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Non-Coding RNA, Volume 7, Issue 4

2021 December - 22 articles

Cover Story: Fifteen transcription factors (TF), such as IRF1, IRF2, MYC, RelA/p65, and STAT1, and 52 long non-coding RNAs (lncRNAs), such as BCDIN3D-AS1, MALAT1, NEAT1, and others, could coregulate 1066 protein-coding genes (PCG) altered in SARS-CoV-2 infected cells. Coregulated PCGs were enriched significantly with biological processes such as gene expression, mRNA splicing, the cell cycle, and the interleukin-1-mediated signaling pathway, and KEGG pathways such as ribosome, coronavirus disease, apoptosis, autophagy, MAPK signaling, the mTOR signaling pathway, and others relevant for COVID-19. Pathways related to other viral infections such as Hepatitis B, Hepatitis C, and Influenza A were also enriched significantly. Coregulation of PCG by lncRNA and TFs might play an important role in the pathogenesis of COVID-19. View this paper
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Articles (22)

  • Article
  • Open Access
7 Citations
3,921 Views
13 Pages

A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones

  • Wei Liu,
  • Yuyan Wang,
  • Hongchan Huang,
  • Nadege Fackche,
  • Kristen Rodgers,
  • Beverly Lee,
  • Wasay Nizam,
  • Hamza Khan,
  • Zhihao Lu and
  • Yuping Mei
  • + 12 authors

16 December 2021

The ability to differentiate between benign, suspicious, and malignant pulmonary nodules is imperative for definitive intervention in patients with early stage lung cancers. Here, we report that plasma protein functional effector sncRNAs (pfeRNAs) se...

  • Feature Paper
  • Review
  • Open Access
12 Citations
6,054 Views
18 Pages

15 December 2021

Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation. By contrast, the nature of these interactions and characteristics of the...

  • Review
  • Open Access
36 Citations
6,323 Views
38 Pages

13 December 2021

Milk is an integral and therefore complex structural element of mammalian nutrition. Therefore, it is simple to conclude that lactation, the process of producing milk, is as complex as the mammary gland, the organ responsible for this biochemical act...

  • Feature Paper
  • Review
  • Open Access
18 Citations
7,555 Views
23 Pages

13 December 2021

Over the last decade, tens of thousands of new long non-coding RNAs (lncRNAs) have been identified in the human genome. Nevertheless, except for a handful of genes, the genetic characteristics and functions of most of these lncRNAs remain elusive; th...

  • Review
  • Open Access
20 Citations
5,982 Views
25 Pages

Common Features in lncRNA Annotation and Classification: A Survey

  • Christopher Klapproth,
  • Rituparno Sen,
  • Peter F. Stadler,
  • Sven Findeiß and
  • Jörg Fallmann

13 December 2021

Long non-coding RNAs (lncRNAs) are widely recognized as important regulators of gene expression. Their molecular functions range from miRNA sponging to chromatin-associated mechanisms, leading to effects in disease progression and establishing them a...

  • Article
  • Open Access
7 Citations
3,630 Views
17 Pages

Trypsin Genes Are Regulated through the miRNA Bantam and Associated with Drug Sensitivity in the Sea Louse Caligus rogercresseyi

  • Gustavo Núñez-Acuña,
  • Valentina Valenzuela-Muñoz,
  • Crisleri Carrera-Naipil,
  • Constanza Sáez-Vera,
  • Bárbara P. Benavente,
  • Diego Valenzuela-Miranda and
  • Cristian Gallardo-Escárate

The role of trypsin genes in pharmacological sensitivity has been described in numerous arthropod species, including the sea louse Caligus rogercresseyi. This ectoparasite species is mainly controlled by xenobiotic drugs in Atlantic salmon farming. H...

  • Feature Paper
  • Review
  • Open Access
8 Citations
6,896 Views
40 Pages

Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs

  • Eva Slabáková,
  • Zuzana Kahounová,
  • Jiřina Procházková and
  • Karel Souček

Neuroendocrine prostate cancer (NEPC) represents a variant of prostate cancer that occurs in response to treatment resistance or, to a much lesser extent, de novo. Unravelling the molecular mechanisms behind transdifferentiation of cancer cells to ne...

  • Article
  • Open Access
6 Citations
5,631 Views
34 Pages

29 November 2021

Altered expression of protein coding gene (PCG) and long non-coding RNA (lncRNA) have been identified in SARS-CoV-2 infected cells and tissues from COVID-19 patients. The functional role and mechanism (s) of transcriptional regulation of deregulated...

  • Article
  • Open Access
5 Citations
4,778 Views
14 Pages

22 November 2021

Protein biosynthesis is essential for any organism, yet how this process is regulated is not fully understood at the molecular level. During evolution, ribosomal RNA expanded in specific regions, referred to as rRNA expansion segments (ES). First fun...

  • Concept Paper
  • Open Access
2 Citations
5,464 Views
15 Pages

10 November 2021

Currently there are nine known examples of transmissible cancers in nature. They have been observed in domestic dog, Tasmanian devil, and six bivalve species. These tumours can overcome host immune defences and spread to other members of the same spe...

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Non-Coding RNA - ISSN 2311-553X