Open Access
622 Views
9 Pages

Background: Although China has eliminated indigenous malaria, imported cases, particularly among young and middle-aged workers returning from Africa, constitute a major challenge for current epidemic prevention and control. In contrast, imported mala...

  • Commentary
  • Open Access
726 Views
7 Pages

Climate, Interventions, and Malaria Outcomes in a Warming World: Towards Climate-Smart Malaria Control in Kenya

  • Bryan O. Nyawanda,
  • Eric Ochomo,
  • James D. Otieno,
  • Kibor Keitany,
  • Beatrice K. Machini and
  • Penelope Vounatsou

Malaria control in sub-Saharan Africa lies at the intersection of changing climate suitability and the scale-up of vector control and case management. Drawing on recent evidence from Kenya, we argue that climate variability already exerts effects on...

  • Article
  • Open Access
6 Citations
3,297 Views
10 Pages

Molecular Method Is Essential to Identify Asymptomatic Malaria Reservoirs: A Successful Experience in the Malaria Elimination Program in Iran

  • Jebreil Shamseddin,
  • Amin Ghanbarnejad,
  • Abdoljabbar Zakeri,
  • Farshid Abedi,
  • Shaghayegh Khojasteh and
  • Habibollah Turki

2 December 2022

Background: The accurate diagnosis of malaria cases, especially asymptotic and low-parasitemia patients, using robust molecular methods (nested-PCR) have been emphasized. The goal of this study was to detect active cases of malaria in areas with a hi...

  • Review
  • Open Access
2 Citations
8,421 Views
30 Pages

Emerging Molecular Mechanisms in Malaria Pathogenesis and Novel Therapeutic Approaches: A Focus on P. falciparum Malaria

  • Adekunle Sanyaolu,
  • Aleksandra Marinkovic,
  • Stephanie Prakash,
  • Vyshnavy Balendra,
  • Omar Shazley,
  • Tatiana Gardellini,
  • Abdul Jan,
  • Kokab Younis,
  • Chuku Okorie and
  • Ricardo Izurieta

17 July 2025

Malaria is still one of the biggest global health problems, especially in parts of the world, such as sub-Saharan Africa, which remains most heavily affected. Despite significant advancements in testing, treatment, and prevention, malaria continues t...

  • Review
  • Open Access
34 Citations
19,013 Views
28 Pages

Malaria Prophylaxis: A Comprehensive Review

  • Francesco Castelli,
  • Silvia Odolini,
  • Beatrice Autino,
  • Emanuele Foca and
  • Rosario Russo

13 October 2010

The flow of international travellers to and from malaria-endemic areas, especially Africa, has increased in recent years. Apart from the very high morbidity and mortality burden imposed on malaria-endemic areas, imported malaria is the main cause of...

  • Case Report
  • Open Access
4,352 Views
6 Pages

21 September 2022

Plasmodium malariae is a neglected human malaria parasite with low parasitemia that often results in the misdiagnosis and underestimation of the actual disease burden of this pathogen. Microscopy is the best diagnostic tool, despite the fact that rap...

  • Review
  • Open Access
9 Citations
7,667 Views
17 Pages

Malaria Vaccine Development and How External Forces Shape It: An Overview

  • Veronique Lorenz,
  • Gabriele Karanis and
  • Panagiotis Karanis

The aim of this paper is to analyse the current status and scientific value of malaria vaccine approaches and to provide a realistic prognosis for future developments. We systematically review previous approaches to malaria vaccination, address how...

  • Feature Paper
  • Article
  • Open Access
8 Citations
4,736 Views
17 Pages

Malaria threatens the lives of many people throughout the world. To counteract its spread, knowledge of the prevalence of malaria and the effectiveness of intervention strategies is of great importance. The aim of this study was to assess (1) the spr...

  • Review
  • Open Access
9 Citations
5,507 Views
16 Pages

Malaria remains an ongoing public health challenge, with over 600,000 deaths in 2021, of which approximately 96% occurred in Africa. Despite concerted efforts, the goal of global malaria elimination has stalled in recent years. This has resulted in w...

