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Tropical Medicine and Infectious Disease, Volume 10, Issue 2

2025 February - 30 articles

Cover Story: Schistosomiasis in the Philippines, caused by the blood fluke Schistosoma japonicum, persists despite decades of preventative chemotherapy. The parasite’s life cycle involves a snail intermediate host and 46 potential mammalian definitive hosts, contributing to a complex epidemiology influenced by environmental, socioeconomic and biological factors. The control and eventual elimination of S. japonicum requires management of these animal hosts and new interventions for the human hosts, including health education and water, sanitation, and the hygiene (WASH) infrastructure. In this review, we examine the status and epidemiology of S. japonicum in the Philippines with an overview of the current control program and what needs to be accomplished to control and eliminate this disease in the country. View this paper
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Articles (30)

  • Article
  • Open Access
1 Citations
4,118 Views
11 Pages

Acute Respiratory Viral Infections Among Adult Patients in Edirne, Turkey

  • Sebnem Bukavaz,
  • Kultural Gungor,
  • Merve Köle and
  • Galip Ekuklu

Background/Objectives: This study aimed to evaluate the prevalence of viral agents identified by Multiplex PCR in acute respiratory viral infection (ARVI) patients at Edirne Sultan 1, Murat State Hospital, from April 2023 to April 2024, and to invest...

  • Article
  • Open Access
2,522 Views
12 Pages

Monitoring of Pathogens Carried by Imported Flies and Cockroaches at Shenzhen Ports

  • Siqi Zhang,
  • Chunzhong Zhao,
  • Guoping Liu,
  • Liwei Guo,
  • Ran Zhang,
  • Junyu Yan,
  • Jianan He and
  • Cheng Guo

This study tested the efficacy of xenomonitoring using contaminated flies and cockroaches at ports in Shenzhen by analysing sample data from imported flies and cockroaches from October 2023 to April 2024 to identify the pathogens they carried. Among...

  • Article
  • Open Access
6 Citations
3,903 Views
24 Pages

Background and Objective: Air pollution poses significant risks to global public health and has well-established links to respiratory diseases. This study investigates the associations between air pollution markers—Air Quality Index (AQI), ambi...

  • Article
  • Open Access
2,031 Views
24 Pages

The Effect of a Life-Stage Based Intervention on Depression in Youth Living with HIV in Kenya and Uganda: Results from the SEARCH-Youth Trial

  • Florence Mwangwa,
  • Jason Johnson-Peretz,
  • James Peng,
  • Laura B. Balzer,
  • Janice Litunya,
  • Janet Nakigudde,
  • Douglas Black,
  • Lawrence Owino,
  • Cecilia Akatukwasa and
  • Theodore Ruel
  • + 7 authors

Depression among adolescents and young adults with HIV affects both their wellbeing and clinical care outcomes. Integrated care models are needed. We hypothesized that the SEARCH-Youth intervention, a life-stage-based care model that improved viral s...

  • Systematic Review
  • Open Access
4 Citations
8,022 Views
14 Pages

Chikungunya Fever and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

  • José Kennedy Amaral,
  • Robert Taylor Schoen,
  • Michael E. Weinblatt and
  • Estelita Lima Cândido

Chikungunya fever (CHIKF) is a re-emerging infectious disease caused by the chikungunya virus (CHIKV), transmitted primarily by Aedes mosquitoes. A significant number progress to chronic chikungunya arthritis, which shares similarities with rheumatoi...

  • Case Report
  • Open Access
1,482 Views
11 Pages

A Case of Persistent KSHV Viremia in the Context of HIV, SARS-CoV-2, and Other Co-Infections

  • Humaira Lambarey,
  • Melissa J. Blumenthal,
  • Prishanta Chinna,
  • Vincent N. Naude,
  • Lauren Jennings,
  • Catherine Orrell and
  • Georgia Schäfer

Despite the high prevalence of latent Kaposi’s sarcoma-associated herpesvirus (KSHV) infections in patients from endemic areas with a high human immunodeficiency virus (HIV) prevalence, KSHV lytic reactivation in the context of other co-infecti...

  • Article
  • Open Access
1,899 Views
9 Pages

The HIV epidemic remains a major public health issue globally and in Vietnam. This study assesses changes in HIV/AIDS-related mortality rates over time in Lang Son Province, Vietnam, from 2005–2018. We performed a descriptive epidemiological st...

