Dear Colleagues,

Process modelling for the purpose of monitoring, prediction and control of bioengineering systems, such as the activated sludge process, anaerobic digestion, and biopharmaceutical manufacturing, is well-established. Nevertheless, bioengineering technology and methods to understand and manipulate their underlying processes are still developing in response to challenges such as climate change, resource security and urbanization. Biological processes and bioengineering are at the vanguard of transformative change through the nexus of academic, industry, policy and good governance. As an example, water resource recovery inspires a broader approach to the design, management and operation of ‘waste’ water treatment and the added dimensionality of end-product value and quantity suggests the need for new models, measurements and control strategies.

A new frontier in modelling for bioengineering is being established at the intersection between complementary fields such as data analytics, machine learning, smart sensors, genomics, metabolic engineering and soft computing. The era of distinct disciplines working largely in silos has passed and the future of bioprocesses is truly innovative and multidisciplinary.

With the closer integration of science and engineering and an emphasis on practical solutions to tackle urgent environmental, energy, and public health challenges across scales, this Special Issue invites contributions that place bioprocess modelling, monitoring and control in the domain of transformative bioengineering. The scope covers biotechnologies, processes or sub-processes and across scales, but must be framed in one or more of the core topic areas (modelling, monitoring and control), and should ideally address current or anticipated societal challenges (e.g., Sustainable Development Goals), future-facing systems (e.g., water resource recovery facilities, fully continuous bio-manufacturing) or a major technical bottleneck related to bioprocessing.

Dr. Matthew Wade
Dr. Dongda Zhang
Dr. Sovanna Tik 
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Biological process modelling
• Biological process control
• Biological process monitoring
• Process optimization
• Advanced process control
• Predictive modelling and control
• Hybrid modelling
• Plant-wide modelling
• Process analytical technology and quality by design
• Water resource recovery processes
• Fermentation processes
• Pharmaceutical bioprocesses
• Metabolic engineering for bioprocesses