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Non-Coding RNA, Volume 11, Issue 3

2025 June - 19 articles

Cover Story: CHROMR is a primate-specific long noncoding RNA with emerging roles in homeostasis and pathophysiology. Like many lncRNAs, CHROMR accumulates in both the nucleus and the cytoplasm, and it assumes distinct functions in each of these cellular compartments. In the nucleus, CHROMR sequesters a transcriptional repressor complex to activate interferon-stimulated gene expression and antiviral immunity. In the cytoplasm, CHROMR competitively inhibits microRNAs involved in cholesterol efflux and cell cycle regulation, thereby impacting gene pathways involved in reverse cholesterol transport, HDL biogenesis, and tumor growth. In this review, we detail the multifaceted functions of CHROMR in cholesterol metabolism, innate immunity, and cancer progression. View this paper
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Articles (19)

  • Brief Report
  • Open Access
1,216 Views
11 Pages

Insights into miRNAs of the Stingless Bee Melipona quadrifasciata

  • Dalliane Oliveira Soares,
  • Lucas Yago Melo Ferreira,
  • Gabriel Victor Pina Rodrigues,
  • João Pedro Nunes Santos,
  • Ícaro Santos Lopes,
  • Lucas Barbosa de Amorim Conceição,
  • Tatyana Chagas Moura,
  • Isaque João da Silva de Faria,
  • Roenick Proveti Olmo and
  • Eric Roberto Guimarães Rocha Aguiar
  • + 2 authors

MicroRNAs (miRNAs) are key post-transcriptional regulators involved in a wide range of biological processes in insects, yet little is known about their roles in stingless bees. Here, we present the first characterization of miRNAs in Melipona quadrif...

  • Article
  • Open Access
1 Citations
1,379 Views
23 Pages

Diagnostic Potential of Exosomal and Non-Exosomal Biomarkers in Lung Cancer: A Comparative Analysis Using a Rat Model of Lung Carcinogenesis

  • Sherien M. El-Daly,
  • Sahar S. Abdelrahman,
  • Amira Mohamed Abd El-Jawad,
  • Mahmoud A. Abdel-Monem and
  • Gamila S. M. El-Saeed

Background: Identifying liquid biopsy biomarkers with high efficacy is crucial for cancer diagnosis. Exosomal cargo, including miRNAs and proteins, offers enhanced stability in biofluids compared with their free circulating forms, but direct comparis...

  • Article
  • Open Access
879 Views
20 Pages

Patterns of Circulating piRNAs in the Context of a Single Bout of Exercise: Potential Biomarkers of Exercise-Induced Adaptation?

  • Caroline Eva Riedel,
  • Javier Ibáñez,
  • Annunziata Fragasso,
  • Angelika Schmitt,
  • Manuel Widmann,
  • Felipe Mattioni Maturana,
  • Andreas M. Niess and
  • Barbara Munz

Background: Physical activity induces a range of physiological and molecular adaptations, particularly affecting skeletal muscle and the cardiovascular system, regulating both tissue architecture and metabolic pathways. Emerging evidence suggests tha...

  • Article
  • Open Access
1,425 Views
15 Pages

Role of Compensatory miRNA Networks in Cognitive Recovery from Heart Failure

  • Verena Gisa,
  • Md Rezaul Islam,
  • Dawid Lbik,
  • Raoul Maximilian Hofmann,
  • Tonatiuh Pena,
  • Dennis Manfred Krüger,
  • Susanne Burkhardt,
  • Anna-Lena Schütz,
  • Farahnaz Sananbenesi and
  • Andre Fischer
  • + 1 author

Background: Heart failure (HF) is associated with an increased risk of cognitive impairment and hippocampal dysfunction, yet the underlying molecular mechanisms remain poorly understood. This study aims to investigate the role of microRNA (miRNA) net...

  • Review
  • Open Access
1,245 Views
17 Pages

CHROMR is a primate-specific long noncoding RNA with emerging roles in homeostasis and pathophysiology. Elevated blood levels of CHROMR have been observed in patients with cardiovascular disease and several cancers, where it is correlated with poor c...

  • Article
  • Open Access
1,385 Views
21 Pages

Human Papillomavirus-Encoded microRNAs as Regulators of Human Gene Expression in Anal Squamous Cell Carcinoma: A Meta-Transcriptomics Study

  • Daniel J. García,
  • Marco A. Pulpillo-Berrocal,
  • José L. Ruiz,
  • Eduardo Andrés-León and
  • Laura C. Terrón-Camero

Introduction: Anal squamous cell carcinoma (ASCC) is a rare but increasingly common gastrointestinal malignancy, mainly associated with oncogenic human papillomaviruses (HPVs). The role of non-coding RNAs (ncRNAs) in tumorigenesis is recognized, but...

  • Review
  • Open Access
1 Citations
1,540 Views
27 Pages

The poultry farming industry encounters considerable obstacles stemming from viral diseases, resulting in elevated mortality rates and substantial economic losses. Current research highlights the significant involvement of long non-coding RNAs (lncRN...

  • Article
  • Open Access
1,189 Views
25 Pages

Polychlorinated Biphenyl Exposure Alters tRNA Transcriptome in High-Fat Diet-Fed Mouse Liver

  • Carolyn M. Klinge,
  • Julia H. Chariker,
  • Kellianne M. Piell,
  • Belinda J. Petri,
  • Eric C. Rouchka and
  • Matthew C. Cave

Background/Objectives: Exposure of high-fat diet (HFD)-fed mice to polychlorinated biphenyls (PCBs) results in metabolic dysfunction-associated steatotic liver disease (MASLD) and progression to metabolic dysfunction-associated steatohepatitis (MASH)...

  • Correction
  • Open Access
572 Views
1 Page

Correction: Schlösser et al. Anti-HIV-1 Effect of the Fluoroquinolone Enoxacin and Modulation of Pro-Viral hsa-miR-132 Processing in CEM-SS Cells. Non-Coding RNA 2025, 11, 8

  • Verena Schlösser,
  • Helen Louise Lightfoot,
  • Christine Leemann,
  • Seyedeh Elnaz Banijamali,
  • Aathma Merin Bejoy,
  • Shashank Tiwari,
  • Jeffrey L. Schloßhauer,
  • Valentina Vongrad,
  • Andreas Brunschweiger and
  • Jochen Imig
  • + 2 authors

Seyedeh Elnaz Banijamali was not included as an author in the original publication [...]

  • Article
  • Open Access
1,539 Views
23 Pages

Analysis of RNA Transcribed by RNA Polymerase III from B2 SINEs in Mouse Cells

  • Olga R. Borodulina,
  • Sergey A. Kosushkin,
  • Ilia G. Ustyantsev,
  • Nikita S. Vassetzky and
  • Dmitri A. Kramerov

Background/Objectives: SINEs (short interspersed elements) are eukaryotic non-autonomous retrotransposons. They are transcribed by RNA polymerase III (pol III) and generate non-coding RNAs. The 3′ end of many mammalian SINEs contains a polyaden...

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Non-Coding RNA - ISSN 2311-553X