  • Article
  • Open Access
2 Citations
1,871 Views
15 Pages

Clinical Characteristics and a Novel Prediction Nomogram (EASTAR) for Patients with Hemorrhagic Fever with Renal Syndrome: A Multicenter Retrospective Study

  • Ke Ma,
  • Ting Wu,
  • Wei Guo,
  • Jun Wang,
  • Quan Ming,
  • Jun Zhu,
  • Hongwu Wang,
  • Guang Chen,
  • Xiaojing Wang and
  • Qin Ning
  • + 3 authors

Background: The fatality rate of hemorrhagic fever with renal syndrome (HFRS), due to hantavirus transmitted by rodents, ranges from 1% to 12%. This study aims to delineate the clinical and laboratory characteristics of HFRS, identify factors associa...

  • Article
  • Open Access
4 Citations
2,615 Views
24 Pages

Development and Characterization of Innovative Nifurtimox Formulations as Therapeutic Alternative for Chagas Disease

  • Ana Lia Mazzeti,
  • Karolina Ribeiro Gonçalves,
  • Patrícia Ferreira Boasquivis,
  • Maria Terezinha Bahia and
  • Vanessa Carla Furtado Mosqueira

Chagas disease, caused by Trypanosoma cruzi, remains a neglected tropical disease with limited and often suboptimal chemotherapeutic treatment options. The WHO recommends nifurtimox (NFX) for treating Chagas disease, which, although it is effective i...

  • Article
  • Open Access
1,397 Views
15 Pages

Large-Scale Deployment of Lehmann’s Funnel Entry Traps to Control Malaria Mosquito Populations

  • Hamidou Maïga,
  • Roger Sanou,
  • Bazoumana B. D. Sow,
  • Adama Ouema,
  • Abdoul Azize Millogo,
  • Koama Bayili,
  • Aristide Sawdetuo Hien,
  • Simon P. Sawadogo,
  • Souro Abel Millogo and
  • Abdoulaye Diabaté
  • + 3 authors

Effective tools to prevent mosquito bites are essential for malaria control. The Lehmann Funnel Entry Trap (LFET), a window screen proven effective in reducing mosquito density, was tested for its large-scale impact on malaria vector control and comm...

  • Article
  • Open Access
5 Citations
3,142 Views
10 Pages

Enhancing Healthcare Preparedness: Lessons from a Tabletop Exercise on Highly Pathogenic Avian Influenza (HPAI)

  • Priya Dhagat,
  • Joshua Coan,
  • Ayanava Ganguly,
  • Cole Puetz,
  • David Silvestri and
  • Syra Madad

Tabletop exercises offer a structured opportunity to assess strengths and potential gaps in preparedness and response plans in a safe learning environment. The New York City Health + Hospitals System-Wide Special Pathogens Program conducted an innova...

  • Article
  • Open Access
2 Citations
6,042 Views
19 Pages

Hand, Foot, and Mouth Disease (HFMD) predominantly affects children under the age of five and remains a significant public health concern in the Asia-Pacific region. HFMD outbreaks are closely linked to seasonal changes and meteorological factors, pa...

  • Article
  • Open Access
1 Citations
4,786 Views
16 Pages

Malaria in Nepal: A Spatiotemporal Study of the Disease Distribution and Challenges on the Path to Elimination

  • Kiran Raj Awasthi,
  • Jonine Jancey,
  • Archie C. A. Clements,
  • Kefyalew Addis Alene,
  • Suman Thapa,
  • Pramin Ghimire and
  • Justine E. Leavy

Malaria incidence (MI) has significantly declined in Nepal, and this study aimed to investigate the spatiotemporal distribution and drivers of MI at the ward level. Data for malaria cases were obtained from the National Surveillance System from 2013...

  • Review
  • Open Access
4 Citations
4,778 Views
25 Pages

HIV Cerebrospinal Fluid Escape: Interventions for the Management, Current Evidence and Future Perspectives

  • Sophie H. Kelly,
  • Sam Nightingale,
  • Ravindra K. Gupta and
  • Dami A. Collier

Neurocognitive impairment is an important cause of HIV-associated morbidity. The advent of antiretroviral therapy (ART) has shifted the spectrum of HIV-associated cognitive impairment from HIV-associated dementia to milder forms of cognitive impairme...

  • Article
  • Open Access
1 Citations
2,965 Views
27 Pages

“Time to Change”: To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis—A Qualitative Study Among End-Users

  • Vanessa Fargnoli,
  • Hoang Thi My Hanh,
  • Ly Na Hoang,
  • Ananya Mahesh,
  • Nasiphi Mqedlana-Ntombela,
  • Jovitta Xavier,
  • Mikashmi Kohli,
  • Kavindhran Velen and
  • Sonjelle Shilton

Inadequate access to timely diagnosis and linkage to treatment are major barriers to tuberculosis (TB) care. New point-of-care diagnostics that do not rely solely on sputum samples are needed to make up for lost time, bringing TB testing closer to se...

  • Article
  • Open Access
1 Citations
1,726 Views
13 Pages

Background: The vaccination programmes after the 2nd World War and the application of safe and effective vaccines were expected to eliminate infectious diseases within the World Health Organization (WHO) European Region. However, epidemiological inde...

