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Concept Paper

Between the Devil and the Deep Blue Sea: Non-Coding RNAs Associated with Transmissible Cancers in Tasmanian Devil, Domestic Dog and Bivalves

School of Biotechnology and Biomedical Sciences, Faculty of Science, UNSW Sydney, Sydney, NSW 2052, Australia
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Author to whom correspondence should be addressed.
Academic Editors: Pier Paolo Pandolfi and Laura Poliseno
Non-Coding RNA 2021, 7(4), 72; https://doi.org/10.3390/ncrna7040072
Received: 6 October 2021 / Revised: 5 November 2021 / Accepted: 9 November 2021 / Published: 10 November 2021
Currently there are nine known examples of transmissible cancers in nature. They have been observed in domestic dog, Tasmanian devil, and six bivalve species. These tumours can overcome host immune defences and spread to other members of the same species. Non-coding RNAs (ncRNAs) are known to play roles in tumorigenesis and immune system evasion. Despite their potential importance in transmissible cancers, there have been no studies on ncRNA function in this context to date. Here, we present possible applications of the CRISPR/Cas system to study the RNA biology of transmissible cancers. Specifically, we explore how ncRNAs may play a role in the immortality and immune evasion ability of these tumours. View Full-Text
Keywords: transmissible; CRISPR/Cas; cancer; ncRNAs; Tasmanian devil; bivalve; domestic dog transmissible; CRISPR/Cas; cancer; ncRNAs; Tasmanian devil; bivalve; domestic dog
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MDPI and ACS Style

Lister, N.C.; Milton, A.M.; Hanrahan, B.J.; Waters, P.D. Between the Devil and the Deep Blue Sea: Non-Coding RNAs Associated with Transmissible Cancers in Tasmanian Devil, Domestic Dog and Bivalves. Non-Coding RNA 2021, 7, 72. https://doi.org/10.3390/ncrna7040072

AMA Style

Lister NC, Milton AM, Hanrahan BJ, Waters PD. Between the Devil and the Deep Blue Sea: Non-Coding RNAs Associated with Transmissible Cancers in Tasmanian Devil, Domestic Dog and Bivalves. Non-Coding RNA. 2021; 7(4):72. https://doi.org/10.3390/ncrna7040072

Chicago/Turabian Style

Lister, Nicholas C., Ashley M. Milton, Benjamin J. Hanrahan, and Paul D. Waters. 2021. "Between the Devil and the Deep Blue Sea: Non-Coding RNAs Associated with Transmissible Cancers in Tasmanian Devil, Domestic Dog and Bivalves" Non-Coding RNA 7, no. 4: 72. https://doi.org/10.3390/ncrna7040072

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