You are currently viewing a new version of our website. To view the old version click .

Bioengineering, Volume 12, Issue 2

February 2025 - 116 articles

Cover Story: Critical-sized bone defects, which can result from trauma, infection, or tumor removal, present major challenges for orthopedic surgeons. Current treatments like bone grafts have significant limitations such as donor site complications and variable outcomes. Regional gene therapy has emerged as a promising solution that combines genetic engineering with tissue engineering principles. This approach involves either directly delivering therapeutic genes to the defect site or implanting genetically modified stem cells that produce bone-forming proteins. Such stem cells can be obtained from various sources including bone marrow, fat, or muscle tissue. This strategy aims to provide all the essential components for bone repair while minimizing the complications associated with the current treatments. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (116)

  • Review
  • Open Access
2 Citations
5,248 Views
18 Pages

The Role of Magnesium, Zinc, and Strontium in Osteoporotic Fracture Repair

  • Zhen Wang,
  • Penghui Xiang,
  • Zhe Xu,
  • Meiqi Gu,
  • Rui Zhang,
  • Yifei Li,
  • Hua Chen,
  • Li He and
  • Chengla Yi

Osteoporotic fractures represent a significant public health challenge in the context of an aging global population, with the rising prevalence of osteoporosis intensifying the demand for effective fracture treatment. Restoring the structure and func...

  • Review
  • Open Access
3 Citations
4,222 Views
20 Pages

Scaffold-Free Strategies in Dental Pulp/Dentine Tissue Engineering: Current Status and Implications for Regenerative Biological Processes

  • Mohammad Samiei,
  • Martin Conrad Harmsen,
  • Elaheh Dalir Abdolahinia,
  • Jaleh Barar and
  • Xenos Petridis

Conventionally, root canal treatment is performed when the dental pulp is severely damaged or lost due to dental trauma or bacterial endodontic infections. This treatment involves removing the compromised or infected pulp tissue, disinfecting the roo...

  • Article
  • Open Access
1 Citations
1,514 Views
12 Pages

Utilizing Integrated Bioinformatics Analysis to Explore Potential Alterations in Mitochondrial Function Within Immune Cells Associated with Thoracic Aortic Aneurysms

  • Chang Guan,
  • Si-Xu Chen,
  • Chun-Ling Huang,
  • Yi-Peng Du,
  • Kai-Hao Wang,
  • Pei-Xin Li,
  • Shen-Rong Liu,
  • Zhao-Yu Liu and
  • Zheng Huang

Thoracic aortic aneurysm (TAA) is a life-threatening peripheral vascular disease with a complex pathogenesis. Altered mitochondrial function in vascular smooth muscle cells has been implicated in TAA development. However, the link between mitochondri...

  • Article
  • Open Access
1 Citations
1,602 Views
20 Pages

Computer-aided detection (CADe) of masses in digital breast tomosynthesis (DBT) is crucial for early breast cancer diagnosis. However, the variability in the size and morphology of breast masses and their resemblance to surrounding tissues present si...

  • Article
  • Open Access
2 Citations
3,470 Views
24 Pages

A Non-Invasive Approach for Facial Action Unit Extraction and Its Application in Pain Detection

  • Mondher Bouazizi,
  • Kevin Feghoul,
  • Shengze Wang,
  • Yue Yin and
  • Tomoaki Ohtsuki

A significant challenge that hinders advancements in medical research is the sensitive and confidential nature of patient data in available datasets. In particular, sharing patients’ facial images poses considerable privacy risks, especially wi...

  • Article
  • Open Access
1,608 Views
23 Pages

Energy Saving in Permanent Cardiac Pacing: Pulse Waveform and Charge Balancing Deserve Consideration

  • Franco Di Gregorio,
  • Lina Marcantoni,
  • Aldo Mozzi,
  • Alberto Barbetta and
  • Francesco Zanon

The pacing pulse produced by implantable stimulators can be described as a truncated exponential decay from the starting peak amplitude, corresponding to the discharge of the output stage capacitance (reservoir and isolation capacitors, in series) al...

  • Article
  • Open Access
1,684 Views
18 Pages

Bayesian Hierarchical Modeling for Variance Estimation in Biopharmaceutical Processes

  • Sonja Schach,
  • Tobias Eilert,
  • Beate Presser and
  • Marco Kunzelmann

Determining process variances in biopharmaceutical manufacturing is challenging due to limited data availability. To address this, we introduce a Bayesian hierarchical model designed for meta-analysis of process variance. This approach can improve pr...

  • Brief Report
  • Open Access
1 Citations
1,281 Views
12 Pages

Organisms maintain circadian rhythms corresponding to approximately 24 h in the absence of external environmental cues, and they synchronize the phases of their autonomous circadian clocks to light–dark cycles, feeding timing, and other factors...

  • Article
  • Open Access
3 Citations
1,226 Views
14 Pages

Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study

  • Siting Li,
  • Shiyi Yang,
  • Xiaoning Sun,
  • Tianxiang Ma,
  • Yuehong Zheng and
  • Xiao Liu

Intraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) is associated with disease progression and complications. This study investigates the relationship between nitric oxide (NO) concentration and ILT in AAA patients using patient-specif...

of 12

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Bioengineering - ISSN 2306-5354