  • Article
  • Open Access
8 Citations
5,472 Views
13 Pages

Schistosomiasis Burden and Trend Analysis in Africa: Insights from the Global Burden of Disease Study 2021

  • Dandan Peng,
  • Yajing Zhu,
  • Lu Liu,
  • Jianfeng Zhang,
  • Peng Huang,
  • Shaowen Bai,
  • Xinyao Wang and
  • Kun Yang

Schistosomiasis remains a major public health concern in Africa, despite global efforts to eliminate the disease by 2030. This study estimates the burden, trends, and inequalities of schistosomiasis in Africa from 1990 to 2021, and projects future pr...

  • Article
  • Open Access
3 Citations
2,828 Views
17 Pages

Malaria Mortality in Brazil: Age–Period–Cohort Effects, Sociodemographic Factors, and Sustainable Development Indicators

  • Mariusa Fernandes de Farias,
  • Eric Renato Lima Figueiredo,
  • Raimundo Nelson Souza da Silva,
  • Deizyane dos Reis Galhardo,
  • Cleide Laranjeira da Silva,
  • Evelyn Myelle Farias Moreira,
  • Yury Souza de Azevedo,
  • Emilly Cassia Soares Furtado,
  • Janielly Reis Castelhano and
  • Fabiana de Campos Gomes
  • + 1 author

Introduction: Human malaria is a zoonosis considered a serious global public health problem caused by five species of protozoa of the genus Plasmodium spp., which are transmitted by mosquito vectors belonging to the genus Anopheles spp. Objective: To...

  • Article
  • Open Access
2 Citations
3,946 Views
9 Pages

Utility of VIDAS® Dengue Diagnostic Assays to Differentiate Primary and Secondary Dengue Infection: A Cross-Sectional Study in a Military Hospital from Colombia

  • Andrés E. Prieto-Torres,
  • Leidy J. Medina-Lozano,
  • Juan David Ramírez-Ávila and
  • Álvaro A. Faccini-Martínez

This study aimed to assess the diagnostic utility of VIDAS® DENGUE NS1 Ag and anti-DENV IgM and IgG assays in parallel for an early and accurate diagnosis and classification of dengue virus (DENV) infection. For this retrospective cross-sectional...

  • Article
  • Open Access
4 Citations
4,621 Views
13 Pages

Intensive Therapeutic Plasma Exchange—New Approach to Treat and Rescue Patients with Severe Form of Yellow Fever

  • Yeh-Li Ho,
  • Youko Nukui,
  • Paula Ribeiro Villaça,
  • Erica Okazaki,
  • Nelson Hidekazu Tatsui,
  • Lucas Chaves Netto,
  • Daniel Joelsons,
  • Tania Rubia Flores da Rocha,
  • Fernanda de Mello Malta and
  • Vanderson Rocha
  • + 2 authors

Background: Severe yellow fever (YF) can result in acute liver failure (ALF) and high mortality. The role of therapeutic plasma exchange (TPE) in managing YF-ALF remains unclear. This study evaluated the impact of TPE strategies in severe YF. Methods...

  • Article
  • Open Access
6 Citations
5,266 Views
16 Pages

Background: Aedes species transmit arboviral diseases, such as dengue, chikungunya, yellow fever, and Zika. The diseases cause severe sickness, mortality, and economic losses. This study describes the biting hour and host-seeking behavior of Ae. aegy...

  • Case Report
  • Open Access
1 Citations
2,527 Views
11 Pages

Central Nervous System Infection by Free-Living Nematode Cephalobus cubaensis in a Human Host in Africa

  • Charlotte Sriruttan-Nel,
  • Chelline Cairns,
  • Shareen Boughan,
  • Bhavani Moodley,
  • Lisa Ming Sun,
  • Wai Yin Chan,
  • Arshad Ismail,
  • Absalom Mwazha,
  • Praniel Bennimahadeo and
  • Mahomed-Yunus Moosa
  • + 6 authors

Background: Human central nervous system infections due to free-living nematodes, although extremely rare, are usually fatal. Immunodeficiency has not been a feature of most of these cases, unlike the situation pertaining to disseminated Strongyloide...

  • Article
  • Open Access
1 Citations
3,963 Views
9 Pages

Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in all genders worldwide. Its association with male infertility is deeply investigated, although there are conflicting data on the role of the virus in the...