  • Review
  • Open Access
22 Citations
4,508 Views
16 Pages

Global Cross-Border Malaria Control Collaborative Initiatives: A Scoping Review

  • Tichaona Fambirai,
  • Moses John Chimbari and
  • Pisirai Ndarukwa

Malaria remains a global disease of public health concern. Malaria control collaborative initiatives are widely being adopted to reduce malaria burden by various countries. This review sought to describe current and past cross-border malaria control...

  • Review
  • Open Access
89 Citations
15,833 Views
20 Pages

Vector-borne parasitic infectious diseases are important causes of morbidity and mortality globally. Malaria is one of the most common vector-borne parasitic infection and is caused by five Plasmodium species, namely P. falciparum, P. vivax, P. ovale...

  • Article
  • Open Access
12 Citations
4,284 Views
20 Pages

Stratification and Adaptation of Malaria Control Interventions in Chad

  • Mahamat Idriss Djaskano,
  • Mady Cissoko,
  • Mahamat Saleh Issakha Diar,
  • Demba Kodindo Israel,
  • Kerah Hinzoumbé Clément,
  • Aicha Mohamed Ali,
  • Makido Dormbaye,
  • Issa Mahamat Souleymane,
  • Adam Batrane and
  • Issaka Sagara

Malaria remains the leading cause of morbidity and mortality in Chad. The World Health Organization (WHO) has recommended that endemic countries stratify malaria to guide interventions. Thus, the Republic of Chad has initiated a stratification proces...

  • Article
  • Open Access
1 Citations
3,078 Views
19 Pages

Revisiting the Impact of Dams on Malaria and Agriculture

  • Sebastien Mary,
  • Kyle Craven,
  • Avraham Stoler and
  • Sarah Shafiq

We estimate the effect of large dams on malaria incidence in India between 1975 and 1995. We combine instrumental variables approach with a panel model with unobserved common factors allowing us to fully capture the endogeneity of dam location and un...

  • Review
  • Open Access
1 Citations
5,797 Views
19 Pages

Malaria Vaccines and Global Equity: A Scoping Review of Current Progress and Future Directions

  • Rajesh Perumbilavil Kaithamanakallam,
  • Tirath Patel,
  • Bharati Balachandran,
  • Neville Fernandez,
  • Joseph Jillwin,
  • Dharambir Kashyap,
  • Aparna Shivaprasad,
  • Uttam Udayan,
  • Pragnesh Kalyandrug and
  • Prasanna Honnavar
  • + 1 author

The journey toward a viable malaria vaccine, initiated in 1965, reached a major milestone in 2021 with the WHO’s endorsement of RTS,S/AS01, a recombinant protein-based malaria vaccine. This progress continued with the 2023 approval of the R21/M...

  • Review
  • Open Access
116 Citations
23,584 Views
15 Pages

Malaria is one of the leading causes of death worldwide. According to the World Health Organization’s (WHO’s) world malaria report for 2018, there were 228 million cases and 405,000 deaths worldwide. This paper reviews and highlights the...

  • Review
  • Open Access
23 Citations
9,696 Views
19 Pages

Progress in the Development of Subunit Vaccines against Malaria

  • Mariusz Skwarczynski,
  • Saranya Chandrudu,
  • Berta Rigau-Planella,
  • Md. Tanjir Islam,
  • Yee S. Cheong,
  • Genan Liu,
  • Xiumin Wang,
  • Istvan Toth and
  • Waleed M. Hussein

Malaria is a life-threatening disease and one of the main causes of morbidity and mortality in the human population. The disease also results in a major socio-economic burden. The rapid spread of malaria epidemics in developing countries is exacerbat...

  • Review
  • Open Access
58 Citations
22,052 Views
11 Pages

21 July 2010

This review summarizes progress in treating severe and complicated malaria, which are global problems, claiming at least one million lives annually, and have been accompanied by advances in our understanding of the pathogenesis of severe malaria comp...

