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Review

The Cohesin Complex and Its Interplay with Non-Coding RNAs

1
Junior Research Group ‘RNA Biology and Pathogenesis’, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany
2
Institute of Pathology, Section for Experimental Pathology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Nicholas Delihas
Non-Coding RNA 2021, 7(4), 67; https://doi.org/10.3390/ncrna7040067
Received: 29 September 2021 / Revised: 18 October 2021 / Accepted: 21 October 2021 / Published: 22 October 2021
(This article belongs to the Special Issue Non-coding RNA in Germany: Latest Advances and Perspectives)
The cohesin complex is a multi-subunit protein complex initially discovered for its role in sister chromatid cohesion. However, cohesin also has several other functions and plays important roles in transcriptional regulation, DNA double strand break repair, and chromosome architecture thereby influencing gene expression and development in organisms from yeast to man. While most of these functions rely on protein–protein interactions, post-translational protein, as well as DNA modifications, non-coding RNAs are emerging as additional players that facilitate and modulate the function or expression of cohesin and its individual components. This review provides a condensed overview about the architecture as well as the function of the cohesin complex and highlights its multifaceted interplay with both short and long non-coding RNAs. View Full-Text
Keywords: cancer; cohesion; miRNA; ncRNA; STAG1; STAG2; RAD21 cancer; cohesion; miRNA; ncRNA; STAG1; STAG2; RAD21
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MDPI and ACS Style

Kuru-Schors, M.; Haemmerle, M.; Gutschner, T. The Cohesin Complex and Its Interplay with Non-Coding RNAs. Non-Coding RNA 2021, 7, 67. https://doi.org/10.3390/ncrna7040067

AMA Style

Kuru-Schors M, Haemmerle M, Gutschner T. The Cohesin Complex and Its Interplay with Non-Coding RNAs. Non-Coding RNA. 2021; 7(4):67. https://doi.org/10.3390/ncrna7040067

Chicago/Turabian Style

Kuru-Schors, Merve, Monika Haemmerle, and Tony Gutschner. 2021. "The Cohesin Complex and Its Interplay with Non-Coding RNAs" Non-Coding RNA 7, no. 4: 67. https://doi.org/10.3390/ncrna7040067

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