  • Brief Report
  • Open Access
1 Citations
2,419 Views
11 Pages

Wide Variation of Aedes albopictus Genotypes First Introduced into Canary Islands Assessed by rDNA Internal Transcribed Spacer Region and mtDNA cox1 Sequencing and Cloning

  • Alejandra De Elías-Escribano,
  • Irene Serafín-Pérez,
  • Patricio Artigas,
  • Carolina Fernández-Serafín,
  • Sara Rodríguez-Camacho,
  • Beatriz Yanes-Manrique,
  • Víctor González-Alonso,
  • Santiago Mas-Coma,
  • Jacob Lorenzo-Morales and
  • María Dolores Bargues

Aedes albopictus, one of the most rapidly spreading invasive mosquito species, has expanded from Asia to establish populations on every continent except Antarctica, showcasing exceptional adaptability, particularly in island environments. This study...

  • Article
  • Open Access
2,289 Views
12 Pages

Epidemiological Dynamics and Trends of Dengue Outbreaks in Sao Tome and Principe: A Comprehensive Retrospective Analysis (2022–2024)

  • Sousa Lazaro,
  • Vilfrido Santana Gil,
  • Ivando Carvalho Viegas de Ceita,
  • Isaulina Neto Viegas Barreto,
  • Eula Carvalho Batista Sousa Maquengo,
  • Andreza Batista de Sousa,
  • Bakissy da Costa Pina,
  • Tieble Traore,
  • Alimuddin Zumla and
  • John Otokoye Otshudiema

Background: Dengue has emerged as a significant public health concern in Sao Tome and Principe, with the first documented outbreak occurring between 2022 and 2024. This study examined the epidemiological patterns, environmental determinants, and demo...

  • Article
  • Open Access
1 Citations
1,709 Views
10 Pages

Viruses are a frequent cause of self-limited diarrhea, with more severe outcomes in immunocompromised patients. This study aimed to compare the performance of Real-Time RT-PCR to chromatographic immunoassays (CIAs) for detecting the major gastrointes...

  • Systematic Review
  • Open Access
1 Citations
3,589 Views
14 Pages

Molecular Detection of Mycobacterium leprae and the Process of Infection and Illness in Contacts of Leprosy Patients: A Systematic Review

  • Sarah Lamas Vidal,
  • Lavínia Cássia Ferreira Batista,
  • Daniele dos Santos Lages,
  • Bruna Eduarda Bortolomai,
  • Isabela de Caux Bueno,
  • Eyleen Nabyla Alvarenga Niitsuma,
  • Nathan Guilherme de Oliveira,
  • Ida Maria Foschiani Dias Baptista and
  • Francisco Carlos Félix Lana

Various techniques have been used for the molecular identification of Mycobacterium leprae (M. leprae). The aim of this review was to identify the relationship between the molecular presence of M. leprae and the process of infection and/or illness of...

  • Article
  • Open Access
2 Citations
1,794 Views
13 Pages

Transcriptome Analysis of Culex pipiens quinquefasciatus Larvae Exposed to a Semi-Lethal Dose of Vermistatin

  • Junhui Chen,
  • Zhiyong Xu,
  • Feiying Yang,
  • Jian Yang,
  • Wendong Kuang,
  • Jianghuai Li,
  • Yaqi Wang and
  • Liang Jin

Culex pipiens quinquefasciatus is a notorious vector transmitting severe diseases such as Zika virus and West Nile virus to humans worldwide. Vermistatin is a type of funicon-like compound and was first isolated from Penicillin vermiculatum in the 19...

  • Brief Report
  • Open Access
1 Citations
3,602 Views
11 Pages

A Retrospective Study of Clinical Biomarkers of Severe Dengue in a Tertiary Hospital in Johor Bahru, Malaysia

  • Si Yin Kok,
  • Ruth Elizabeth Abraham,
  • Shareen Nisha Jauhar Ali,
  • Wei Xuan Tuang and
  • Edmund Liang Chai Ong

Management of severe dengue remains a clinical challenge. This retrospective study evaluated clinical features and laboratory biomarkers associated with severe dengue at Hospital Sultanah Aminah Johor Bahru from 1 January 2022 to 31 March 2023. Recor...

  • Review
  • Open Access
9 Citations
28,089 Views
30 Pages

Schistosomiasis in the Philippines: A Comprehensive Review of Epidemiology and Current Control

  • Emmanuel John Tabilin,
  • Darren J. Gray,
  • Mario A. Jiz,
  • Mary Lorraine Mationg,
  • Marianette Inobaya,
  • Eleonor Avenido-Cervantes,
  • Megumi Sato,
  • Marcello Otake Sato,
  • Yasuhito Sako and
  • Catherine A. Gordon
  • + 4 authors

Schistosomiasis japonica is an infectious parasitic disease caused by infection with the blood fluke Schistosoma japonicum, which is endemic in China, small pockets of Indonesia, and the Philippines. Of the three countries, the prevalence of infectio...

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Trop. Med. Infect. Dis. - ISSN 2414-6366