  • Article
  • Open Access
6 Citations
3,370 Views
10 Pages

Malaria during COVID-19 Travel Restrictions in Makkah, Saudi Arabia

  • Sami Melebari,
  • Abdul Hafiz,
  • Kamal H. Alzabeedi,
  • Abdullah A. Alzahrani,
  • Yehya Almalki,
  • Renad J. Jadkarim,
  • Fadel Qabbani,
  • Rowaida Bakri,
  • Naif A. Jalal and
  • Othman Fallatah
  • + 5 authors

Malaria is a parasitic infection that may result in an acute, life-threatening illness. It is a major public health problem in the tropical world. The disease is caused by the parasites of the genus Plasmodium and is transmitted by female Anopheles m...

  • Commentary
  • Open Access
4 Citations
2,969 Views
9 Pages

8 November 2022

Drugs have been used to prevent malaria for centuries, but only recently have they been used on a large scale to prevent malaria in the resident population of malaria endemic areas in sub-Saharan Africa. This paper discusses some of the reasons for t...

  • Review
  • Open Access
30 Citations
23,131 Views
12 Pages

23 December 2022

In sub-Saharan Africa, malaria is a leading cause of mortality and morbidity. As a result of the interplay between many factors, the control of this disease can be challenging. However, few studies have demonstrated malaria’s complexity, contro...

  • Review
  • Open Access
32 Citations
6,908 Views
15 Pages

28 February 2018

Despite a global effort to develop an effective vaccine, malaria is still a significant health problem. Much of the pathology of malaria is immune mediated. This suggests that host immune responses have to be finely regulated. The innate immune syste...

  • Review
  • Open Access
12 Citations
6,479 Views
24 Pages

Malaria is the most common vector-borne parasitic infection causing significant human morbidity and mortality in nearly 90 tropical/sub-tropical countries worldwide. Significant differences exist in the incidence of malaria cases, dominant Plasmodium...

  • Article
  • Open Access
3 Citations
2,564 Views
19 Pages

The Influence of Climate Variables on Malaria Incidence in Vanuatu

  • Jade Sorenson,
  • Andrew B. Watkins and
  • Yuriy Kuleshov

22 January 2025

Malaria, a climate-sensitive mosquito-borne disease, is widespread in tropical and subtropical regions, and its elimination is a global health priority. Malaria is endemic to Vanuatu, where elimination campaigns have been implemented with varied succ...

  • Review
  • Open Access
14 Citations
10,936 Views
14 Pages

Aptamer Technology: Adjunct Therapy for Malaria

  • Nik Abdul Aziz Nik Kamarudin,
  • Nurul Adila Mohammed and
  • Khairul Mohd Fadzli Mustaffa

Malaria is a life-threatening parasitic infection occurring in the endemic areas, primarily in children under the age of five, pregnant women, and patients with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV)/(AIDS) as well...

  • Article
  • Open Access
17 Citations
8,776 Views
15 Pages

Spatiotemporal Clustering Analysis of Malaria Infection in Pakistan

  • Muhammad Farooq Umer,
  • Shumaila Zofeen,
  • Abdul Majeed,
  • Wenbiao Hu,
  • Xin Qi and
  • Guihua Zhuang

Despite tremendous progress, malaria remains a serious public health problem in Pakistan. Very few studies have been done on spatiotemporal evaluation of malaria infection in Pakistan. The study aimed to detect the spatiotemporal pattern of malaria i...

  • Feature Paper
  • Review
  • Open Access
24 Citations
11,519 Views
20 Pages

Global Fight against Malaria: Goals and Achievements 1900–2022

  • Marc Thellier,
  • Ayawovi Arlene Jessicka Gemegah and
  • Ilhame Tantaoui

24 September 2024

This article examines the historical and ongoing efforts to fight malaria, a parasitic disease caused by Plasmodium species and transmitted by Anopheles mosquitoes. Despite over a century of control efforts, malaria remains a major global health issu...

  • Article
  • Open Access
5 Citations
5,547 Views
16 Pages

A Retrospective Review on Severe Malaria in Colombia, 2007–2020

  • Jaime Carmona-Fonseca,
  • Mario J. Olivera and
  • María F. Yasnot-Acosta

Background: Knowledge of severe malaria (SM) or complicated malaria is insufficient in all its components. The least known type is the one associated with Plasmodium vivax, compared to that caused by P. falciparum. The aim of this study was to provid...

  • Article
  • Open Access
13 Citations
4,059 Views
12 Pages

Evaluating COVID-19-Related Disruptions to Effective Malaria Case Management in 2020–2021 and Its Potential Effects on Malaria Burden in Sub-Saharan Africa

  • Paulina A. Dzianach,
  • Susan F. Rumisha,
  • Jailos Lubinda,
  • Adam Saddler,
  • Mauricio van den Berg,
  • Yalemzewod A. Gelaw,
  • Joseph R. Harris,
  • Annie J. Browne,
  • Francesca Sanna and
  • Daniel J. Weiss
  • + 6 authors

The COVID-19 pandemic has led to far-reaching disruptions to health systems, including preventative and curative services for malaria. The aim of this study was to estimate the magnitude of disruptions in malaria case management in sub-Saharan Africa...

  • Article
  • Open Access
2 Citations
2,945 Views
14 Pages

Different villages in a township or an area exhibit different malaria endemicities. This study aimed to investigate malaria preventive practices among people residing in different villages with stratified malaria endemicity in a township in Myanmar....

  • Brief Report
  • Open Access
18 Citations
9,307 Views
7 Pages

Tafenoquine (an 8-aminoquinoline) was approved by the Food and Drug Administration (FDA) in 2018 for the radical cure of Plasmodium vivax malaria and preventive action against malaria. Despite the fact that the mechanism of action of the drug remains...

  • Review
  • Open Access
9 Citations
4,420 Views
12 Pages

Narrative Review of the Control and Prevention of Knowlesi Malaria

  • Ahmad Hazim Mohammad,
  • Nurul Athirah Naserrudin,
  • Syed Sharizman Syed Abdul Rahim,
  • Jenarun Jelip,
  • Azman Atil,
  • Mohd Fazeli Sazali,
  • Adora J. Muyou,
  • Priya Dharishini Kunasagran,
  • Nornazirah Ahmad Kamarudin and
  • Mohd Rohaizat Hassan
  • + 3 authors

Despite the reduction in the number of cases of human malaria throughout the world, the incidence rate of knowlesi malaria is continuing to rise, especially in Southeast Asia. The conventional strategies for the prevention and control of human malari...

  • Review
  • Open Access
30 Citations
7,821 Views
16 Pages

Pre-Erythrocytic Vaccines against Malaria

  • Camila Marques-da-Silva,
  • Kristen Peissig and
  • Samarchith P. Kurup

Malaria, caused by the protozoan Plasmodium, is a devastating disease with over 200 million new cases reported globally every year. Although immunization is arguably the best strategy to eliminate malaria, despite decades of research in this area we...

  • Review
  • Open Access
30 Citations
7,555 Views
21 Pages

Review of Microdevices for Hemozoin-Based Malaria Detection

  • Vitória Baptista,
  • Weng Kung Peng,
  • Graça Minas,
  • Maria Isabel Veiga and
  • Susana O. Catarino

11 February 2022

Despite being preventable and treatable, malaria still puts almost half of the world’s population at risk. Thus, prompt, accurate and sensitive malaria diagnosis is crucial for disease control and elimination. Optical microscopy and immuno-rapi...

  • Article
  • Open Access
3 Citations
7,139 Views
18 Pages

The Epidemiology of Malaria in Kutubu, Southern Highlands Province, Papua New Guinea, before and during a Private Sector Initiative for Malaria Control

  • Marshall Feterl,
  • Patricia Graves,
  • Liesel Seehofer,
  • Jeffery Warner,
  • Peter Wood,
  • Kevin Miles and
  • Ross Hutton

Papua New Guinea (PNG) has a significant malaria burden, is resource constrained, and has isolated populations with limited access to health services. Home-based management is a key element of the national program that supports strategies of early de...

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